ID A0A0M3K7R5_ANISI Unreviewed; 448 AA.
AC A0A0M3K7R5;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Epac (inferred by orthology to a D. melanogaster protein) {ECO:0000313|WBParaSite:ASIM_0001700601-mRNA-1};
GN ORFNames=ASIM_LOCUS16413 {ECO:0000313|EMBL:VDK57725.1};
OS Anisakis simplex (Herring worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Anisakidae; Anisakis;
OC Anisakis simplex complex.
OX NCBI_TaxID=6269 {ECO:0000313|Proteomes:UP000036680, ECO:0000313|WBParaSite:ASIM_0001700601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:ASIM_0001700601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDK57725.1, ECO:0000313|Proteomes:UP000267096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UYRR01033071; VDK57725.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M3K7R5; -.
DR WBParaSite; ASIM_0001700601-mRNA-1; ASIM_0001700601-mRNA-1; ASIM_0001700601.
DR Proteomes; UP000036680; Unplaced.
DR Proteomes; UP000267096; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.8.1240; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR043533; CNBD1/2.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23011:SF32; CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23011; UNCHARACTERIZED; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00135};
KW Reference proteome {ECO:0000313|Proteomes:UP000267096}.
FT DOMAIN 231..332
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 380..448
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
SQ SEQUENCE 448 AA; 50653 MW; 5641161BEF42D645 CRC64;
MHFSVGNPLA DRLRGCKKGY GGGRVVETIN SVALFGELSE QRHTCSARVT RTAEFVTINH
SHFIALYNSV ESRTIEAGLL LKRTMQLRAA GMIRDRKGHM QIYRWCMIGN EMVDWLCALC
VETLNSNTTS QISRFQVVVN NEVQFADKHI FYRWTLDEDS NEVGMRARNG YLAEVDNPIP
IVHLSDLASA VFFLSTIGPD ALFRMILSKP SSERSAEELE LVHEELLHVK ALAHLSTMVK
RELASVVLFE QHQHTGTILF RQGDEGSCWY IILKGSVNVS IHGKGVVCTL QEGDDFGKLA
LVNDAPRAAT IALNEDNSQF LRVDKTDFNR ILRDVEANTV RLKEHGHDVL VLEKINNTYK
QDSTAHDPYT GEPVTSRQHC CYSVMAGLPE KMVEYLLETR IDAHAEDGYV DTFLEDFVLT
HTIYMPPNIL CNYLKNYYMR GSTVCLPF
//
