ID A0A0M3UAW6_9PSEU Unreviewed; 322 AA.
AC A0A0M3UAW6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=UDP-glucose 4-epimerase {ECO:0000256|ARBA:ARBA00018569};
DE EC=5.1.3.2 {ECO:0000256|ARBA:ARBA00013189};
DE AltName: Full=Galactowaldenase {ECO:0000256|ARBA:ARBA00033067};
DE AltName: Full=UDP-galactose 4-epimerase {ECO:0000256|ARBA:ARBA00031367};
GN ORFNames=XF36_08575 {ECO:0000313|EMBL:ALE83205.1};
OS Pseudonocardia sp. HH130629-09.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Pseudonocardia.
OX NCBI_TaxID=1641402 {ECO:0000313|EMBL:ALE83205.1, ECO:0000313|Proteomes:UP000062082};
RN [1] {ECO:0000313|EMBL:ALE83205.1, ECO:0000313|Proteomes:UP000062082}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HH130629-09 {ECO:0000313|EMBL:ALE83205.1,
RC ECO:0000313|Proteomes:UP000062082};
RX PubMed=26438860; DOI=10.1073/pnas.1515348112;
RA Sit C.S., Van Arnam E.B., Ramadhar T.R.;
RT "Variable genetic architectures produce virtually identical molecules in
RT bacterial symbionts of fungus-growing ants.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:13150-13154(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC EC=5.1.3.2; Evidence={ECO:0000256|ARBA:ARBA00000083};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. {ECO:0000256|ARBA:ARBA00007637}.
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DR EMBL; CP011868; ALE83205.1; -; Genomic_DNA.
DR RefSeq; WP_020623755.1; NZ_CP011868.1.
DR AlphaFoldDB; A0A0M3UAW6; -.
DR KEGG; pseh:XF36_08575; -.
DR PATRIC; fig|1641402.3.peg.1834; -.
DR OrthoDB; 9801785at2; -.
DR UniPathway; UPA00214; -.
DR Proteomes; UP000062082; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05247; UDP_G4E_1_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR005886; UDP_G4E.
DR NCBIfam; TIGR01179; galE; 1.
DR PANTHER; PTHR43725; UDP-GLUCOSE 4-EPIMERASE; 1.
DR PANTHER; PTHR43725:SF51; UDP-GLUCOSE 4-EPIMERASE; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023144};
KW Galactose metabolism {ECO:0000256|ARBA:ARBA00023144};
KW Reference proteome {ECO:0000313|Proteomes:UP000062082}.
FT DOMAIN 4..251
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 322 AA; 34026 MW; 1111C3E31680DCE4 CRC64;
MKLLVTGGAG YVGSVCAAHL LDAGHEVVVL DDLSTGHRDA VPAGAEFVEG ELGARAGEVL
GRGGFDGVLH YAARSLVGES VEQPEKYWDG NVVASFRLLE AVREHAVPRL VFSSTAATYG
EPEQVPIPET APTRPTNPYG ASKLAIDHMI TSYARAHGLA ATSLRYFNVA GAHLSGDTPL
GERHAVETHL IPLVLQVAAG TRESISVYGD DWPTPDGSCV RDYIHVDDLA EAHLLALTHA
VAGRHDIYNL GSGQGFSVLE VVQACRTVTG HPIPAVVAPR RAGDPAVLVA SSEQAAQQLG
WKPSRTAIAE IVADAWEFAR SR
//
