ID A0A0M2RL32_9ACTN Unreviewed; 828 AA.
AC A0A0M2RL32;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=LQ51_27565 {ECO:0000313|EMBL:KKJ94702.1};
OS Micromonospora sp. HK10.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=1538294 {ECO:0000313|EMBL:KKJ94702.1, ECO:0000313|Proteomes:UP000034330};
RN [1] {ECO:0000313|EMBL:KKJ94702.1, ECO:0000313|Proteomes:UP000034330}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HK10 {ECO:0000313|EMBL:KKJ94702.1,
RC ECO:0000313|Proteomes:UP000034330};
RA Talukdar M., Das D., Borah C., Deka Boruah H.P., Bora T.C., Singh A.K.;
RT "Draft genome sequence of Micromonospora HK10, isolated from Kaziranga
RT National park, Assam, India.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKJ94702.1}.
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DR EMBL; JTGL01000223; KKJ94702.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M2RL32; -.
DR STRING; 1538294.LQ51_27565; -.
DR PATRIC; fig|1538294.3.peg.932; -.
DR HOGENOM; CLU_002554_2_2_11; -.
DR OrthoDB; 4349881at2; -.
DR Proteomes; UP000034330; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR013587; Nitrate/nitrite_sensing.
DR InterPro; IPR010910; Nitrate/nitrite_sensing_bac.
DR PANTHER; PTHR44936; SENSOR PROTEIN CREC; 1.
DR PANTHER; PTHR44936:SF12; SENSOR PROTEIN CREC; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF08376; NIT; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50906; NIT; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KKJ94702.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..828
FT /note="histidine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005640925"
FT TRANSMEM 301..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..300
FT /note="NIT"
FT /evidence="ECO:0000259|PROSITE:PS50906"
FT DOMAIN 517..622
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT REGION 626..828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..667
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..786
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 828 AA; 87952 MW; 7EF169C3B01545B9 CRC64;
MGSRSTRLRT KVVALLVSLA ALWAFAAWVT LQDGLNVLGV QTLDAQVAEP SESLRTALQE
ERRMSVAYLG QPSPKQVEQL REQRRRSEEL AATFVTSARS WRARAAASDE LVQRIDEVAD
RLDSLGPVRD EVAARSIDRG AAAAAYSGVL DSLFRMYAAL GKLDDEDIAK DTSTLTQLVR
VRELMSQEDA LYSGVAAAGR ITDQEYILFA RLVGAQRFLA GEAIAELPAA DRDRYARMTA
DPAFIRLRAL EDRLMKDGRP DRPLPVTAAE WQAAITPALD EQESAVLAAG DSLVGRAKPV
AIWVIVRMVL AAGLGLIAVI ASIVVSITTA RALVRQLERL RDAAFRLANE QLPGVVERLG
RGDQVDVARE APPLEFGADE IGQVGRAFNV VQETAIRTAV EQAELRRSVR EVFLSLARRT
QALVHRQLTL LDAMERREHD AEELEDLFRV DHLATRMRRN AENLIVLSGS TPGRAWRRNV
PMVDVVRGAV AEVEDYTRVK VLPLGPVSLA GRAVGDVIHL LAELIENGLS FSPPHTTVEV
RGQLVGNGFA IEIEDRGLGM GEEELAAANH RIVDRSELNL ADAARLGLYV VSRLTERHGV
KVQLRESAYG GTTAVVLIPR ELVTDNGPDA ETSGGFRAGA GSGEGAPVTS SVEAEAGTES
ATVTGAAVPT AAETGLDSEP TPEPAEVAAE APRLTPSGLP ARVRRRPAPA APAGTSAGPA
AAPGGAAEPA AVPGGAAEPA ADGDGDGSTG SGLPVRVRQA SLAPELRVET ATVAGDPDED
TVRPPEQVRR MMTSYQSGTR RGRTDAARLL GGAQGVNAGP DPGDGQAT
//
