ID A0A0M3I2Z2_ASCLU Unreviewed; 722 AA.
AC A0A0M3I2Z2;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 2.
DT 08-NOV-2023, entry version 34.
DE RecName: Full=protein-serine/threonine phosphatase {ECO:0000256|ARBA:ARBA00013081};
DE EC=3.1.3.16 {ECO:0000256|ARBA:ARBA00013081};
OS Ascaris lumbricoides (Giant roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX NCBI_TaxID=6252 {ECO:0000313|Proteomes:UP000036681, ECO:0000313|WBParaSite:ALUE_0001094001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:ALUE_0001094001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (MAY-2016) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001482};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC {ECO:0000256|ARBA:ARBA00009580}.
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DR AlphaFoldDB; A0A0M3I2Z2; -.
DR WBParaSite; ALUE_0001094001-mRNA-1; ALUE_0001094001-mRNA-1; ALUE_0001094001.
DR Proteomes; UP000036681; Unplaced.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0030837; P:negative regulation of actin filament polymerization; IEA:InterPro.
DR CDD; cd14513; DSP_slingshot; 1.
DR CDD; cd11652; SSH-N; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR014876; DEK_C.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR043587; Phosphatase_SSH-like.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR043588; SSH-N.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR45864:SF2; PROTEIN PHOSPHATASE SLINGSHOT; 1.
DR PANTHER; PTHR45864; SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG; 1.
DR Pfam; PF08766; DEK_C; 1.
DR Pfam; PF00782; DSPc; 1.
DR SMART; SM00195; DSPc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF109715; DEK C-terminal domain; 1.
DR PROSITE; PS51998; DEK_C; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912}.
FT DOMAIN 306..361
FT /note="DEK-C"
FT /evidence="ECO:0000259|PROSITE:PS51998"
FT DOMAIN 446..587
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 508..565
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 595..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 722 AA; 82070 MW; 62D3EB39B91BF4F8 CRC64;
MSLVTVQRSP TPSENANFDH SDADVCECGL SPRKSKSVAS SECFFYVKGT AVILLNHDRT
NVAHNSANGE IEEHLQAMLR MLPPEDTLTM AVRLQPNSDQ DCLQDHARYL AVVASSSRQD
IDDSRDAREC VLLGLDCLPG DKATIGVVIP IFASTHVRLD GDGGIAVDCD SSYHLFRPVS
VQAMWTMFQC LHKELREVQG AKNSPSQTAR PGERLVDYYL RHISSQDAIR AEWERSSSEY
GIGTSSDLGA TTADAERFSI EGRGNDNSVE AQIHDRLKEV MQTVDLDDVT SKDIRMKVHI
FVDFFERLEA QIHDRLKEVM QTVDLDDVTS KDIRMKVEES MGINLDDYKD FISRQMMVIM
GQMDKASQIF PYLYLGTEWN ACDWQWLENN GAHSKCFAIY ESHLNHKDWH RILLRVEVEE
SMGINLDDYK DFISRQMMVI MGQMDKASQI FPYLYLGTEW NACDWQWLEN NGVQYIVNVT
NEVENFFPAR LKYLKIRVCD EASTELLKHW NQTNQFIKEA KEKGSAVLVH CKKGISRSSS
TVIAYAMKEY GWGLSQAMEH VKKKRDCITP NKGFVEQLKT FEGMLDAFKK REQFDAPPST
STILPESPMR SERRQPRRKH LMSYHISHNI VDVASPICSC NRLSEHGSTV RSLVGSFEAK
GRGDDSARLT SRTSDTHLER PPVTFRLEKL TDWKTRHSLA VSMPPSCTNT SISQIRALTI
SQ
//