ID A0A0M3QWI9_DROBS Unreviewed; 923 AA.
AC A0A0M3QWI9;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=CG14168 {ECO:0000313|EMBL:ALC44229.1};
GN ORFNames=Dbus_chr3Lg1395 {ECO:0000313|EMBL:ALC44229.1};
OS Drosophila busckii (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC44229.1, ECO:0000313|Proteomes:UP000494163};
RN [1] {ECO:0000313|EMBL:ALC44229.1, ECO:0000313|Proteomes:UP000494163}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole larvae {ECO:0000313|EMBL:ALC44229.1};
RA Zhou Q., Bachtrog D.;
RT "Ancestral chromatin configuration constrains chromatin evolution on
RT differentiating sex chromosomes in Drosophila.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR EMBL; CP012525; ALC44229.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M3QWI9; -.
DR STRING; 30019.A0A0M3QWI9; -.
DR Proteomes; UP000494163; Chromosome 3l sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR24214; PDZ AND LIM DOMAIN PROTEIN ZASP; 1.
DR PANTHER; PTHR24214:SF59; Z BAND ALTERNATIVELY SPLICED PDZ-MOTIF PROTEIN 67, ISOFORM G; 1.
DR Pfam; PF00049; Insulin; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR SMART; SM00078; IlGF; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Reference proteome {ECO:0000313|Proteomes:UP000494163};
KW Secreted {ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 81..133
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 361..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..417
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..468
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..488
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..585
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 923 AA; 102327 MW; 1DA0F20A10F276B8 CRC64;
MVIDIKMCRF DNVPWGFRLV GGADYEYPLT VVKVRHVLYN ACSPNNNNNN NNSKCHTCML
FAYLCHVTTT KATTVALAAC VAEGSIAEEA GLRVEDVIVR INDTAATPLT HDEAHRLILS
SGSVFYFGVY RENEEDAYEC PKRFPLSSSS LTKSPTPLAS PGYDSLSPVP SLTEATKAHI
PEQVVAASQA AVTTAVAQAE SEVAALQDAL ECRSAMAEVH SADYNDNNNN NNNNGNNCNN
AMDTMDSLYL PDLPDRPCSA LSEQTEIKLV EEEIAAVLSG ESEVLKEHQV LGVNFYRIFP
KPGVCMTSDV LRSLNEEVTK TKLEKEKENR KWSTFLQRPD RPVPKSKQQL EAERRAANAY
KVKIVKSQPR EKSPMPELKP AAKEATPTPA EEESKPPTNE QENKQETEAH VQTEEEKEQE
ELEQEPLPTD SEVPNLEQLP DNGSNNNNND DYDDKPELPE DNGEQGESSD AEQLEKADAS
KDEQSDGQEQ QEAESEATTP AKTDEELALE KQLADVQKQL AALSSLPSTI QSTLDAVTKQ
LAELLPTFKL QQQQEQQQGE GEGQKQLPEI DEQQAEEDKL AGGEHEGAGM RIMSADSGGV
CPGVSADDMP QSACENNEDK CDDANDLEVS KISLSNGGDN CALEEQQQQE LNEQQSFKKQ
KKHNVIEELE EHLVRKNNPK RSKRAFGPLT PSSERPLVLP GGRRWYRPKD AYNDEFIAET
LSAQAELITG STLGVNFMKY QKPERKIDLN RSEVYKVIHH LDRAPVRGIE RAISTVLLSV
EFQLFQAVTS SMFNKFSVTL AMLLALCALS SSREVNMRLC SDMLNQALSK MCEKTGFNDM
VSKRSSYAAL GFDPIDPIQF IEAKESADVL PYPLSNGRMS DFYDNNVISS LTATRRLTRN
GIIEHCCMRA CSKYELSGYC RAP
//
