ID A0A0M3IAW1_ASCLU Unreviewed; 308 AA.
AC A0A0M3IAW1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Pept_C1 domain-containing protein {ECO:0000313|WBParaSite:ALUE_0001476601-mRNA-1};
OS Ascaris lumbricoides (Giant roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX NCBI_TaxID=6252 {ECO:0000313|Proteomes:UP000036681, ECO:0000313|WBParaSite:ALUE_0001476601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:ALUE_0001476601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR AlphaFoldDB; A0A0M3IAW1; -.
DR WBParaSite; ALUE_0001476601-mRNA-1; ALUE_0001476601-mRNA-1; ALUE_0001476601.
DR Proteomes; UP000036681; Unplaced.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF878; PROTEIN CBG15672; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 14..64
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 96..307
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 308 AA; 35292 MW; 883922DE55B86A92 CRC64;
MTQRVRDLRI STFRYDRQYS SNDETRLRFR NFVRNMKFIK KAQKGRDNVV FGITRFTDWS
EAEMKSMTCE DWAANEVGSE ITLDDDQDES DEVFDRPDAF DWRTKSVVTD IKDQERCGSC
WAFAAIGVVE SMNAIAKNPL ISLSEQELID CDTDDNGCSG GYRPYAFRYV RRHGIVSEKD
YPYKGKEQSQ CAANGTRVYI KSVKYIGRNE DAMADFVFYR GPISVGINVT KEFFHYRSGV
FTPKKEDCEE DSQGSHAVAV VGYGSQNGED YWLIKNSWGK KWGMDGYVLY KRGENCCGIA
NTPFSVEA
//
