ID A0A0M2HHR7_9MICO Unreviewed; 991 AA.
AC A0A0M2HHR7;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Glutamate-ammonia-ligase adenylyltransferase {ECO:0000313|EMBL:KJL46250.1};
DE EC=2.7.7.42 {ECO:0000313|EMBL:KJL46250.1};
GN Name=glnE {ECO:0000313|EMBL:KJL46250.1};
GN ORFNames=RS84_02877 {ECO:0000313|EMBL:KJL46250.1};
OS Microbacterium hydrocarbonoxydans.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microbacterium.
OX NCBI_TaxID=273678 {ECO:0000313|EMBL:KJL46250.1, ECO:0000313|Proteomes:UP000033900};
RN [1] {ECO:0000313|EMBL:KJL46250.1, ECO:0000313|Proteomes:UP000033900}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SA35 {ECO:0000313|EMBL:KJL46250.1,
RC ECO:0000313|Proteomes:UP000033900};
RA Corretto E.;
RT "Draft genome sequences of ten Microbacterium spp. with emphasis on heavy
RT metal contaminated environments.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJL46250.1}.
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DR EMBL; JYJB01000010; KJL46250.1; -; Genomic_DNA.
DR RefSeq; WP_045258459.1; NZ_JYJB01000010.1.
DR AlphaFoldDB; A0A0M2HHR7; -.
DR STRING; 273678.RS84_02877; -.
DR PATRIC; fig|273678.4.peg.2879; -.
DR OrthoDB; 9759366at2; -.
DR Proteomes; UP000033900; Unassembled WGS sequence.
DR GO; GO:0008882; F:[glutamate-ammonia-ligase] adenylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR CDD; cd05401; NT_GlnE_GlnD_like; 2.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 2.
DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 2.
DR InterPro; IPR023057; GlnE.
DR InterPro; IPR005190; GlnE_rpt_dom.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR013546; PII_UdlTrfase/GS_AdlTrfase.
DR PANTHER; PTHR30621:SF0; BIFUNCTIONAL GLUTAMINE SYNTHETASE ADENYLYLTRANSFERASE_ADENYLYL-REMOVING ENZYME; 1.
DR PANTHER; PTHR30621; GLUTAMINE SYNTHETASE ADENYLYLTRANSFERASE; 1.
DR Pfam; PF08335; GlnD_UR_UTase; 2.
DR Pfam; PF03710; GlnE; 2.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 2.
DR SUPFAM; SSF81593; Nucleotidyltransferase substrate binding subunit/domain; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000313|EMBL:KJL46250.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:KJL46250.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000033900};
KW Transferase {ECO:0000313|EMBL:KJL46250.1}.
FT DOMAIN 83..326
FT /note="Glutamate-ammonia ligase adenylyltransferase
FT repeated"
FT /evidence="ECO:0000259|Pfam:PF03710"
FT DOMAIN 353..488
FT /note="PII-uridylyltransferase/Glutamine-synthetase
FT adenylyltransferase"
FT /evidence="ECO:0000259|Pfam:PF08335"
FT DOMAIN 594..825
FT /note="Glutamate-ammonia ligase adenylyltransferase
FT repeated"
FT /evidence="ECO:0000259|Pfam:PF03710"
FT DOMAIN 863..989
FT /note="PII-uridylyltransferase/Glutamine-synthetase
FT adenylyltransferase"
FT /evidence="ECO:0000259|Pfam:PF08335"
SQ SEQUENCE 991 AA; 108311 MW; 7838DC15F23C7ADE CRC64;
MARSDEPGSL SALARLGFAG LSEAAGSLDE LAGLLGLDRA ALLDGAQAAD PDAAVEGMLR
VARRDAGPLK ELFLDADSRL RAWRVFGSSP GLAGFFLRHP SELSVLSAQR DRLPTAIELR
ARLLEAVGVV DGFAATAGDS ALVALRVAYR RELAGIAAFD VSHERPVDVV GDVAAALADI
AGAALEASLA VARTQVRSAF PGEEIAATQL AVIGMGKAGA RELNYVSDVD VIFVGGTSDE
DAVSEARAID IATRLARETM RGLSGIEAEP PLWEVDAALR PEGKQGALVR SLASHLAYYD
RWAKSWEFQA LLKARPLAGD AALGAAYIEA VQPKVWSSAA RENFVDSVQR MRERVMEHID
PEDAPYQLKL GAGGLRDIEF TVQLLQLVHG LTDPTIRTRG TLESIDALVE GGYIGRAEAA
TFADDYRVLR LMEHRLQLRE LSRTHLMPRT PAGLRVLARS TGLAESGEAI WQRWESVRRE
VREIHIRLFY RPLLSAVASL PEDERTLSTA QAHDRLAAIG FRDPTGALRH IGALTTGLSR
KATIQRHLMP VMVRWFADGS DPDYALIAFR RISERLGDTP WFLRMLRDSS GAAESLTRLL
SSSRYIGELM EWIPESVAWL DSTELLRPRS RAAIDEEARA IQTRHDSVQG ALRAVRALRR
RELLRTAMGA VLDVLTIEEV ATSLTEITDA TIQAALRAVY REVVPPEDSA LDFAVIGMGR
FGGAELGFGS DADILFVYDA NGVDPERARK LSMLIVNGLR EHLSDNRVPL DLDADLRPEG
RNGPVVRSIE AYAEYYRRWS LSWEAQALLR ARGVAGSAKL TSRFMALADS IRYPAAIDLQ
GTREIKRIKA RVEGERLPQG ADPRRHLKLG PGTLSDVEWL VQLLQLQHAH DVPALRTTST
MAALDAAVEA ELVPAASADL LREAWRLSSR LRSAITLFTG QTSDVLPTEP RQLDAIGILL
GYPERSATVL EDDYLGVTRR ARKAFETLFY G
//
