ID A0A0M3QVU7_DROBS Unreviewed; 715 AA.
AC A0A0M3QVU7;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Fit1 {ECO:0000313|EMBL:ALC43023.1};
GN ORFNames=Dbus_chr3Lg189 {ECO:0000313|EMBL:ALC43023.1};
OS Drosophila busckii (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC43023.1, ECO:0000313|Proteomes:UP000494163};
RN [1] {ECO:0000313|EMBL:ALC43023.1, ECO:0000313|Proteomes:UP000494163}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole larvae {ECO:0000313|EMBL:ALC43023.1};
RA Zhou Q., Bachtrog D.;
RT "Ancestral chromatin configuration constrains chromatin evolution on
RT differentiating sex chromosomes in Drosophila.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the kindlin family.
CC {ECO:0000256|ARBA:ARBA00008052}.
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DR EMBL; CP012525; ALC43023.1; -; Genomic_DNA.
DR RefSeq; XP_017843312.1; XM_017987823.1.
DR AlphaFoldDB; A0A0M3QVU7; -.
DR SMR; A0A0M3QVU7; -.
DR STRING; 30019.A0A0M3QVU7; -.
DR GeneID; 108600321; -.
DR OMA; PEHGIHY; -.
DR OrthoDB; 5399911at2759; -.
DR Proteomes; UP000494163; Chromosome 3l sequence.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13205; FERM_C_fermitin; 1.
DR CDD; cd17095; FERM_F0_kindlins; 1.
DR CDD; cd17096; FERM_F1_kindlins; 1.
DR CDD; cd01237; PH_fermitin; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR037843; Kindlin/fermitin.
DR InterPro; IPR040790; Kindlin_2_N.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037837; PH_Kindlin/fermitin.
DR PANTHER; PTHR16160; FERMITIN 2-RELATED; 1.
DR PANTHER; PTHR16160:SF13; FERMITIN 2-RELATED; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF18124; Kindlin_2_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000494163}.
FT DOMAIN 406..514
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 359..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 715 AA; 81216 MW; FF6440A295C89FAB CRC64;
MIHVGENTWN LRILITDLQV EKTLRVRGDQ HIGGVMLQLV DPEMPKDWSD HALWWPAKNT
WLTRTRSTLD QAGVQADSFL HFTPMHKTLR VQLPDLRYLD YRVNFSIKTF GAVVHLCKDL
DIRYPEELSL CKPIEQEHLK KNFSKVPQKM IPVAEANGTT YLQPAADTNS FVPISNAYHS
NGSLDRTQGN GNGLLCAPAS PYGTTPRRAA TAPGTPISSP TGTWKHNSSN GYGYGYDSNS
SFGDFQENLA VSPRSPSADV RARLLRPKSL VQKARLNVGW LDSSLSIMEQ GVREYDTLCL
RFKYFTFFDL NPKYDQVRIN QLYEQAKWAI LNEELDCTEE ETLMFAGLQF QVNYQTDMQP
AGLDSSPSKN SHENGADDDI DSALNELQIT LEGPGGGNDS GNITRIPELS DYLRFLKPQL
FTLKGFKRYY FTYKDLHLHL FKSQEDSRRA APSISINLRG CEVTPDVQLA QGKFGIRLEV
PPQGRNGPNS EFWVRCENME QYAKWMAACR LAAKGRSLAD SSYESEVQSI RSLLQIQKPQ
AQAAPLNINP RSVDAQDYLS VKMQRKLASK AVQRILEAHA NVRQLALMEA KLKYIQAWQS
LPDFGVTLFV IKFDGHKKEE LLGVAHNRIM RMDLNTGDHI KTWRYNTMKA WNVNWGIKCM
MIQFHDENVV FSCLSADCKV VHEFIGGYIF MSMRSKENNQ TLNEEMFHKL TGGWS
//
