ID A0A0M3RDQ6_9BACI Unreviewed; 601 AA.
AC A0A0M3RDQ6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=B12-binding domain/radical SAM domain protein {ECO:0000313|EMBL:ALC88782.1};
GN ORFNames=AM500_02435 {ECO:0000313|EMBL:ALC88782.1};
OS Bacillus sp. FJAT-18017.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=1705566 {ECO:0000313|EMBL:ALC88782.1, ECO:0000313|Proteomes:UP000060713};
RN [1] {ECO:0000313|EMBL:ALC88782.1, ECO:0000313|Proteomes:UP000060713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FJAT-18017 {ECO:0000313|EMBL:ALC88782.1,
RC ECO:0000313|Proteomes:UP000060713};
RA Liu B., Wang J., Zhu Y., Liu G., Chen Q., Chen Z., Lan J., Che J., Ge C.,
RA Shi H., Pan Z., Liu X.;
RT "Genome sequencing project for genomic taxonomy and phylogenomics of
RT Bacillus-like bacteria.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP012602; ALC88782.1; -; Genomic_DNA.
DR RefSeq; WP_053597774.1; NZ_CP012602.1.
DR AlphaFoldDB; A0A0M3RDQ6; -.
DR STRING; 1705566.AM500_02435; -.
DR PATRIC; fig|1705566.3.peg.499; -.
DR Proteomes; UP000060713; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR026447; B12_SAM_Ta0216.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR007197; rSAM.
DR NCBIfam; TIGR04190; B12_SAM_Ta0216; 1.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF1; TIGR04190 FAMILY B12-BINDING DOMAIN_RADICAL SAM DOMAIN PROTEIN; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00326; 5''-pyrrole_methytransferase; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000060713};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 26..162
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 218..461
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 601 AA; 69746 MW; 374D9517E27CED60 CRC64;
MVYDLVLLHP PTVYDFRKEM LFTGPISDVV PSSPVFEMYP IRLTSIGDYL ERYGLKVKII
NIANRMLMNP HFDVEKKLRE IKTKAFGIDL HWLPHAHGSI ELAKICKKHH PTVPVMFGGL
SSTYFYKELL EYPCVDFVVR GDTTEKLILM LLNALEAGNR DLSTIPNLSW KNDGEHIHNP
HTYVPDSLND FNLPGYKYVI RSVFKYFNLL DPLPYKGWLQ YPNTAILTSK GCNYNCLICG
GSKDAYALNC NRKKILMRSP KNMLDDIALI QRFSRAPIFL LNDIREGGKE YVNEFFEGLS
KMKLKDELVF ELFQYVDEEF FEKLHKAVPK YSIEITLESS DEEIRRVNGK FNCTNKKVIE
TLQYALKHGC AKIDLFFMTG IPGQSYQSAI DNVDFCEKIH NECSNDPRLS YFIAPLAPFL
DPGSPAYEHP DLHGYKKFCF RLEDFRQAML SPSWKYMLSY ETNAMTRDDI VRATYDSALL
LNKFKLKYGL IKQDEYEEIE YKIVKSVEFM KRIDDLLLLP DKEKQAGLAL IKKEVEEVNR
HSICGKNELK WEVSKRYADF FTLGRIGLEL LGDEILRGIR CKLGRIDRKN VTVYSGEERD
Y
//
