ID A0A0M3JYQ0_ANISI Unreviewed; 7110 AA.
AC A0A0M3JYQ0;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Titin {ECO:0000313|WBParaSite:ASIM_0001358501-mRNA-1};
GN ORFNames=ASIM_LOCUS13013 {ECO:0000313|EMBL:VDK48693.1};
OS Anisakis simplex (Herring worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Anisakidae; Anisakis;
OC Anisakis simplex complex.
OX NCBI_TaxID=6269 {ECO:0000313|Proteomes:UP000036680, ECO:0000313|WBParaSite:ASIM_0001358501-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:ASIM_0001358501-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDK48693.1, ECO:0000313|Proteomes:UP000267096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UYRR01031295; VDK48693.1; -; Genomic_DNA.
DR WBParaSite; ASIM_0001358501-mRNA-1; ASIM_0001358501-mRNA-1; ASIM_0001358501.
DR Proteomes; UP000036680; Unplaced.
DR Proteomes; UP000267096; Unassembled WGS sequence.
DR CDD; cd00096; Ig; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 19.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR47633:SF7; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47633; IMMUNOGLOBULIN; 1.
DR Pfam; PF07679; I-set; 15.
DR SMART; SM00409; IG; 16.
DR SMART; SM00408; IGc2; 11.
DR SUPFAM; SSF48726; Immunoglobulin; 20.
DR PROSITE; PS50835; IG_LIKE; 15.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000267096}.
FT DOMAIN 84..170
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 428..515
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 674..761
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1042..1131
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1153..1245
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1278..1366
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1489..1573
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2080..2163
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3795..3870
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3900..3989
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4006..4105
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5369..5458
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5509..5598
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5613..5700
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5969..6049
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 580..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2605..2639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2883..2905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3013..3035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3156..3177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3352..3371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3387..3407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3466..3485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5482..5511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6167..6206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2750..2777
