ID   A0A0M3IKG8_ASCLU        Unreviewed;      1019 AA.
AC   A0A0M3IKG8;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0000313|WBParaSite:ALUE_0001923701-mRNA-1};
OS   Ascaris lumbricoides (Giant roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX   NCBI_TaxID=6252 {ECO:0000313|Proteomes:UP000036681, ECO:0000313|WBParaSite:ALUE_0001923701-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:ALUE_0001923701-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the NTE family. {ECO:0000256|ARBA:ARBA00006636}.
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DR   WBParaSite; ALUE_0001923701-mRNA-1; ALUE_0001923701-mRNA-1; ALUE_0001923701.
DR   Proteomes; UP000036681; Unplaced.
DR   GO; GO:0004622; F:lysophospholipase activity; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0046470; P:phosphatidylcholine metabolic process; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR001423; LysoPLipase_patatin_CS.
DR   InterPro; IPR002641; PNPLA_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR14226:SF29; NEUROPATHY TARGET ESTERASE SWS; 1.
DR   PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 2.
DR   PROSITE; PS51635; PNPLA; 1.
DR   PROSITE; PS01237; UPF0028; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          1..43
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          49..145
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          452..616
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000259|PROSITE:PS51635"
FT   REGION          782..817
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        782..798
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1019 AA;  114617 MW;  3E3CC023F94A2CE8 CRC64;
     MVHPRELIGG LQLLTSEPSF HTVRTHTAAT IAILNKEDFA ELLEIRPEVI LPVAESVIRR
     LSPFLRSVDF AIDWVLLDSG QAVYRSGDVS DSLFVVLSGR LRSVEKKMLV EEFGRGDMIG
     MVEVLQRVPR STTVLAIRFS QLARIPEGLL NYIKMKFPQV GFRLVHLLGH YYSSSNRRTM
     VANTGFTDHL SGPIGDPRSH IKNLHTVAVI AASANVPLVP FTCELYNALN ASLRVLRLSS
     KKVAEHLDPS VLEKPESIXL NASLRVLRLS SKKVAEHLDP SVLEKQADFR LMHWLNVQED
     TFPLVIYECD NMATNWTRRC LRQADAILLV ANGQQKPMKQ SFVRLFGHLF LRMMEEFLSI
     NPDWVRTNKE LILLWDEDTV APQGTIEWLK GSWFSGHHHI RCPKRMTQWN PSTVTEREVI
     DYYEENVFWD KVDNNSDFAR LARILTGNAV GVVLGGGGAR GASHVGILRA IREHGIPIDF
     IGGTSMGAMI AGLYAESDMD VEQRAKEWFM LMNSLWPKIW DLTYAHSAMF TGAGFNKTVQ
     AAFSDIAIED LWLSYFCITT DISDSEMRVH RSGPLWAYCR ASMSLAGYLP PLCDPVDGHL
     LLDGGYVNNL PADVMRSLGA RVVIAVDVGA ASENNLLNYG DSLNGFWVLF KKLNPFGEPV
     KVLNMEEIQS RLAYVSCVRQ LEQVKKAPYC HYLRPPITQY ETLDFAKFDE IYEVGYKYGS
     EKFDELVKKS DLLKNIIGPE VLRSLKLQQS RRELSKLANY DRSLASSFTN LAAQVSKIPK
     VASKDSSNSG NSSDDENNAA EGWWPRSGQH SPDDLRASYV MDDEVEGYVS EPCSGYRYRA
     HRSLYVDDDQ SSTEEEDVGI RATVPXQMIS VLPIGYRYRT HRSLYVDDDQ SSTEEEDVGI
     RATVPIVVSG MSIALKRRQT CAEIPAVTEQ EALTMELRIP QRRRRTLTDF TDELHRMNDI
     LHAGGDFVIE TSNAFTYNTT SVKTTRSKAS IIDVGNFLFH LVVAGIVASE ILMRMAVVT
//