ID A0A0M3QUD8_DROBS Unreviewed; 1044 AA.
AC A0A0M3QUD8;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Trpl {ECO:0000313|EMBL:ALC40459.1};
GN ORFNames=Dbus_chr2Rg38 {ECO:0000313|EMBL:ALC40459.1};
OS Drosophila busckii (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC40459.1, ECO:0000313|Proteomes:UP000494163};
RN [1] {ECO:0000313|EMBL:ALC40459.1, ECO:0000313|Proteomes:UP000494163}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole larvae {ECO:0000313|EMBL:ALC40459.1};
RA Zhou Q., Bachtrog D.;
RT "Ancestral chromatin configuration constrains chromatin evolution on
RT differentiating sex chromosomes in Drosophila.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP012524; ALC40459.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M3QUD8; -.
DR STRING; 30019.A0A0M3QUD8; -.
DR OMA; CIGQVAV; -.
DR Proteomes; UP000494163; Chromosome 2r sequence.
DR GO; GO:0034703; C:cation channel complex; IEA:UniProt.
DR GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR PANTHER; PTHR10117:SF47; TRANSIENT-RECEPTOR-POTENTIAL-LIKE PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR SMART; SM00248; ANK; 2.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000494163};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 483..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 569..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 78..110
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 113..175
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
FT REGION 1008..1044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1044 AA; 119119 MW; 17F2D29404FDAD37 CRC64;
MDPLGRRALT LAIDNENLEM VELLVIMGVE TKDALLHAIN AEFVEAVELL LEHEELIFKE
GELYSWQKVD INTAMFPPDI TPLMLAAHKN NLEILRILLD RGAAVPVPHD MRCGCEECMR
LMSEDSLRHS LSRVNIYRAL CSPSLICLTS TDPILTAFQL SWELRNLALT EQECKADYIE
LRRQCQKFAC ALLDQTRSSN ELAIILNYDP ALSTYEPGDR MSLTRLVQAI SFKQKTFVAH
SNIQQLLSSI WYDGLPGFRR KSIVDKFICI AQVAMLFPLY CFIYMFAPNC QTGQLMRKPF
MKFLIHAASY VFFLFILILV SQRADDDFVR LFGTTRMKEN LAEQEQRQRG QTPSKLELLV
VLYVLGFMWE EVQEIFAVGL QSYLRNMWNF IDFLRNSLYV SVMCLRTYAY IQQATEIAKD
PQMAYIPREK WHDFDPQLIA EGLFAAANVF SALKLVHLFS INPHLGPLQI SLGRMVIDIV
KFFFIYTLVL FAFACGLNQL LWYFAALEKS KCYVLPGGEA DWASHGDSCM KWRRFGNLFE
SSQSLFWASF GMVGLDDFEL SGIKSYTRFW GLLMFGSYSV INVIVLLNLL IAMMSNSYAM
IDQHSDTEWK FARTKLWMSY FEDSSTLPPP FNVLPSVKWF IRIFRKSSKT IDRQRSKKRQ
EQEQYSKYDN IMRSLVWRYV AAMQRKFEHN PVTEDDINEV KNEISTMRYE MLEIFENSGM
DVSSANKKEK HQKPRRMKVW ERRLMKGYEV APVKTHSEPE LLSNVNGEGE MREVKIESVP
SRPAKETARE RFQRVARTVL LQSSTHKWNM VLQGTMSNSQ IGRSTKHERK QLHNLGKAIE
EARKLILLNP GCASGRESPI RIEFEDEKTS TLLDLLNQIS AEISSCERPR NKPCWRPPLK
SVPARALADD IEWYHSNTRS APELQTSTVS RSRELNLCPS KLVTSTAGSK KAAPLAPTPA
AKSAAATNKC KTTPFSVELA LATRRGNSSY GVPSGNSTSF DMQVVDLNER GQRGGGGGGV
AAADKDNISD VSSIVSMSPK RPKH
//
