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Database: UniProt
Entry: A0A0M2KCE2_9GAMM
LinkDB: A0A0M2KCE2_9GAMM
Original site: A0A0M2KCE2_9GAMM 
ID   A0A0M2KCE2_9GAMM        Unreviewed;       463 AA.
AC   A0A0M2KCE2;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   16-JAN-2019, entry version 27.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:KKF36619.1};
GN   ORFNames=AV903_19350 {ECO:0000313|EMBL:AXF77706.1}, SY86_16105
GN   {ECO:0000313|EMBL:KKF36619.1};
OS   Erwinia tracheiphila.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Erwinia.
OX   NCBI_TaxID=65700 {ECO:0000313|EMBL:KKF36619.1, ECO:0000313|Proteomes:UP000033924};
RN   [1] {ECO:0000313|EMBL:KKF36619.1, ECO:0000313|Proteomes:UP000033924}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BuffGH {ECO:0000313|EMBL:KKF36619.1,
RC   ECO:0000313|Proteomes:UP000033924};
RA   Shapiro L.R.;
RT   "Erwinia tracheiphila.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AXF77706.1, ECO:0000313|Proteomes:UP000264980}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MDcuke {ECO:0000313|EMBL:AXF77706.1,
RC   ECO:0000313|Proteomes:UP000264980};
RA   Oliw E.H.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP013970; AXF77706.1; -; Genomic_DNA.
DR   EMBL; JXNU01000003; KKF36619.1; -; Genomic_DNA.
DR   RefSeq; WP_016192425.1; NZ_JXNU01000003.1.
DR   EnsemblBacteria; KKF36619; KKF36619; SY86_16105.
DR   PATRIC; fig|65700.7.peg.4039; -.
DR   Proteomes; UP000033924; Unassembled WGS sequence.
DR   Proteomes; UP000264980; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000033924,
KW   ECO:0000313|Proteomes:UP000264980};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117};
KW   Reference proteome {ECO:0000313|Proteomes:UP000033924}.
FT   DOMAIN      160    362       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      371    440       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     168    175       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
FT   COILED      322    342       {ECO:0000256|SAM:Coils}.
FT   COILED      440    460       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   463 AA;  52510 MW;  EF4B41F804332072 CRC64;
     MSLTLWQQCL ARLQDELPAT EFSMWIRPLQ AELNDNTLAL YAPNRFVLDW VRDKYLNNIN
     VLLNDFCGAD TPLLRFEVGS KPITRQISQP VVVGVHANAP AVDVRPAPLR PSWDNLPAPA
     ELSYRSNVNT KHNFDNFVEG KSNQLARAAA RQVADNPGSA YNPLFLYGGT GLGKTHLLHA
     VGNGIMARKP NAKVVYMHSE RFVQDMVKAL QNNAIEEFKR YYRSVDALLI DDIQFFANKE
     RSQEEFFHTF NALLEGNQQI ILTSDRYPKE INGVEDRLKS RFGWGLTVAI EPPELETRVA
     ILMKKADEND IRLPGEVAFF IAKRLRSNVR ELEGALNRVI ANANFTGRAI TIDFVREALR
     DLLALQEKLV TIDNIQKTVA EYYKIKVADL LSKRRSRSVA RPRQMAMAMA KELTNHSLPE
     IGDAFGGRDH TTVLHACRKI EQLREESHDI KEDFSNLIRT LSS
//
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