ID A0A0M4E532_DROBS Unreviewed; 645 AA.
AC A0A0M4E532;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=CG8399 {ECO:0000313|EMBL:ALC41304.1};
GN ORFNames=Dbus_chr2Rg883 {ECO:0000313|EMBL:ALC41304.1};
OS Drosophila busckii (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC41304.1, ECO:0000313|Proteomes:UP000494163};
RN [1] {ECO:0000313|EMBL:ALC41304.1, ECO:0000313|Proteomes:UP000494163}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole larvae {ECO:0000313|EMBL:ALC41304.1};
RA Zhou Q., Bachtrog D.;
RT "Ancestral chromatin configuration constrains chromatin evolution on
RT differentiating sex chromosomes in Drosophila.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|ARBA:ARBA00001970};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FRRS1 family.
CC {ECO:0000256|ARBA:ARBA00009195}.
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DR EMBL; CP012524; ALC41304.1; -; Genomic_DNA.
DR RefSeq; XP_017839910.1; XM_017984421.1.
DR AlphaFoldDB; A0A0M4E532; -.
DR STRING; 30019.A0A0M4E532; -.
DR GeneID; 108597726; -.
DR OMA; PLTMRSW; -.
DR OrthoDB; 3027001at2759; -.
DR Proteomes; UP000494163; Chromosome 2r sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08760; Cyt_b561_FRRS1_like; 1.
DR CDD; cd09628; DOMON_SDR_2_like; 1.
DR CDD; cd08544; Reeler; 1.
DR Gene3D; 1.20.120.1770; -; 1.
DR Gene3D; 2.60.40.4060; Reeler domain; 1.
DR InterPro; IPR006593; Cyt_b561/ferric_Rdtase_TM.
DR InterPro; IPR005018; DOMON_domain.
DR InterPro; IPR002861; Reeler_dom.
DR InterPro; IPR042307; Reeler_sf.
DR PANTHER; PTHR45828; CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE; 1.
DR PANTHER; PTHR45828:SF38; FERRIC-CHELATE REDUCTASE 1 HOMOLOG-RELATED; 1.
DR Pfam; PF03351; DOMON; 1.
DR Pfam; PF02014; Reeler; 1.
DR SMART; SM00665; B561; 1.
DR PROSITE; PS50939; CYTOCHROME_B561; 1.
DR PROSITE; PS50836; DOMON; 1.
DR PROSITE; PS51019; REELIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000494163};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..645
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005792837"
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 512..533
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 617..640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..193
FT /note="Reelin"
FT /evidence="ECO:0000259|PROSITE:PS51019"
FT DOMAIN 248..368
FT /note="DOMON"
FT /evidence="ECO:0000259|PROSITE:PS50836"
FT DOMAIN 372..570
FT /note="Cytochrome b561"
FT /evidence="ECO:0000259|PROSITE:PS50939"
SQ SEQUENCE 645 AA; 69981 MW; 34135B286FC2D149 CRC64;
MSKSLSSSHG VHWPVALVAL LIAIVATVHS LPQGAPETVC DTMLPFHAGG SVLPETSVCP
FAIETSASVV GQGQTLRVDV SGVPAGLSFG GFMIQARNRN PPYQIIGQFG PTRDGTVKLM
NCENSVNNSA THSNAGPKPQ VTLDWQSPVD FVGQVVFNAT VAQSYNQFWV GVPSNPVQVV
RRDVSAASLP TTPNNFNTNF GSTRAPYVPP NYVAPTVAAA GADPFYDGCG QTKNCFGLPN
GCVASKSCTA VAAVTVRGDI YEFELQSSKG TGAAYVALGL SDDAKMGEDL TTECVPENGR
VNLYSSYTSA SPYGANRANV PQNSARLLNA SMVDGVIYCK VQREPMTVVQ GRSFDLRNGV
YHMLVASGSS LKENSVGYHD IGRLPSANPI NLAVVQDLGG SSMLLVRLHG AFMIAAWIGT
TSLGIIFARY FKQTWVGSQT CGKDQWFAWH RMLMVTTWTL TIVAYILIWV ELKRAVWHAH
SIIGLITVIL CFIQPIGALF RPGPNDKKRP YFNWGHWLGG NLAHILAIVA IFFSVKLPKA
ELPEWMDWIL VGFVVFHVLV HLIFSIASIA SDRQQSQRIN TFQMGDMAHH HQHAMRNGMS
MERKMDAPYG GLRKGLLGVY TVVLLLFVVV LILLVVLAPI EKLFN
//
