ID A0A0M3QVJ7_DROBS Unreviewed; 820 AA.
AC A0A0M3QVJ7;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Cng {ECO:0000313|EMBL:ALC42513.1};
GN ORFNames=Dbus_chr2Rg2092 {ECO:0000313|EMBL:ALC42513.1};
OS Drosophila busckii (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC42513.1, ECO:0000313|Proteomes:UP000494163};
RN [1] {ECO:0000313|EMBL:ALC42513.1, ECO:0000313|Proteomes:UP000494163}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole larvae {ECO:0000313|EMBL:ALC42513.1};
RA Zhou Q., Bachtrog D.;
RT "Ancestral chromatin configuration constrains chromatin evolution on
RT differentiating sex chromosomes in Drosophila.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP012524; ALC42513.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M3QVJ7; -.
DR SMR; A0A0M3QVJ7; -.
DR STRING; 30019.A0A0M3QVJ7; -.
DR OMA; ECEPQTR; -.
DR Proteomes; UP000494163; Chromosome 2r sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:UniProt.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.5.300; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR032406; CLZ_dom.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR PANTHER; PTHR45638:SF11; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR Pfam; PF16526; CLZ; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000494163};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 265..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 586..692
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 119..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 735..773
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 125..142
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 820 AA; 92885 MW; E874765EFD195370 CRC64;
MMSSRRRNES ESPKYGYNLS SARSHPMYRT TRFVGASASA PPSCSNAAQQ QQQLEELEVT
GGLYAPFQPM PLSSEAVCLP RKHLIANQVA QNEELVEQHQ LHYPHGSWQR RQRIALQQQH
QRDFVDDDDD DDDDEEELTD EFAEMEAQRT EPRAQQAAIA PAESTESTAA AGAVNFMENG
SKLIQEPSKR SKPSALSRTL QALRQRLTKR SRAKPPDWFL EKFSNTTNTD KLGKSGADAA
LSSEIRGSSA LCNRLSVDPT LQSHYRWLAV VSLAVLYNII FVMGRSVFWE INKSAPGFWY
TLDYLCDFIY LLDTLVHMHE GFLDQGLLVR DAFRLRHHYF HTKGWYLDVL SMLPTDLAYI
WWPPETCSSL YLPCPVIVRL NRLLRLPRLM EWFDRTETAT GYPNAFRICK VVLAILVLIH
WNACMYFAIS YEIGFSSDSW VYNLNGTRNN TLQRQYIYSF YWSTLTLTTI GETPTPENDA
EYLFVVADFL AGVLIFATIV GNIGSMISNM NVARVEFQNR MDGVKQYMAF RRVGHELEAR
VIRWFAYTWS QSGALDEERV LAALPDKLKA EIAIQVHMDT LKQVRIFHDT EPGLLEALVL
KLKLQVFSPG DYICRKGDVG KEMYIVKRGK LSVVGDDGIT VLATLGAGSV FGEVSVLEIA
GNRTGNRRTA NVRSLGYSDL FCLAKRDLWE TLADYPEARS TLTQRGCQLL RKDGLLDEQI
FADSQRVHDS IEGGIEKLEL SVENLNMRLA RLLAEYTASQ AKIKQRLAKL ELNGTGTSRG
DELQTRPRSG RLYSLQTKRR PRARLEAAAK SGEAAKQNTL
//
