ID A0A0M2VEM1_9GAMM Unreviewed; 1034 AA.
AC A0A0M2VEM1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Efflux pump membrane transporter {ECO:0000256|RuleBase:RU364070};
GN ORFNames=VT06_08480 {ECO:0000313|EMBL:KKO49016.1};
OS Arsukibacterium sp. MJ3.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales; Chromatiaceae;
OC Arsukibacterium.
OX NCBI_TaxID=1632859 {ECO:0000313|EMBL:KKO49016.1, ECO:0000313|Proteomes:UP000034895};
RN [1] {ECO:0000313|EMBL:KKO49016.1, ECO:0000313|Proteomes:UP000034895}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MJ3 {ECO:0000313|EMBL:KKO49016.1,
RC ECO:0000313|Proteomes:UP000034895};
RA Lylloff J.E., Skov L.B., Jepsen M., Hallin P.F., Sorensen S.J.,
RA Stougaard P., Glaring M.A.;
RT "Draft genome sequences of two protease-producing strains of
RT Arsukibacterium isolated from two cold and alkaline environments.";
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU364070}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC ECO:0000256|RuleBase:RU364070}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942,
CC ECO:0000256|RuleBase:RU364070}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU364070}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKO49016.1}.
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DR EMBL; LAHP01000009; KKO49016.1; -; Genomic_DNA.
DR RefSeq; WP_046553867.1; NZ_LAHP01000009.1.
DR AlphaFoldDB; A0A0M2VEM1; -.
DR STRING; 1632859.VT06_08480; -.
DR PATRIC; fig|1632859.4.peg.1761; -.
DR OrthoDB; 9758297at2; -.
DR Proteomes; UP000034895; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF13; MULTIDRUG EFFLUX PUMP SUBUNIT ACRB-RELATED; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU364070};
KW Cell membrane {ECO:0000256|RuleBase:RU364070};
KW Membrane {ECO:0000256|RuleBase:RU364070};
KW Reference proteome {ECO:0000313|Proteomes:UP000034895};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364070};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364070}; Transport {ECO:0000256|RuleBase:RU364070}.
FT TRANSMEM 340..359
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 366..387
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 434..458
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 470..497
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 540..557
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 869..886
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 893..913
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 919..942
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 963..984
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 996..1022
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
SQ SEQUENCE 1034 AA; 110824 MW; 5CC639305DACC866 CRC64;
MANFFINRPI FAWVIALVIM LGGLLSIKQL PIEQYPRIAP PAISISASYR GASAQTAEDA
VTQVIEQAMN GLDNLMYMSA NSDSSGNISL TLTFETGTDA DIAQVQVQNK LQQALPLLPQ
EVQQNGVRVA KSSGGFLMVV AFISEDGSLE RDDIADFVVA NIKDPLSRTN GVGNVQVFGS
QYAMRVWLDA DKLNQYQLTP ADVTAAIKVQ NNQVTAGQLG GAPALPGQQY NAAILAQTRL
TTAEEFGQIL LKVNADGAMV KLSDVARVEL GGEDYSVIAR YNGKMATGLA IELATGANAL
DTAAAVKAKL AELAPYFPAG LATVIPYDTT PFVEVSINSV VQTLIEAIIL VFLVMYLFLQ
NFRATLIPTL AVPVVLLGTF GIMSLFGFTI NTLTMFGMVL AIGLLVDDAI VVVENVERVM
SEEGLSPVEA TRKSMGQITG ALVGIGLVLS AVFVPMAFFG GATGAIYQQF SITIVTAMAL
SVLVALIFTP ALCATMLKPI KGGQHAKRGF FGWFNRGFEH TNNNYQRGVA GMLARPKRSM
LVYGVIVAVM AFMFMRLPTS FLPEEDQGVF LSLIQLPTGA SQERTEAVMD KVAAHYTSEA
AVQSVFTVSG FSFAGRGQNM GLAFVRLTDW DERGPADSVQ AVIGRASGFF STVKEAQIFA
FNLPPIAELG RATGFSLFLQ DRGGVGHNAL LNARNQLLGM AAKQQNLVSV RPNGMEDAAQ
LKIEVDQLKA QALGVSLSNI NQTLAIGWGS TYVNDFVDRG RIKKVFVQAE PEFRMTPEDI
NRWYVRNNNG EMVSFASFAS SNWVYGPQRL ERYNGVSAME IQGEPAPGAS SGDAMATMEQ
LISQLPAGIG FEWTATSYQE KLSGSQAPAL YALSILVVFL CLAALYESWS VPFAVILVIP
LGIIGALIAA NMRGMGNDVY FQVGLLTTMG LASKNAILIV EFARELQQQG KELTAAILEA
VRLRLRPIIM TSMAFSLGVL PLVISSGAGS ASRNAIGTGV LGGMISATIL AVFLVPVFYL
VVMKLFSRSA RAEH
//