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3202..3229
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2618..2639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3162..3177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3391..3407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6170..6194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 7110 AA; 801729 MW; B1B6A1DAA1A912F9 CRC64;
MKLEEKGNWT TVTMIQSDGS QVPSSKLERD ATTSYATNRE TVYHKNARTV EETHLIKSAG
SSNQGFSEEH WSSEIKSFVT AQPPKFIQVI KAFRVLATDT LTLVVEVESD PPAIFEWFCN
DRSVQQDKRR FKVRHGLNIT TLTVEGPEQG VYKCTARNPA GISTTYGYIT VNAQPQYQKW
TQQKHAVVIE ESYETTSSEQ IGVTIKQAPK FVNGVPNLTL KPGAEAIIDV EVDAYPPAKF
TWYVNGYEFR DSSGRIAIYY PKENRCVARF PIPQTGEYKV VAENSLGKDQ SIGYIDIKKE
ISVHQTERPP LPVESVRHTG TLPLQRHQNL FDGTDFMRSS SVSKNYEMYE ESSYYQRSTS
LPRPVHSIER HVQMTSDAGK HHEEEVKGQL PYSSMTEIYR AVDREDGRTE TLYRTVSSES
THTMPQPPKF TSALPKAVSL SPSDELVLSV DVKAAPQADI KWKFDGSDVK ESKNVTILSE
HNRSTLIAKP PVQQGRYSVE VTNEAGTISS ATTVHRVEEE TFEQVDEHTI ISERGSAVRS
RSSPPPEIVE NAITVTSAQD GWELVDRADL MKSSSGSVET VKHVETSTKY SVSDDRKAAP
PVPPKPAPVQ ISSFTYTQKV SEESGDLSMK QSAIIPQPKT TTTQTTEMFA TEMIEERRQM
QPSRKVSEPL PKRPQVLRQP PPEVHVKAGE KLVLESKVDS YPESSFKWYQ NNFEVRPSAS
VQIEAPAPNE SRAIFKKPTD GIYKVTASNV YGSCTSSTRV TTEVVEEMLE ESSVSIIRTP
AQQVQPQQHI QKFQFVRKGR VEPRKDLPKV PKIHKKFASL IRIPQHKPLV LSVEADAIPE
ATFTWRVNNF EVRPSALVHI ERPAPNVCRA TFTKPSEGRY EVIASNERGT DVCSTKVAID
YDTEVVSEKR TTIQQVIQPT PEPPVFVRSL PPRTQLSDTE IKEFQLNVLV DSQQPVTFRW
FADGSLLSNS VEHQMINEAF ESTLLVRQPI RRVRDYSVEV SNASGTIRST TSVYPPITTR
TSSTIEELLA TEASTEVRQR APRFTTPLYA TELEEGERLT AEVVVDHDGA PCEFLWYLNG
KDVRTQPGFR VDSTHYVSTL VVESVNARTD GKLSVIATNR YGTAESSATI TVNKREDTFE
VITVSPTPAE RPPKIVSPLH STVFTAGQPM TLRCHIDALP PAQIIWTKDE VDLAEWVINE
DITTNILPDG TYELTKPECT PDDAGLYECS ARNAYGTAQT AAYVTVEEMV YTKDVHEAEI
HEIAITKSPS PYVPQEPPRF TETMTSEIED EKTVLKCKVH SEAPVEISWY HNNVPLTQNE
KYTMRSFVDG TQTLSVRDVS KRDEGVYMCR AESRYGVAET SSQVITKEER QIREEEVLIE
EHTDEQIQLP QRTDFQKKVY TDTSVKLISE TEITDSEENY SRTAELKKNE EEYKLLVKVA
ETVAKRLVAN IVIEEAVREA AYRIREQIHT SDEEEIFIER TTEERTYAPR FETNIECQTV
RVGDTVRFAT DVRGHPTPRI HWYFGQQRIQ QSDHTEVLCL NGRSTLVIRR VTKEDEGVYF
CEAENRVGKA VLSCDLRVID TSTGGNIVLQ RFQSTLDFSR TAEYVSTETE TEVHSNILVN
HSEEAFEHRI SFLQPRTISL GYDCRASTSK VYDDSVIIRR EERRQRLEPA HKEVTLNVNV
EKPTPQFKHD VQILQQRETD ISMLTNEQWF VSSEEVMQTR DITLTEKQKR AYGQDSTVNI
STTIVIEKPS QRALHEVICI YDERVRLPEE RFHAVRSVEL RQMEEVNELF TSVLARKDEH
QAHEVANVEV RRPPSQFDHT TTVMESEVAH LCAHYTAPTT SRSEIVVVEV NLVKYSPVLS
DRVTRIQRPI RRATAEQRIV ILEGVTESFS EEVFWSLKKI QKAVTHTGEA ITNANIEVRK
PFEQGEHITT IIDKVKIIPE ILAIAAAATK IQITNVYITL TKKGEVAHQA LVIEYESYIE
DEASLNIALL TVPAFHSKQE EIWTRETRIK ETYDERNIVA VFVEVDANCP NQSVELVASV
