ID   A0A0M3I646_ASCLU        Unreviewed;       390 AA.
AC   A0A0M3I646;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Tumor susceptibility gene 101 protein {ECO:0000313|WBParaSite:ALUE_0001247801-mRNA-1};
OS   Ascaris lumbricoides (Giant roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX   NCBI_TaxID=6252 {ECO:0000313|Proteomes:UP000036681, ECO:0000313|WBParaSite:ALUE_0001247801-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:ALUE_0001247801-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UEV
CC       subfamily. {ECO:0000256|ARBA:ARBA00009594}.
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DR   AlphaFoldDB; A0A0M3I646; -.
DR   WBParaSite; ALUE_0001247801-mRNA-1; ALUE_0001247801-mRNA-1; ALUE_0001247801.
DR   Proteomes; UP000036681; Unplaced.
DR   GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR   GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 6.10.140.820; -; 1.
DR   Gene3D; 6.10.250.370; -; 1.
DR   Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR   InterPro; IPR037202; ESCRT_assembly_dom.
DR   InterPro; IPR017916; SB_dom.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   InterPro; IPR008883; UEV_N.
DR   PANTHER; PTHR23306:SF3; TUMOR SUPPRESSOR PROTEIN 101; 1.
DR   PANTHER; PTHR23306; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED; 1.
DR   Pfam; PF05743; UEV; 1.
DR   Pfam; PF09454; Vps23_core; 1.
DR   SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR   SUPFAM; SSF54495; UBC-like; 1.
DR   PROSITE; PS51312; SB; 1.
DR   PROSITE; PS51322; UEV; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          8..151
FT                   /note="UEV"
FT                   /evidence="ECO:0000259|PROSITE:PS51322"
FT   DOMAIN          324..390
FT                   /note="SB"
FT                   /evidence="ECO:0000259|PROSITE:PS51312"
FT   REGION          152..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   390 AA;  43837 MW;  934E0FB45654A7BD CRC64;
     MFRNSMNNAS QVVAVLNRTR AKYVDSAKSD ILTALNFFPD LSPDAENFTF PDGTRSLTFR
     LKGTIPVLYK GNTYNIPVAL YLWDTHPYYA PICYVCPTPN MVVKESKTVD KQGRIYLPYL
     TDWRYPGYDL SGLLQVMALC FRDSCPVFAK PTSTPQRTTS ASASSTPQTQ PSYTPYPMSA
     SVGMPPYPIN SPQTPQYPAY QPPYPNAFPS IPVVQPPPHA IGTIQPEHLK ASILSAVEDK
     IKQRLREKLG TVHAELASIR QTHAELRAGQ QRLKSICDGL ASEQKQMEES LLIYQEKKAE
     ISSIISAHPE DVSVDIDSLI DACTPLHKQL LRCYVYDCAI DDTIYFLGQA LKQGKMTLPN
     YLKEVRQLSR KQFIYRATLQ KCRLKAKLPT
//