ID   A0A0M3JVR2_ANISI        Unreviewed;       564 AA.
AC   A0A0M3JVR2;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   24-JAN-2024, entry version 32.
DE   SubName: Full=Putative cytosolic purine 5-nucleotidase (inferred by orthology to a S. mansoni protein) {ECO:0000313|WBParaSite:ASIM_0001232401-mRNA-1};
GN   ORFNames=ASIM_LOCUS11790 {ECO:0000313|EMBL:VDK45822.1};
OS   Anisakis simplex (Herring worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Anisakidae; Anisakis;
OC   Anisakis simplex complex.
OX   NCBI_TaxID=6269 {ECO:0000313|Proteomes:UP000036680, ECO:0000313|WBParaSite:ASIM_0001232401-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:ASIM_0001232401-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDK45822.1, ECO:0000313|Proteomes:UP000267096}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR017434-2};
CC       Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR017434-2};
CC   -!- SIMILARITY: Belongs to the 5'(3')-deoxyribonucleotidase family.
CC       {ECO:0000256|ARBA:ARBA00009589}.
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DR   EMBL; UYRR01031102; VDK45822.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0M3JVR2; -.
DR   WBParaSite; ASIM_0001232401-mRNA-1; ASIM_0001232401-mRNA-1; ASIM_0001232401.
DR   Proteomes; UP000036680; Unplaced.
DR   Proteomes; UP000267096; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd07522; HAD_cN-II; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 2.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR008380; HAD-SF_hydro_IG_5-nucl.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR016695; Pur_nucleotidase.
DR   NCBIfam; TIGR02244; HAD-IG-Ncltidse; 1.
DR   PANTHER; PTHR12103; 5'-NUCLEOTIDASE DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR12103:SF15; CYTOSOLIC PURINE 5'-NUCLEOTIDASE; 1.
DR   Pfam; PF05761; 5_nucleotid; 1.
DR   PIRSF; PIRSF017434; Purine_5'-nucleotidase; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|PIRSR:PIRSR017434-2};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR017434-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000267096}.
FT   REGION          513..564
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        537..551
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        46
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR017434-1"
FT   ACT_SITE        48
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR017434-1"
FT   BINDING         46
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR017434-2"
FT   BINDING         48
FT                   /ligand="GMP"
FT                   /ligand_id="ChEBI:CHEBI:58115"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR017434-2"
FT   BINDING         336
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR017434-2"
SQ   SEQUENCE   564 AA;  64841 MW;  A78F81FF42BE7C4D CRC64;
     MGDNRLRYLS TCSEDGTRRT YKRSPAQRIF VNRNLRMEKI KFFGFDMDHT LAVYKSPDLE
     IMTFDMVVER MISIGYPDDL RSFKYKPLFP VRGLWFDHLY GNLLKVDGFG NILFGIHGFR
     FMQPSEIEDL YPNKFLHLSD NRVYVLNTLF NLPETYLVAC LVDYFDSSEQ YVSTDDKTGV
     KCGEMFMSYR SIFQDIRTAV DWVHFDSNMK TIILNNLDKY VVKDARIKQL LLQIKQSGKQ
     SFLLTNSDYT YTNGMMKYLL GDDWTSYFNI TVVSAHKPKW FAEGTVFREV NLKTGDLKIG
     IHTGPLKQGV VYSGGSCDAF RRLVKARGKD VLYIGDHIFG DVLRSKKARG WRTFLVVPEL
     NQELMVWTER KPLFDRLNAL EAVLADAYKD LDSNAKEKPV ITTIVEAIKS LSNEMDNEYG
     ILGSLFRSGS RTTFFASQVE RYADVYAASC YNLVHYPLFY FFRAPMTLMP HESTVDHDSV
     MQPLHNTASC TSRHNSIGQQ VRGLKLQATP FCHEEEEEEA TSNSDNETEK RDMTSLSDDL
     PSQLNNSDIV HSATVHEDKN ISAD
//