ID A0A0M3K919_ANISI Unreviewed; 661 AA.
AC A0A0M3K919;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=DNA repair protein complementing XP-C cells (inferred by orthology to a human protein) {ECO:0000313|WBParaSite:ASIM_0001746101-mRNA-1};
OS Anisakis simplex (Herring worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Anisakidae; Anisakis;
OC Anisakis simplex complex.
OX NCBI_TaxID=6269 {ECO:0000313|Proteomes:UP000036680, ECO:0000313|WBParaSite:ASIM_0001746101-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:ASIM_0001746101-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
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DR WBParaSite; ASIM_0001746101-mRNA-1; ASIM_0001746101-mRNA-1; ASIM_0001746101.
DR Proteomes; UP000036680; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR PANTHER; PTHR12135:SF0; DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 374..427
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 429..484
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 491..565
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 171..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 661 AA; 76176 MW; D9A44C8FE42CA9B4 CRC64;
LRQEVNRQIL KRQINCHKMH LLCYVAHLRV WMRSLVRSEY LSAQCLSLIP EGYVQSAQLS
FDTASVERFM KWFHSAFVRK DLTIYLTRSG FCDAQVERLG MLISDKVYET PKDIASILVL
CLLALKQSVR LCLSCYPISH KPVSCPFLDV HLYYRSSVNF DDLKSLAKSN EKKENEASSS
KADSSKTSNR TGKESTKDNA TSAELNESAS EMDWTPKSKR QKEEEQKKRF KKAVNSSVKG
ITVNSKKKMP TKKVNLGRNY WVEYWDEISE EWICIDPIKG TIDMAELIES DATSPMHYVI
AIDNELSICI DSKYDCIEFG MRDVTARYAS KYLSSEVRRL RIDEEWWKSS LMPFQSKNHA
RNRLETVKLH NFLMTKPMPV TVAEFKNHPL YVLKRDLLKF EAIYPEDQKP VATFRGGIEV
YPRSSVYHLQ GALNWMKQAR SVKPGEKPYK VVKARPNIRL PEEQREPKTL DVFGYWQTEP
YVPPEIVDGR IPRNEFGNIY MYKECMLPKG CVHLHLDGLY GLARQMDIEC APAVVGWEFH
KGGSHPILDG CVVLAKDAMR LKAAWTEHYE KKRINAEKVY RVLSSQSDYT SIXRVHARFL
GPDRRHLSVD ECLENADESA ANEPKTETPI NDDMATAWPA TNFTLPTSKY RNNDDADEEV
L
//
