ID   A0A0M3JWB0_ANISI        Unreviewed;       833 AA.
AC   A0A0M3JWB0;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   27-MAR-2024, entry version 40.
DE   RecName: Full=Forkhead box protein O {ECO:0000256|ARBA:ARBA00039893};
GN   ORFNames=ASIM_LOCUS12028 {ECO:0000313|EMBL:VDK46382.1};
OS   Anisakis simplex (Herring worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Anisakidae; Anisakis;
OC   Anisakis simplex complex.
OX   NCBI_TaxID=6269 {ECO:0000313|Proteomes:UP000036680, ECO:0000313|WBParaSite:ASIM_0001256201-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:ASIM_0001256201-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDK46382.1, ECO:0000313|Proteomes:UP000267096}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-
CC       ProRule:PRU00089}.
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DR   EMBL; UYRR01031130; VDK46382.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0M3JWB0; -.
DR   WBParaSite; ASIM_0001256201-mRNA-1; ASIM_0001256201-mRNA-1; ASIM_0001256201.
DR   Proteomes; UP000036680; Unplaced.
DR   Proteomes; UP000267096; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd20032; FH_FOXO; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR45767; FORKHEAD BOX PROTEIN O; 1.
DR   PANTHER; PTHR45767:SF2; FORKHEAD BOX PROTEIN O; 1.
DR   Pfam; PF00250; Forkhead; 2.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 2.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 2.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00089}; Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000267096}.
FT   DOMAIN          227..279
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000259|PROSITE:PS50039"
FT   DOMAIN          431..524
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000259|PROSITE:PS50039"
FT   DNA_BIND        227..279
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT   DNA_BIND        431..524
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT   REGION          93..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          136..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          508..530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          650..713
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        154..174
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        186..225
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        650..706
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   833 AA;  90378 MW;  44872285A9626AB7 CRC64;
     MPVNSNGSNM SAVQLLSSSS TNSNSASRLI NVTSAISTTS NSCIKMEDIS ISQQQSTSAI
     NPSVLSSHTP INNINSAASV NDQNCINSST NRFRLPNASP NPENNAMESD DLGPVSRDRC
     NTWPLRRPQL DINAQTSPLI HEQIPEEDND LYDSTESISN GRLGANSTAG LMGSPDNGAF
     SPGMSSPVPC GNTSGQVPPS SAGSDTSDPG TTAPGSNKKS TTRRNAWGNM SYADLITQAI
     MSSAEKRLTL SQVYEWMVQN VPYFRDKGDS NSSAGWKKTS ASEADEECKC ETLDMESIAR
     NGSICAYDDE LESESESESE SRSRCYTWPM QQLCSVSTTN KPTDPPPPVL HASTDRQLPS
     SDHLLDNLSH RRTATIASTA TSPHLIHNDI SSLCSASDGG NLSSPLLTIQ KKRVRKRTTD
     QVANQKKPNP WGEESYSDLI AKALECAPEK RMKLNEIYLW FSTNISYFRD KSSTEEAAGW
     KNSIRHNLSL HSRFMRIQNE GAGKSSWWVI NPDAKPGRNP RRQRSATLEN TTKAAIEKKR
     RGARKKAMEL RAAGTLHSAS SSVVGSQASI ISHELYGDND DSLGNFEPLF RPRTQSNLSI
     TASSSRVSPS MTTDHFDDFD FPPFVEAGAM PHDILDRTNE MNLNTHPESS VFQRAGHNPM
     LNGSVNQSQA QSQPSAASSS SSASSLLQHI KSEPTPPNSI KNEANGVQPP PSYHELNAVR
     GVSHLQNPLL RTHLIQNRLP PPAGLPYNGL YSTATGTALP NWIHTGGAQL IPGLHSQISC
     SAQQTLGPTA ALPLDLENLT LPDQPLMELD NMEAVLRHEL SQSTSNQLSF DNI
//