ID   A0A0M3KAC5_ANISI        Unreviewed;       501 AA.
AC   A0A0M3KAC5;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=RNA-dependent RNA polymerase {ECO:0000256|RuleBase:RU363098};
DE            EC=2.7.7.48 {ECO:0000256|RuleBase:RU363098};
GN   ORFNames=ASIM_LOCUS17323 {ECO:0000313|EMBL:VDK60112.1};
OS   Anisakis simplex (Herring worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Anisakidae; Anisakis;
OC   Anisakis simplex complex.
OX   NCBI_TaxID=6269 {ECO:0000313|Proteomes:UP000036680, ECO:0000313|WBParaSite:ASIM_0001792101-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:ASIM_0001792101-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDK60112.1, ECO:0000313|Proteomes:UP000267096}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517,
CC         ECO:0000256|RuleBase:RU363098};
CC   -!- SIMILARITY: Belongs to the RdRP family. {ECO:0000256|ARBA:ARBA00005762,
CC       ECO:0000256|RuleBase:RU363098}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; UYRR01033995; VDK60112.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0M3KAC5; -.
DR   WBParaSite; ASIM_0001792101-mRNA-1; ASIM_0001792101-mRNA-1; ASIM_0001792101.
DR   Proteomes; UP000036680; Unplaced.
DR   Proteomes; UP000267096; Unassembled WGS sequence.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProt.
DR   InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR   PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR   PANTHER; PTHR23079:SF59; RNA-DIRECTED RNA POLYMERASE; 1.
DR   Pfam; PF05183; RdRP; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU363098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000267096};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU363098};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW   ECO:0000256|RuleBase:RU363098};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363098}.
SQ   SEQUENCE   501 AA;  58243 MW;  C1737D2353F9A797 CRC64;
     MCRLYARIGL PLEFITIECI AAPVSRYVDP PVRVIGHDYR RERDLSSLSE AEINDQKQRL
     MTPIEPRVDK KWVDELKRRK CFGLEYFIAA LISRGAVVKD QILRSEERKD GFMRKILKNF
     DHDREVTLET LERLLNAIDE RRETPSLLAT FDSIKENLQS HPDDLTKIYE KEKQGDYRRV
     RKVVLTPTRM LLVVPELLMG NRVLRKFDGT GDKALRIQFR DDNGEALKLN QVGQTIINVT
     VHNTMRRGIY ISDRHFIYLA SSNSQMRDSG CYFFDEGEDG KQVEEIRNQL GIFNKSNIPK
     LMARIGQCFT QAKLRHKHYN QTFDIIGGRD TSGEPYTFSD GCGRISVKYA EDIASDLDLG
     NCVPSCFQIR FRGIKGVVSV DPWLSDRTEW SQKYSVPDNR EKYKRKNKLR VHFRPSQNKF
     HGSVEMYIEI VKYSSPTGVC LNRPFIAILD QVSAMQGYKL HCRMTDRICE LLDRQLMELA
     EALMLENRYV NIVLMKLLLF S
//