ID A0A0M2HUV8_9MICO Unreviewed; 994 AA.
AC A0A0M2HUV8;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Na(+)/H(+) antiporter subunit A {ECO:0000313|EMBL:KJL48228.1};
GN Name=mrpA {ECO:0000313|EMBL:KJL48228.1};
GN ORFNames=RS84_01860 {ECO:0000313|EMBL:KJL48228.1};
OS Microbacterium hydrocarbonoxydans.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microbacterium.
OX NCBI_TaxID=273678 {ECO:0000313|EMBL:KJL48228.1, ECO:0000313|Proteomes:UP000033900};
RN [1] {ECO:0000313|EMBL:KJL48228.1, ECO:0000313|Proteomes:UP000033900}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SA35 {ECO:0000313|EMBL:KJL48228.1,
RC ECO:0000313|Proteomes:UP000033900};
RA Corretto E.;
RT "Draft genome sequences of ten Microbacterium spp. with emphasis on heavy
RT metal contaminated environments.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000320}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJL48228.1}.
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DR EMBL; JYJB01000008; KJL48228.1; -; Genomic_DNA.
DR RefSeq; WP_045257452.1; NZ_JYJB01000008.1.
DR AlphaFoldDB; A0A0M2HUV8; -.
DR STRING; 273678.RS84_01860; -.
DR PATRIC; fig|273678.4.peg.1863; -.
DR OrthoDB; 9811798at2; -.
DR Proteomes; UP000033900; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR007182; MnhB.
DR InterPro; IPR025383; MrpA_C/MbhD.
DR InterPro; IPR046806; MrpA_C/MbhE.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR43373:SF1; ANTIPORTER SUBUNIT MNHA2-RELATED; 1.
DR PANTHER; PTHR43373; NA(+)/H(+) ANTIPORTER SUBUNIT; 1.
DR Pfam; PF13244; MbhD; 1.
DR Pfam; PF20501; MbhE; 1.
DR Pfam; PF04039; MnhB; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000033900};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000320};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 75..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 513..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 574..594
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 606..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 632..651
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 657..676
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..714
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 756..773
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 833..854
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 860..877
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 898..918
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 938..960
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..102
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 127..398
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
FT DOMAIN 617..680
FT /note="MrpA C-terminal/MbhD"
FT /evidence="ECO:0000259|Pfam:PF13244"
FT DOMAIN 696..770
FT /note="MrpA C-terminal/MbhE"
FT /evidence="ECO:0000259|Pfam:PF20501"
FT DOMAIN 835..956
FT /note="Na+/H+ antiporter MnhB subunit-related protein"
FT /evidence="ECO:0000259|Pfam:PF04039"
SQ SEQUENCE 994 AA; 104695 MW; 07DA6ADD742AC6F6 CRC64;
MLTLLGAFLL SSVVMPVLVR WMGARAFFIA ALIPAGAFVH ALMLTPQVLH AASAPYESVE
WIPQLGLNMS MHMDVLGWVL TLIVTGVGAL VLLYCRWYFH DDSVGLGQFA AVLLGFAGAM
YGLVLTDDLV MLVMFWEVTS ILSYLLIGYY RRRAASRRAA LQALLVTTLG GLVMFVGVVL
LVVDAGTSSI REILALAPTG PIVDAAIVML LVGAISKSAL FPFHFWLPGA MAAPTPVSAY
LHAAAMVKAG IYLIARFAPI FAFSGPWRPI LISLGVFTML LGGVQALRET DLKRILAFGT
VSQLGFFSVV IGYGTQAAAL AGLALVIAHA LFKSALFLIV GVIDRQLSTR DVTELSGVGR
QAPVLAVTAF ISVASMAGIA PTIGFVAKES ALTALLDDAQ GGSVWGLVAL IGIVLGSMLT
AAYGARFLWG AFFSKRDAQG ERMPDTAWPG PPLGFVAAPI VLAALTLAAG IGAPALDAAL
QGYAVTATPG LDHAGEAAEG PGHLALWHGL EPALGISIVS ILLGIGVFLL TRRTGWERRP
RVLPFTAADA YYAVVRAIDR LSVLSTTLTQ RGSLPVYVGT IFVVFVAAEA TALLASDIDR
IQLSAWHTPA QIAAAPLMAV AGIFAVRAQK RYTGVVLVSV TGLGMVALFA TSGAPDLALT
QILVETVTMV TFALVLRRLP SRMGEHNASV GRIPRALLGI GVGVTMALVA IVATQSRVAE
PISTLFPKLA YELGHGKNVV NVALVDLRGW DTMGELSVLV LAATGVASLV FVTHRADLLA
ATKTLPKATR RATRSRPLVE TTDGIRFQTS ENRSSPRAWL VGGTNMKPEN RSILLEVIVR
ILFHTIIVVS IFLLFSGHNL PGGGFAGGLV AGMALVMRYI AGGRWELGAA APTDAGRLLG
TGLVLAVGSA VVPLFFGLAP LTSRFWEWEL PGFGHMEFVT STIFDIGVYL VVIGLVLDVL
RSLGAEVDRQ AAALRSAQDA STPSGTDRPR GVSI
//