NIPVISNANL SGIQRWSTSS VVERSDSITE SSSYGVFEAP RFLKQLENVT TAIGNALQFK
CIVSGMPMPE IRWFVDGDEI HTSRVYETVY EDGVCILRIN EVVLEDEGEY MCEATNPSGR
AITKCFLHTT RFCLLLLKRP NLLASPNELN GETTLWRRSL SKKSISEETN SYVFFEAVPA
AEAVEVHAIL AENDLETPLS SIHDDSRTTV GTVDAFDISS ADSSIARHFS FYDEPSNVKI
SATFVDSPQR SDVSAKFRTV NDQNMQCIFD IVAYSINESF ELIYRYPTPN RSRYFNQKYS
TSSYETCLSL HLSRPNAFES AAIIALQKDV KKTLLAKLAV IDTAERTLSS RQSVNECCSI
ILALSAAGRT MKQEMTLSCA APGMFSNDHS EEFAHSSVEW NLTKQSPSDN DSLTVMSTVK
SPTIRAHASI NSKELDLWNE SFDNPFPEEA SLIDQERLLE PRTPLLPEKV TYRGQEIGLC
VREMDEPDIV ADKPKRELIE KYVEALFDFS YTVEDINGNG AAEMENSKNV DTSLVMPKIV
DRHADVHNTR LATAASEAVI TKLTETDSEK AYPHPRGNEQ SSMASDITSE ASNNGSLVKT
PEGTVITEED IDMFRCEDIS ELIMETIEEA EDSSQCEDVF EAYSADGNQF VEFFFQKPSQ
YGEATENRGI GFPSPSDMIE RGEANKEALI LTEQQLATKE AALESKTSKH YNYSEELNRA
KEAVKRTEAE LDEVRIRHRS ISLSEEAQMI ERAIYDISDR IMQQQPLTEA QAEANEELLR
ATLEEMIMDV NAKPSKNGSS LYKKPIALLR QKLANLEHSL IADEEVGVIM GNNEDKKTET
LKLEASSDPS RPSPAHYSLH NKKRMAKRMS SELARMTPLT NSIHEQLSTI ETMLDEVELD
EFEENLEGTS EDAKLLQSKP TTKRREMHGI LVQINHELNT MKRYCRKNIS RKGADAVVGV
LQKVRGNVSS IVSMVSRSKK KRRSRTKSPD KHTSKTGFFF GTEASINFNL FKSPAQENVD
IAVMYRSTSD GSTHQSLTDD HKTVSDSVRC QYGYKVPTGS DDNMPTPKSG QDIPINSGVL
PNQNTVGHPC DLCPEIIVLT PVDLAVPSPC VCQSMTNDDD VPVRPPRPRR SQSREAEEKR
LIEMLASQAS NLQETPTIAE LNVDEIAEIA RMRSELEQLE SHLDDNKKDL YGSDVISENE
TQELEIRRRT SVENVSSVFP LIPVRKAFFT TLDENSSVQL FCEESDYGNE SDTGSRTFHG
SAKVHPSYAL SAAVIPEQGE KYTAEECARA KEREIVLLAV QELANELDSN RTASISTSDA
SGKWSRKSNS TPYSDVEIDV VLEHNVESSG HESIECNQTA EESDQTSSFT DIYVKRDVVE
SCSLNDIESL LGRDESGDEA NDVRIMLTSA PIADMVNVMP TIMERSENSR TNSAMTASRS
SATTTTDSLL PRVINIDKIE SLQASGYVFA NPYIEGSDEE TIEHCESGFL PLPRGKSKER
SDERNIYRIS ESQMKTYGKC DKTEQNAENV PEEICIDVNL KRRPRKLKVL CTLAPEVLMN
VSALATMGES VEVVVEQPSE SQGYLVKITD DVSDSVHLSV IEVLPPVSID VEVSLSNDEQ
TDFEEVVAVQ PDRYRLLMKN LNDMNAFIYD GGETDLIDSM QRTGVSISIV ARSTRDAVYA
SLEEIPWGEV SMHICLSENE MVRSMSGSET RANSLIQNVT VSESNDHERK SLRSQESFKS
SQKSLAFSDR SERYDSMQSL NVPSYVLKEG STATITCELN NFLSPNSHID WYKGKAAVET
KPGKIDRISH DLLEVLVISH VELDDSDVYS IEVDEHVYPV AFLIVEEDDQ FEKADDVSKP
TFITPPQTLF VMEGQPAIIS CQLNGLHQNV VWCKERKVID GDNHRFKIES DDNGLHRLII
GESELDDQGT YYAYVDDRFT AITLVVEVSN PFPCSESARQ EQINERELTV TASGTESEED
DYREYVVPPG STATIACELE SDDLRELCWR KDGENIVFDD DSKVEHVVNG LKHYLVIHDT
QPNDSACYSV RINNAEFKVA HMIVSNCATS IAGDMAKEET LVPAGASAVI HCETITQEKS
LIWQKDRRPL SHDDRYEYSD SADGHEHSFT IHGVRKSDEG EYGVIISEAY TAVTNITVID
SDYQLMRGEE ATTTHYFSVP MKRPTFVSEA TMNSVEQRHF YDEYQVCDVN EYFDLHFRTQ
SYETPVVVRE SRSESVALSC SSRESSTGRM EEEIVEVEVK RHEWQKAAKD VTVLESHVLQ
TTCEMSLDST DYDVSIELAP FYGRVTMVEK VVTPTPRAFA SIQIAQRCID ADLFRTNVYG
MLSVESIRWM PRYESGVQMS VSSTRSETVE LGAIIGCGTE NEQISVVLLT SPPISHVSSV
ACSYAQTHLW TELCAEFVSV VNTEISRLIS NDTAVVARLD STTVEDIESV LRLHRDESKE
LLNAVVTTLP EPIFVHFSDN VAYTELSQWL NSTVIRGDYS EITRKLIRTC SEHIYLQESS
