ID   A0A0M3JSU9_ANISI        Unreviewed;       714 AA.
AC   A0A0M3JSU9;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=PKD_channel domain-containing protein {ECO:0000313|WBParaSite:ASIM_0001107501-mRNA-1};
GN   ORFNames=ASIM_LOCUS10633 {ECO:0000313|EMBL:VDK43349.1};
OS   Anisakis simplex (Herring worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Anisakidae; Anisakis;
OC   Anisakis simplex complex.
OX   NCBI_TaxID=6269 {ECO:0000313|Proteomes:UP000036680, ECO:0000313|WBParaSite:ASIM_0001107501-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:ASIM_0001107501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDK43349.1, ECO:0000313|Proteomes:UP000267096}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; UYRR01031009; VDK43349.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0M3JSU9; -.
DR   WBParaSite; ASIM_0001107501-mRNA-1; ASIM_0001107501-mRNA-1; ASIM_0001107501.
DR   Proteomes; UP000036680; Unplaced.
DR   Proteomes; UP000267096; Unassembled WGS sequence.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR   CDD; cd21050; ELD_TRPML; 1.
DR   Gene3D; 1.10.287.70; -; 1.
DR   InterPro; IPR049134; MCLN_ECD.
DR   InterPro; IPR039031; Mucolipin.
DR   InterPro; IPR013122; PKD1_2_channel.
DR   PANTHER; PTHR12127; MUCOLIPIN; 1.
DR   PANTHER; PTHR12127:SF7; SD02261P; 1.
DR   Pfam; PF21381; MCLN_ECD; 1.
DR   Pfam; PF08016; PKD_channel; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000267096};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        323..349
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        378..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        413..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        455..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        536..558
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          121..304
FT                   /note="Mucolipin extracytosolic"
FT                   /evidence="ECO:0000259|Pfam:PF21381"
FT   DOMAIN          402..562
FT                   /note="Polycystin cation channel PKD1/PKD2"
FT                   /evidence="ECO:0000259|Pfam:PF08016"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          683..714
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   714 AA;  81256 MW;  C0A81C9D258DCB61 CRC64;
     MPGRPGRRPR STSATGTYRT VPTDRETTTG DLTGTSWMTA SESVGGFCAG SEVNDNEYVH
     ILADLSEQDR NIGERLRRHL QFFFMDPLMK WRVRRQFPFK LFLQILKIIF ITIQAIYPPS
     SGRYSVFTGP DIINQFAFMI DSYYMLQEES FASFSYDTSL IHREKRTLNE TAAVVNKISF
     DQIPFLELCI HRIANVTVFN DTYEFDISEI DGCFKLNFTE EEVQKVHNNS WSLEEILRVR
     GITFKPEDAL IISKAELKFK LRTIHFSPVS TDQRPECYLI AVTITFDNSR HTGQVFISLS
     TEISYVNLCN GRILQGGGLA TDAIVIGVID VIVLMLCIAS LMLCCRALIR AHLLKMTTCD
     YFECVLKRKL ALSDELEFLN LWYVMIVIND ICIALGTVFK ISIEFRDFDS DLFTTTGILL
     GIGALLVYVG VLRYFCFFSK YNILILTMKR ALPNILRFMS CAAVLYMGFL IAGWVIIGPY
     SLKVSDFLFF SSRFMPFRTL GKSSEALFSL LNGDDMFATF FTINDSNTTI KIFGTIYIYV
     FVSLFIYVVL SLFIAIIMDA YEIIKEHYNG DLKMEYSALR AFANSDSTNV QQQISSDEIR
     QQFSPRNLIR LGYTVDTTEC FNIFSRFRDW YRTKRANGTN DSANGTPSTT NFPYNSFTNP
     NLIQAQHPPT TTTAILPCSA SDHQYQHTTT NDDPPIQIEG LSSPTTNNDT SVIT
//