ID   A0A0M3HVD1_ASCLU        Unreviewed;       644 AA.
AC   A0A0M3HVD1;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Amiloride-sensitive sodium channel subunit alpha {ECO:0000313|WBParaSite:ALUE_0000688901-mRNA-1};
OS   Ascaris lumbricoides (Giant roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX   NCBI_TaxID=6252 {ECO:0000313|Proteomes:UP000036681, ECO:0000313|WBParaSite:ALUE_0000688901-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:ALUE_0000688901-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC       ECO:0000256|RuleBase:RU000679}.
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DR   AlphaFoldDB; A0A0M3HVD1; -.
DR   WBParaSite; ALUE_0000688901-mRNA-1; ALUE_0000688901-mRNA-1; ALUE_0000688901.
DR   Proteomes; UP000036681; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690:SF273; DEGENERIN LINKED TO MECHANOSENSATION; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        74..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        495..519
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   644 AA;  73361 MW;  64BBE3FED3BC8B93 CRC64;
     MTIRVDDNRG PAMHHRVYAK VVSEHLLEIP VDHLKRIAHT EGVNSIQRET KHFSYSTTLH
     GPLRLYQGKG FGKVFWGLVM AAALIFLSLQ INILVTDFLS HPTTTSVSFV GRQALTLPAV
     TICNYNPIKK DYVRYLNESS SGKGLFTRNL LRYMIIAYTQ VEDLYLHADS EALRLGKQDY
     DVFKSVFTEY SFNIENFFAH SGFTCAEMLK VCSLGGIKFD CCRMSKRVLT DLGWCFAFSV
     GNITIKQRLP GIFNGLQVIL DAGINETVDI TYTKGGAIPM FSNNIENGFR IYVRNRHELA
     YASTEALTLS PSHRGYVALS LQKFHFLTPD KWGNCTNEWP QNSPFRAYDL PYTAQNCASL
     CQQVYYEEKI NCTPMLYSIG NPNLATCTPS ELHDFMLQVV NRSNNINGPE CEDNICPTSC
     ITYTYSSSIS YGQGFSDSAL KWLQAMNSEW TEDRVNTNFA VLNVFYREMS YIVNEQVQST
     SLANVLSNIG GNMGLFFGAS VITVAELAIY ISKMCWIIIS RKRREYMARK KKNELEREQR
     LRELLENAAA NTTTPNTRET PLYESVMLRL RDDTDKKSDE DSIDDSKMRR SALCSHNITT
     RDRATSSSNY VDPHSFDLYY FNDDEIVAHK NGDPSYENWQ IKDH
//