ID A0A0M2GTE7_9ACTN Unreviewed; 3642 AA.
AC A0A0M2GTE7;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Peptide synthetase {ECO:0000313|EMBL:KJK39401.1};
GN ORFNames=UK15_13125 {ECO:0000313|EMBL:KJK39401.1};
OS Streptomyces variegatus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=284040 {ECO:0000313|EMBL:KJK39401.1, ECO:0000313|Proteomes:UP000034786};
RN [1] {ECO:0000313|Proteomes:UP000034786}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-16380 {ECO:0000313|Proteomes:UP000034786};
RA Ju K.-S., Doroghazi J.R., Metcalf W.;
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJK39401.1}.
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DR EMBL; JYJH01000007; KJK39401.1; -; Genomic_DNA.
DR RefSeq; WP_031135343.1; NZ_JYJH01000007.1.
DR STRING; 284040.UK15_13125; -.
DR PATRIC; fig|284040.3.peg.7317; -.
DR Proteomes; UP000034786; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 4.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 4.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 8.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 645..719
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2147..2221
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3569..3642
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2218..2237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3642 AA; 392114 MW; 517AD3C04A4AB4DC CRC64;
MMQPRARLAP LSPTRLADVR RRIGDYPDGT ITEACAIALS YWATGRSPEG IDLTPGTLFA
DVLGWVDNGG SAPGGWEVTP DGHGITVPDG VTPEDAQLAL DDLADFPDRP LGTVGPSSVA
ARLRTLAGWN DNRADRVRPT IVEMFHEQAR TRPDAVAVVD EHRTLTYREA AEHAGQLAHH
LLARGLGSEQ VVGISLTRSA DMVIGLLAVL QAGCAFVPLD PQWPAARRIV VIEDARVVVQ
LNASGEHDPA EPDAVAVDLG DWQYGSYPAE GPGVTVLGDA LAYVIFTSGS TGRPKGAMIR
HEAISERLLW QVNEILGFGH DDASLFKAPL SFDISINEIF LPLVSGGRLV VLRPGGERDP
HHLLSVIAEQ RVTFTYLVSS MLDVLLEMAG DTGRLDSLRH VWCGGEVLTP ELYERFRTRL
DNVPMYHGYG PAETTIGVSH VIYRGAAERL STSIGKANPN TQLYVLDEEL RPVPVGVGGE
LYVGGFLLGR GYVGAPGLTA SRFVANPFAD DGSRLYRTGD LARFAPDGSL DFLGRADNQI
KIRGMRLEIE DVEAGLAEHP RVRHTCVVAK KNTAGGTYLV GYVIPATGGE DLRADEVKAW
AAEHMVEYMV PAHLVVMEEF PLTANGKLDR NALPEPTIET GSLVRPTTDD ERAVCAAVAQ
VLRLDEVGVD QDFFQLGGDS ILAISLLSAL RDEGLHVTAR QIFTHSTVGA LAAVASREDV
STADHGDVAT GTVVGSPIVQ WLGETTDAVD GFVQSVVLNT PADLTADALD EILSALVRHH
DMLRAKLVRG DDWSFDIPEA DGAFVTWQES DLPVEECVAL ATEGLDPDAG SMLRAVWRRE
ARQLVLVAHH VVIDGVSWRV LMEDLATAWR QSTSGMPIEL PPVGTSFRRW TQLLERAAFD
ADSAYYRRPL PGEDHPLGRR ALSAADTVAH ERLRTVSVGP EITAALLGEI PAKFHAGVND
VLLTALAVAL ARRRRDLGQD QTFAHIELEG HGREGQFVAG SAGFDPELSR TVGWFTTLFP
VTVDPGTAAD LTTPAYLTAA LKAVKEDLAR VPDNGISYGA LRYLTHSEFD APAPQVLLNY
LGRFAAGAPG DWQLAGTTGQ LGEKRDPRMR LPRALEFNAI AEPAASGAYE LVTTISWPDG
MFTDADITTL GDYFRTALAG LAALGEGGHS PSDFPLVPLT QTDVDALDGP ALRDILPLTP