LEEQFSSVDC HQEYAQEMAE CILKPHLVPK TAEVSASFAN EQVVFSLDSA VVRQTGSNFV
AKMINTAKEW ICLQETTIED NYSDIFIECA TSYQDCFISL MSRPSPETVQ VVSEIALQKA
QYFFDWSVDE CVERRFIARV MRNAFISMQL RGITIEEGTF DVLIGRRWER EQLQVTVLVP
ARAAFENAKA GFAFEGVNYL MESFEVRSIE SDFVVKVSNT LCLSVSMCAS TTEEIVTHIE
KEQNNSAEHA LVTVIPRPPP HHAEVITDIA SQEFNNFFDS SLVQRIEQRT SVIIFRQAYT
SMQLHRTLLE EGDFGVWMGR ILEQDEAFVT VICRPPPINA RVSASIETQE TSYFFDSFVD
QQVEFKVISK VRRKAFTSMQ LHAETLEEGE FDVLMGRRWD REEVNITLIS HPPPVHASVQ
LTLEVQEASY FFDSFTDQRV ELNVRSKLVT RAFTSMQLHA VKLEEGIFDV FLIRTSNPVG
TSILLWHRPL PISAHVMSHI ELQEASYLFD SFVDETVECK VLSRVFTRAF TTMRLHATSI
EDGQFSVFMV RKTEEEEIFV SVAAPTTSSR TETRAGFACF QMSYLFDSEV ARGIRRYLRT
KGTHRAKASL SLCAAKSQRD EIRSFKEHSD FTHERMLTKS LVDFIADQDR SCNFSGERHL
QSEFERLGAT VTEGYDSSTV MLERTYQEST HVRISAEPSA QGISAAAYEY AHTQLRASAF
KEAEFHTSLN RRSESDELSV TVVSPLYSHA HHEMALSMVS KAIQEDEMQR TAIEEECGKI
VGEIASDEEV SVVEDSLSTS SQGIAFTKPQ FIQRLNEIYE LDEETSVTFK CIIGGVPSPS
VRWFLNNTRV IEDRNVSMIA EDGIYLLRTK CIDCTWNGTL VCEAINSFGC IRSSSRIVVK
GVQQIDIRTT ERVSETQSKV ISDLSSIPRK PSSPDLSTTS TTSSVGQAPE FQQPLAEKTT
VKIGEILQLK CVVSGSPLPT CQWTRNGVVV EQNSENTIIS EDGICILRIR SATLKDSAVF
RCTATNTSGT AQTESTVFVD DDLSHDSSVS EAPHFILPLK NLEPSSREHV QLKCIVSGSP
MPSVRWTLNG RTIEEGEKGF EMACEDGIVL LRMTEKVESG IFVCQAVNSV GQARTECRVQ
IKEPKTTSLE ATVMASNINF LVDADVFVIT KINYETKATI KMDEKPKKTD ADFKIIIIIE
ESIIRTRKCA KVIERRFKIV RTYGEGEEKV IASGQLGRSL EQVRRAIEAF LVEEKRKGIL
VEGENLERII EVLHVPKFNQ ATGEQEMEEF DHQPPESRSR LNTGTFTERM SGMTEQLIQR
KTYTIKRESV WESDEDELMI TDINCICAPP FESAEANIIV RSCVQYSASV NIVCRGHSPT
DATETFFEII TEGWVTRNIN HAYNEPAAPR FVRPFSVAKT FRNIYELRCT ISGYPSPSIR
ILHNGIPIRH NDRRYRIIYE CGIVILRMLQ IREGHYVCEA SNSSGKAITE CYLKGDEQLS
DIFEVTRVFD RHGFLLPSDR APTSYVALTG QDSVHRAFQY PALNFGVANS LDMQRFSKKE
MTFERLSRTP QRNEYRSDSQ YSTVKMSGDI EEPFLRTGIS RTWDQSYSDE HVSCTRKQES
KNETEERLPT ATDSRPKEGT ESSYATTDGT IFRGLTAEED DTSLMGKYGG TKEENGTEMI
PYETPNFPLP LTDIVTEPVD FIELRCIVIG HPEPKIRFIF NDHDLQSDLS AQIIHEDGVV
LLRKSGPDIE GHYICEATNQ IGTSKTECHV YFKQTVEDME RNKIEYFERK ETRERITRVS
EHCIDSTSES ETVSKYSQQQ RRNVQSRDLF PADSNQRAVQ FQVLGHAIQK SGSEGSSEGF
IEEKTYLKPC DETAALDLTF GQKTSADVVE VDMIIRATGR IYDDSNKTGT VKHELHIVEE
VCCEIKARKN EIAAVVEITV IDKIVAGIKK RICDGPHQQT DMDENVICDQ AETVEVTTPF
HTIPTEAAHL YISRPLSSSV TMQGTELDEM SQGFSSVAQR ISHMSRREYD NYLEDNALNM
SERDFEEFSR LIRMYMSQNE YERYLQLRRN LSTMRATYDA STAYSEGTIP HFVGQRVDSA
FVEKGRQLKE VALGRKTNER FGLSLAEEHS TSSSHYARLE ADRGAEVFEI VGERHEKASV
VAFFPTEKVS MRETGTFSTV GTAMSAQGET LRENVIFEVS KRLDHRDGTR AIEMRHLQIE
ESNKEICIEK DSSRATIQVC VTEGGFVETT RHLHAHVAME SEAIDVTLDK EQQVLFAEIA
IELNQQDAVW FALGRTMIAL KGEIQRSHTV LDIAREHVVH KIELIEKIMH PQMEDTNKEV
DMQKAPIMAK LDVQIIDSMI PCISLTIPRV IPSEEENFEA LISKETSKEV VMERTSSTAF
VDVTVLENVY AQSKRLVTTE TVKETEAAEV VVDKPYQQLS VAVNIADFQK EAVYFSWSRV
VEITKGEAVH EQLVIGAAEA RTVVEELVKE EVRREEIEET SKEVVMERTS STAFVDVTVL
ENVYAQSKRL VTRETVKETE AAEVVVDKPY
//
