ID A0A0M2Q3W6_PROHO Unreviewed; 495 AA.
AC A0A0M2Q3W6;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=PROH_02685 {ECO:0000313|EMBL:KKJ01287.1};
OS Prochlorothrix hollandica PCC 9006 = CALU 1027.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Prochlorotrichales;
OC Prochlorotrichaceae; Prochlorothrix.
OX NCBI_TaxID=317619 {ECO:0000313|EMBL:KKJ01287.1, ECO:0000313|Proteomes:UP000034681};
RN [1] {ECO:0000313|EMBL:KKJ01287.1, ECO:0000313|Proteomes:UP000034681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CALU 1027 {ECO:0000313|EMBL:KKJ01287.1};
RA Shanker A., Yadav P., Khan S., Sharma V.;
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KKJ01287.1, ECO:0000313|Proteomes:UP000034681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CALU 1027 {ECO:0000313|EMBL:KKJ01287.1};
RA Syromyatnikov M.Y., Popov V.N.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKJ01287.1}.
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DR EMBL; AJTX02000002; KKJ01287.1; -; Genomic_DNA.
DR RefSeq; WP_017713914.1; NZ_KB235941.1.
DR AlphaFoldDB; A0A0M2Q3W6; -.
DR STRING; 317619.GCA_000332315_03729; -.
DR REBASE; 167979; M.Pho1027ORF2685P.
DR eggNOG; COG0286; Bacteria.
DR OrthoDB; 467945at2; -.
DR Proteomes; UP000034681; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:KKJ01287.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000034681};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KKJ01287.1}.
FT DOMAIN 6..133
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 140..460
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 495 AA; 55573 MW; 88745799A31898E0 CRC64;
MITGDLKSKV DKLWTTFWNN GISNPLSVIE QISYLLFIKR LDELQQTQER KANRLNRPLE
NPTFTPDQRA MRWSEFKNLD DAEAMLQVVR DQAFPFIKNL GESTEGSTYA KHMRDAVFLI
SSPALLASVV EQIDQIPMAD RDTKGDLYEY MLSKLSTAGT NGQFRTPRHI IKMMVALMAP
GPQEVICDPA CGTGGFLVVA AEYLRDLRDG EGNLVLNAPG NRDHYNTEMF HGFDFDGTML
RIGSMNLMLH GIEQPMIEKR DSLSENHSGV ADCFTMILAN PPFKGSVEKS TIAKDLTKAV
STTKTELLFI PLFLRLLKTG GRVAAIVPDG VLFGSSNAHK TVRQSLVECH KLDGVISMPS
GVFKPYAGVS TAILVFTKVG VKSGGTDFVW FYDMEADGYS LDDKRQPIAA NDIPHLLQCW
HDRDPAHLGD RRSKAFFVPR SEIETNGYDL SINRYKEIEY EEVTYEPPLV ILGQLRRLEA
EIQQDLDSLE RLLKP
//