LQEGLYFHSV FDDDSAGAYV EQQLLTLDGE VDADRLAAAA TRLLTLFPNL AARFTALADG
RVVSVLESGV QAPFTTLDRP GITDEEIRAL TERDRRAGFD LANGPLMRYT LIRTGSGRNV
LVQTVHHIIA DGWSVPPMLR ALLAEYHAPG TVYPIGGFAD YVHWLARRDD DESDRVWSAE
LAGLPGPSLV AEDHTPSDRF ADTAAEPEGD LDAAVREAGV PLSVAVHSAW AVTLGGILHG
SDVVFGSTVS GRDAEVPGIG DMVGLFINTI PVRARWADGT TSSDLLASVR EHQSAVLPHQ
HVSLARIGRQ AGAGSLFDTL VVFDVATDVA ALRRPDDTLV VSDLVNEGAP HYPLTLVVER
ALDGRPRFNL IYDGELLRET TAQSILHTFT HTLTGLLTRP DALVDDLAPE SERRPAPITP
TTLGGLFDAA ARRDPAATAV TQCGLDGGTR SLTYGELADT KNELASALRA AGVGLGKRVA
VAVPRSLEQV VALVAIVSAG GAYVPLDLAY PDDRLEYILA DAAPQVVLVD REQRDRFTEL
LARAGVPARV LVQGDELPAG DTTEPEVSWH NPAYVIYTSG STGRPKGVAV PHSGVVSLLA
NTQPDMDFGP QDVWVQFHSF SFDFAVWELW GALAYGGELL VPEYGLTRSP VDFHRLVREH
GVTVLNQTPS AFYQFIEADR LAGEPLPALR RIIFGGEALD LGRLRGWVER HGTGAPELVN
MYGITETTVH VTRRVLTDED FGPGDDASPI GGPIPGLVTY LLDDRLRPVP PGKVGAIYVA
GDQVSLGYLG RPGLTAGRFV ANPFADDGSR MYHTGDLAIR TLDGELQFTG RADDQVQLKG
FRIELGEVES AVRELDGVVD VAVTVADSGD HLVAHVVGQA PGDFAELLST KLPVHMVPGR
LLTIDALPLT VNGKLDRKTL TERTFGGAGL YPYAAPPRGA TSPNAPADKN SAVTALIEIF
TQTLPGTAVD ADTDFFHAGG DSIVAITVVN RARTLGLQIS PREVFLLKTP RALADNLATS
TPQTAAPAPA RREDGPLTPT PIILRQRELG GSLTRFAQAR TLQAPEGTAF TDAQRAANAV
VAAHPTLRLR LRIEHGVWAL RTEPAHEVTV VRPDTTDATA VANEAAAQLD PESGNVIAFA
WLEATRTLVV TVHHLAVDSV SWLILLDDLA AALRGETLAP PTTSYAEYAE ALKLHSTHAL
DDLGHWTTTL QAPELLPTVG GLRETTVVLA PDVSDRLTRT APAALGVGLT ELLCGALRTA
LTRVQPSPTD LAIELERHGR VPVLEQHDYT RTVGWFTSIA PVRLTPHTDP VAAAREVAER
QPDERAHVAY GQLRYLDPQT APLLTARPQV LFNYLGRGSE SQALHLTGGD QGSPYAVEVN
AWTDEATGSL LAEFTLAEGI PDEITEHWRG ALEHIADAAT TAERTAPVTP LQRGLFFQAQ
MAGTAGHYVA QSWFTFDRRL DTDALAEAMT YVIARHPVVG AGFSTDDDGN PVQVLKAGRR
VDVRTVALST DSEVDALRAR DRDTGFDPGE PPLIRLTVVR LPDDRDGLLL SYHLLLWDGW
SREIVLRDLF DAYRAVLAGE PLDPMPATPS FEEYARALDA KDPAVSERFW AEHLAGLPGP
TLLAGPAPAL SDDLPRALVH TLSAEQSELL RDAARVHGVT LNSVLTGAFG LLLGAHTGRS
DAVFGVTVSG RDGEGLDGIV GVLLNTVPTW TRARPDESVR EYLSAVQTAR VEAMEHEHLG
LGEIQRASGH DTLFDNLFVL QNFLDMDAFA EMNARHGITS VKADDSTHYP FTWVVTPGDR
LTVKLEYRDG DTAGARRLLD DFLSVLQDLA RSTGPVGALR GLGPVPEPAA RTDVGTDTVV
DRFDRAADRD PQRVALVADG STMTFGELRD RSRAVAGVLA GRGIGPETTV GLAIPRSLDW
IVALFAVLRV GAAYVPLELD HPDERIAAIV EDAGPDLILT VSTVSPRLAG ELIELDRPLP
ETGPFVTFAP DDPDRLRHPA YTIYTSGSTG KPKGVVTEYA GLTNMLINHQ RRIFEPVLAE
HGHRIFRIAH TVSFAFDMSW EELLWLADGH EVHICDEELR RDAPRLVEYC LEHGIDVVNV
TPTYAQQLVA EGLLDNPARR PALVLLGGEA VTPTLWQRLS DTEGTVGYNL YGPTEYTINT
LGVGTFECED PVVGVAIDNT DVYVLDPWLR PLPDGVPGEL YVSGIGIARG YLGQPAQTAH
RFVACPFGEP GERMYRTGDL VVRRPDGNLM YLGRTDQQVK IRGHRVELGE VEAVFAAHPA
VRFAAAVAQP DPQVDGAYRL AAYLVLEDAQ LAAVAAEVGA GLPDFLRPTH YAQVDSIPLT
VNGKADTKAL PEAKPLGALT TVGERGPETE TETVVCEYFA EALDLDDDEV SAVSDFVSLG
GHSMLAVRLV GLLRREYGPV ITIRDLFTLR TPEAIARHLD DN
//