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Entry: A0A0M3UB71_9PSEU
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ID   A0A0M3UB71_9PSEU        Unreviewed;       468 AA.
AC   A0A0M3UB71;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   25-OCT-2017, entry version 14.
DE   SubName: Full=Malate dehydrogenase {ECO:0000313|EMBL:ALE83735.1};
GN   ORFNames=XF36_11735 {ECO:0000313|EMBL:ALE83735.1};
OS   Pseudonocardia sp. HH130629-09.
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Pseudonocardia.
OX   NCBI_TaxID=1641402 {ECO:0000313|EMBL:ALE83735.1, ECO:0000313|Proteomes:UP000062082};
RN   [1] {ECO:0000313|EMBL:ALE83735.1, ECO:0000313|Proteomes:UP000062082}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HH130629-09 {ECO:0000313|EMBL:ALE83735.1,
RC   ECO:0000313|Proteomes:UP000062082};
RX   PubMed=26438860; DOI=10.1073/pnas.1515348112;
RA   Sit C.S., Van Arnam E.B., Ramadhar T.R.;
RT   "Variable genetic architectures produce virtually identical molecules
RT   in bacterial symbionts of fungus-growing ants.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:13150-13154(2015).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Note=Divalent metal cations. Prefers magnesium or manganese.
CC       {ECO:0000256|PIRSR:PIRSR000106-3};
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DR   EMBL; CP011868; ALE83735.1; -; Genomic_DNA.
DR   RefSeq; WP_060714622.1; NZ_CP011868.1.
DR   EnsemblBacteria; ALE83735; ALE83735; XF36_11735.
DR   KEGG; pseh:XF36_11735; -.
DR   PATRIC; fig|1641402.3.peg.2509; -.
DR   KO; K00027; -.
DR   Proteomes; UP000062082; Chromosome.
DR   GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   Gene3D; 3.40.50.10380; -; 1.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR001891; Malic_OxRdtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   PIRSF; PIRSF000106; ME; 1.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000062082};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000106-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000062082}.
FT   DOMAIN       92    225       malic. {ECO:0000259|SMART:SM01274}.
FT   DOMAIN      237    457       Malic_M. {ECO:0000259|SMART:SM00919}.
FT   ACT_SITE    113    113       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   ACT_SITE    168    168       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   METAL       210    210       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       211    211       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       236    236       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
SQ   SEQUENCE   468 AA;  49107 MW;  70E2AD049C03EC37 CRC64;
     MSIPGPGYAI TARVDAPAHP TSAGDLTAAV GQVGGVVTAF DVVEARTESL VVDISVNARN
     TEHVEEIKAA IEQLEGFSVR KVSDRTFLLH LGGKIEVRSK VNLRTRDDLS RAYTPGVARV
     SMAIAENPSD ARRLTIKRNT VAVVTDGSAV LGLGNIGAAA AMPVMEGKAA LFKQFANVDA
     WPVCLDTQDT EEIIRTVQLI APGYGGINLE DIAAPRCFEI ERRLRELLDI PVFHDDQHGT
     AVVVLGALRN ALRVVGKKFS DVSVVVCGVG AAGSAIIRLL GSEETADVVA VDVDGIVHTG
     REGMDDNLAS IAAQTNKDGK QGTLADALVG ADVFIGVSAP NLFGETELRS MNDDAIVFAL
     ANPDPEVDPT LAMRHAAVVA TGRSDYPNQI NNVLAFPGVF RGLLDAQAHD ITDEMMLAAS
     AAIADVVAEP NPSFIVPSVF DQSVAPAVAE ALRNAATKQA KRGEVEAG
//
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