ID A0A0M2S6A0_9ACTN Unreviewed; 628 AA.
AC A0A0M2S6A0;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Propionyl-CoA synthetase {ECO:0000313|EMBL:KKK06803.1};
DE EC=6.2.1.17 {ECO:0000313|EMBL:KKK06803.1};
GN Name=prpE {ECO:0000313|EMBL:KKK06803.1};
GN ORFNames=LQ51_06040 {ECO:0000313|EMBL:KKK06803.1};
OS Micromonospora sp. HK10.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=1538294 {ECO:0000313|EMBL:KKK06803.1, ECO:0000313|Proteomes:UP000034330};
RN [1] {ECO:0000313|EMBL:KKK06803.1, ECO:0000313|Proteomes:UP000034330}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HK10 {ECO:0000313|EMBL:KKK06803.1,
RC ECO:0000313|Proteomes:UP000034330};
RA Talukdar M., Das D., Borah C., Deka Boruah H.P., Bora T.C., Singh A.K.;
RT "Draft genome sequence of Micromonospora HK10, isolated from Kaziranga
RT National park, Assam, India.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKK06803.1}.
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DR EMBL; JTGL01000057; KKK06803.1; -; Genomic_DNA.
DR RefSeq; WP_046563816.1; NZ_KQ058715.1.
DR AlphaFoldDB; A0A0M2S6A0; -.
DR STRING; 1538294.LQ51_06040; -.
DR PATRIC; fig|1538294.3.peg.1411; -.
DR HOGENOM; CLU_000022_3_5_11; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000034330; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0050218; F:propionate-CoA ligase activity; IEA:UniProtKB-EC.
DR CDD; cd05967; PrpE; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43347; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43347:SF3; ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000313|EMBL:KKK06803.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 113..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..58
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 62..446
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 511..589
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 628 AA; 67296 MW; E2858990A9AA903B CRC64;
MGAYRSAYER SLADPEGFWR DAAADLDWHR APERILDGGA APLYRWFPDG VLNTCHNALD
RHVAAGRGDQ PALIHDSPVT GTVRTLSYAE LLAETARFAG ALRRLGVGRG DRVLLYLAMV
PEAVIAMLAC ARIGAIHSVV FGGFAAHELA VRIDDARPTV VVATSCGIEV DRVVPYHPIL
AAALDEATHV PAHCVIVQRP QEPAPLLPGR DLTWDEAMAD AEPVECVPVA ATDPLYILYT
SGTTGRPKGV VRDNGGHAVA LRWSMRNVFD ISPGEVFWAA SDVGWVVGHS YIVYAPLLTG
ATTVLYEGKP VGTPDAGAFW RVVAQHRVAA LFTAPTAIRA IRRQDPDGAL LAGHDLSSLR
TLFLAGERLD PDTWEWAGQR LGVPVVDNWW QTETGWPVAA NPRGLEPLPI KPGSPSVPVP
GYDIRVVDGG GREVPPGTDG SIVIRLPLPP GCLPTLWGDD ERFLRSYLAT FPGHYLTGDG
GRFDEDGYLY VMGRTDDVIN VAGHRLSTGA MEEVLAAHPA VAECAVIGVA DPLKGQVPSG
YVVLKAGAEV DRDALAGELV ALVRQRIGPV AAFRRVTVVP ALPKTRSGKI LRRTMRGLVE
GRDEPVPPTI DDPAALTVFR DLGAEATP
//
