ID   A0A0M3REF9_9BACI        Unreviewed;       725 AA.
AC   A0A0M3REF9;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=methylmalonyl-CoA mutase {ECO:0000256|ARBA:ARBA00012398};
DE            EC=5.4.99.2 {ECO:0000256|ARBA:ARBA00012398};
GN   ORFNames=AM500_09650 {ECO:0000313|EMBL:ALC90012.1};
OS   Bacillus sp. FJAT-18017.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=1705566 {ECO:0000313|EMBL:ALC90012.1, ECO:0000313|Proteomes:UP000060713};
RN   [1] {ECO:0000313|EMBL:ALC90012.1, ECO:0000313|Proteomes:UP000060713}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FJAT-18017 {ECO:0000313|EMBL:ALC90012.1,
RC   ECO:0000313|Proteomes:UP000060713};
RA   Liu B., Wang J., Zhu Y., Liu G., Chen Q., Chen Z., Lan J., Che J., Ge C.,
RA   Shi H., Pan Z., Liu X.;
RT   "Genome sequencing project for genomic taxonomy and phylogenomics of
RT   Bacillus-like bacteria.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408;
CC         Evidence={ECO:0000256|ARBA:ARBA00001922};
CC   -!- SIMILARITY: Belongs to the methylmalonyl-CoA mutase family.
CC       {ECO:0000256|ARBA:ARBA00008465}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP012602; ALC90012.1; -; Genomic_DNA.
DR   RefSeq; WP_053599016.1; NZ_CP012602.1.
DR   AlphaFoldDB; A0A0M3REF9; -.
DR   STRING; 1705566.AM500_09650; -.
DR   PATRIC; fig|1705566.3.peg.2078; -.
DR   Proteomes; UP000060713; Chromosome.
DR   GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004494; F:methylmalonyl-CoA mutase activity; IEA:UniProtKB-EC.
DR   CDD; cd02071; MM_CoA_mut_B12_BD; 1.
DR   CDD; cd03679; MM_CoA_mutase_alpha_like; 1.
DR   Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR   Gene3D; 3.20.20.240; Methylmalonyl-CoA mutase; 1.
DR   InterPro; IPR006159; Acid_CoA_mut_C.
DR   InterPro; IPR016176; Cbl-dep_enz_cat.
DR   InterPro; IPR006158; Cobalamin-bd.
DR   InterPro; IPR036724; Cobalamin-bd_sf.
DR   InterPro; IPR006099; MeMalonylCoA_mutase_a/b_cat.
DR   InterPro; IPR006098; MMCoA_mutase_a_cat.
DR   NCBIfam; TIGR00640; acid_CoA_mut_C; 1.
DR   NCBIfam; TIGR00641; acid_CoA_mut_N; 1.
DR   PANTHER; PTHR48101:SF4; METHYLMALONYL-COA MUTASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR48101; METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED; 1.
DR   Pfam; PF02310; B12-binding; 1.
DR   Pfam; PF01642; MM_CoA_mutase; 1.
DR   SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR   SUPFAM; SSF51703; Cobalamin (vitamin B12)-dependent enzymes; 1.
DR   PROSITE; PS51332; B12_BINDING; 1.
DR   PROSITE; PS00544; METMALONYL_COA_MUTASE; 1.
PE   3: Inferred from homology;
KW   Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW   Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:ALC90012.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000060713}.
FT   DOMAIN          591..723
FT                   /note="B12-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51332"
SQ   SEQUENCE   725 AA;  80251 MW;  61F73230D1158271 CRC64;
     MRNKPDFQTI SLFKKEQHEH VAIKSEPLLK ENNNFLFETN EGIALKSVYN EADLNGLEHL
     DDKPGLPPFT RGPYPTMYVN RPWTVRQYAG FSTAEESNAF YRRNLAMGQK GLSVAFDLAT
     HRGYDSDHER VVGDVGKAGV AIDSILDMKT LFNGIPLDQM SVSMTMNGAV LPVLAFYIVT
     AEEQGVTKDK LSGTIQNDIL KEYMVRNTYI YPPEMSMRII ADIFAYTSQF MPKFNSISIS
     GYHMQEAGAP ADIELAYTLA DGLEYVRTGL KAGIEIDSFA PRLSFFWGIG MNYFMEVAKM
     RAARFIWAKM MKNFNPKSEK SLALRTHSQT SGWSLTEQDP FNNVMRTLIE AHAAAMGHTQ
     SLHTNALDEA IALPTDFSAR IARNTQLFLQ EETGITKVID PWAGSYYVEA LTNDLIKRAT
     AHIDEIEQLG GMAKAIETGL PKMKIEEAAA RRQALIDSGK EIIVGVNKYK ANEEEPLDIL
     DIDNTAVRHR QIEKLNELKA NRDSQAVAEA LAQLEEAAKS GKGNLLEFAV EAARARATLG
     EISEAVEKAA GRHKASIRSI SGVYSSTFSK EEEIELVQQM AEEFLENEGR RPRILIAKMG
     QDGHDRGAKV ISTAFADLGF DVDIGPLFQT PAETAMQAVE NDVHVVGFSS LAAGHKTLLP
     ELVKELRKLG RPDILVVVGG VIPSKDYQFL YENGASAIFG PGTVIPVAAQ DIIKQIYKSL
     GYEEV
//