ID A0A0M2JPZ6_9MYCO Unreviewed; 2566 AA.
AC A0A0M2JPZ6;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:KKE98595.1};
DE Flags: Fragment;
GN ORFNames=WN67_28415 {ECO:0000313|EMBL:KKE98595.1};
OS Mycolicibacterium obuense.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1807 {ECO:0000313|EMBL:KKE98595.1, ECO:0000313|Proteomes:UP000034150};
RN [1] {ECO:0000313|EMBL:KKE98595.1, ECO:0000313|Proteomes:UP000034150}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UC1 {ECO:0000313|EMBL:KKE98595.1,
RC ECO:0000313|Proteomes:UP000034150};
RA Greninger A.L., Cunningham G., Chiu C.Y., Miller S.;
RT "Genome sequence of Mycobacterium obuense UC1.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKE98595.1}.
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DR EMBL; LAUZ02000065; KKE98595.1; -; Genomic_DNA.
DR STRING; 1807.MOBUDSM44075_02637; -.
DR PATRIC; fig|1807.13.peg.4536; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000034150; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd08956; KR_3_FAS_SDR_x; 2.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 4.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 2.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM01294; PKS_PP_betabranch; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 5.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 410..485
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 504..929
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2416..2491
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KKE98595.1"
SQ SEQUENCE 2566 AA; 266622 MW; 62CEEFE6D204B3B2 CRC64;
FLAATGGRGV DVVLDSLAGD FVDASLRLLP RGGVFLEMGK TDIRDADAVA AAHPGVTYRA
FDLFEPGRPR MAEYLVELSA LFDAGVLQPL PVTTFDIRRA LAALRYLSQA RQIGKVVMTM
PDTWTAGTVL ITGGTGMAGA TVARHVVAHH GVRDLLLVSR RGPAAPGADG LVADLQAVGA
RVRVVAADVA DREQLAGLLA GVDGPLTAVI HAGGVLDDAV IGSLTPERVD TVLRAKVDAA
WNLHELTLGS DVAAFVLFSS LAGVVGSPGQ GNYAAGNTFL DGLAAHRRAA GLPAISLAWG
LWDQASDMTG HLETAALERL GRDGVLALSA ADAMELFDAA LTVEEALLAP ARLDRAALRA
RSAQGLLPPM FAELVSVRSR RRVDDSVAAA TSQSALAKRL TGKSEAEQQA LVLDVLRSHM
ATVLGTTEPE RIDGALAFAE HGFDSLTAVE LRNRLKAATG LALSPTLIFD YPTPDALAGY
IRTELAGAAP AAPVEAPTAR SVIDEPIAVV GMACRYPGGV ASPEDLWRMV ADGRDVLSDF
PADRGWDIAE LFDADPDAPG KTYSRTGGFL AEAADFDAGF FGVSPSEALA MDPQQRLFLE
LSWEALERGG FDPAALRGSA TGVFTGIIAQ GYGVLAGAAA ADTEGFRLTG QAASVASGRV
AYVLGLEGPA VSVDTACSSS LTALHMAVQA LRLGECDLAL AGGVTINATP DIFVEFSRQR
GLSPDGRCKA FAGAADGTGF ADGGGVLVVE RLSDAQRLGH PVLAVVAGSA VNQDGASNGL
TAPNGPSQQR VVRAALANAG LGAADVDVIE GHGTGTTLGD PIEAQALLAT YGQGRPVDSP
VWLGSIKSNM GHTQAAAGVA GVIKMIMAMR NETMPPTLHV DAPSPHVDWS TGAVALLTEP
RPWPADHVRR AGVSSFGISG TNAHVIVESA PRTAAPQSEP SRPPVVPWVL SAKTPEALTC
QATRLADFLR AHPDADPLDV GWTLGGRTAF SQRAVVVGAD RDELLSALSD LDTCGSVRPG
AKTAFVFPGQ GAQVLGMGRE LHAAHPVFAA ALDAVIVELD RHLLRPLRDV MWGTNDELLH
STEYAQPALF AVEVALYRLL ESWGMTPDAV LGHSVGEISA AHVAGVLSLE NAAVLVVARG
RLMQRLPAGG AMVAVAASEA EIAALLPDGV DIAAVNGPDS VVLSGPEDAV TALADRLRAD
GRRVHRLAVS HAFHSALMEP MLPEFATVAQ GIPVSAPNID IISNLTGTLA EDDFGTSAYW
LRHVRQPVRF ADSVRSLAES GVVRFLEVGP ASGLTASIVA TLADSEPVTA SVMRKDRAEA
RSLMHALAEV FVSGAAVDWR AVCDGGQLTE LPTYAFQRRR FWLSGSGSAS DAVGLGQTRA
DHALLGAVVE LPDSGGVVLT GRLAVSTHPW LADHAVGGTV LFPGAGFVEL AIRAGDEVGC
TVVDELTLHA PLMLPAGGAA VRVVVGSDTD GVREVSLYSH DGVEGADWML HAEGILSSAT
VEPAVELSPW PPPAATSVDV AQTYPDLAER GYQYGPAFHG LRAMWRRGEE IFAEVALPND
LSANGFGVHP VLLDSALHAV LVAAERDELA LPFSWQKVRL FASGASALRV RIAPSGPNAV
SIDLADGLGL PVLSVQSMVA RPVTAEQLAA AVGGSRGAEL FEVVWSPVPD AGQSAPETDV
ILYDATATAT DLAFSPIATH RALERLKSFL TDASTAVLMV HTRGAIALPG ENVTDLSGAA
VWGLVRAAQT EHPGRIVLVD SDSDGDGETL DAAAIVATGE PQVVLRGGVL HRARVLPTRA
AVLTPPTDGP WRLGVSEAGT FENLVLESVA AQPLAAGQVR VAVRAIAANF RDVMMTLGVY
PGDGAIGIEA SGVVTEIGTG VTAVAVGDRV MGLFPEGTAT LAVTDARLLL PMPEGWGYPQ
AAGFPVGFAT AFFGLRELAQ VRPGQSVLIH AATGGVGLAA VQLARYWGLE VFATASRGKW
GTLRALGFDD DHIGDSRSLE FEGRFLAATG GRGVDVVLDS LAGDFVDASL RLLPRGGVFL
EMGKTDIRDA DAVAAAHPGV TYRAFDLFEA GAPGVQRILD GLQVLVDEGV CSPLPVTPFD
IRRAPAALRY LGQARHIGKV VMAMPDAWAA GTVLITGGTG MAGAAVARHV VDRHGARDLL
LVSRRGVAAP GADDLVADLE AAGARVRVVA ADVSDRDALA KVLADIDHRR PLSAVFHTAA
VLDDAVVTSL TPERIDTVLR AKSDAALHLH ELTKGYDLSA FVMFSSMAGL VGASGQANYS
AANATLDALA ARRRASGLPA ISLGWGLWDQ TSGLTGHLEN ADIARLGRDG ILAMTVADAL
ALLDTALVVN EPYLVPALID RAALRTKAAA GTLPPMFTTL IAGPARRQVG DALAAAQSRS
ALAQRLSGLP VEEQQGVLLD LVRSHMATVL GLPTPESIAP DLAFHDHGFD SLTAVELRNR
LKAATGLTLS PTLIFDYPTP AAIAGFFHSQ LVEEVEDSAP AVELDDQEIR EAVASIPVKR
LRQAGLLDLL LGMANEDGSS TGATREEAIA DMDLDDLLSA FDDDDE
//
