ID A0A0M4EAH9_DROBS Unreviewed; 840 AA.
AC A0A0M4EAH9;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Hr39 {ECO:0000313|EMBL:ALC40365.1};
GN ORFNames=Dbus_chr2Lg2450 {ECO:0000313|EMBL:ALC40365.1};
OS Drosophila busckii (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC40365.1, ECO:0000313|Proteomes:UP000494163};
RN [1] {ECO:0000313|EMBL:ALC40365.1, ECO:0000313|Proteomes:UP000494163}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole larvae {ECO:0000313|EMBL:ALC40365.1};
RA Zhou Q., Bachtrog D.;
RT "Ancestral chromatin configuration constrains chromatin evolution on
RT differentiating sex chromosomes in Drosophila.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CP012523; ALC40365.1; -; Genomic_DNA.
DR RefSeq; XP_017835098.1; XM_017979609.1.
DR AlphaFoldDB; A0A0M4EAH9; -.
DR STRING; 30019.A0A0M4EAH9; -.
DR OMA; HSVLYPP; -.
DR OrthoDB; 3108057at2759; -.
DR Proteomes; UP000494163; Chromosome 2l sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd07167; NR_DBD_Lrh-1_like; 1.
DR CDD; cd06930; NR_LBD_F2; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR016355; NR5-like.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24086:SF25; NUCLEAR HORMONE RECEPTOR FTZ-F1 BETA; 1.
DR PANTHER; PTHR24086; NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000494163};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 393..468
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 613..840
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 840 AA; 91125 MW; 2CC29F686A7EA2B2 CRC64;
MSSIKTEQSA AAGGANSIGY QLPMNMSTAT AATTTTMGAS VASTVRHNVS VTNIKCELDE
LPTPNGNLVP VIASYNNHNH NHNHGNSLRI PLSGTSTGQA EEESDSEAEL ANIESLKVRR
RAADKNGPRP MSWEGELSEP ETNLGDEELM ETETVIKSEA SSSTSSSQVV AMMQPIKTEL
EHIAGEMQQQ QPQQQHQQQQ QLLPLKQNFG NKLKLAPTQS DPINLKYEPA VASSTLCERS
KSSSGGHLPL LPANPSPDSA IHSVYTHSSP SQSPLTSRHA PYTPSLSRNN SDASHSSCYS
YSSEFSPTHS PIQARHAPYP GTVPTGAAAS YANGATPLHH HSLLYRPLNV DAAAAAAAAG
QEAQNLSMDA SNLDATAALP ASPAGISRQQ LINSPCPICG DKISGFHYGI FSCESCKGFF
KRTVQNRKNY VCVRGGPCQV SISTRKKCPA CRFEKCLQKG MKLEAIREDR TRGGRSTYQC
SYTLPNAMLS PLLSPDQAAA AAAAAAAQQQ QHQQQQQQQQ HQQQQQQQQR LQHQQQLNGF
NSGGGGGGSS CGSLPASPSL GAAIKTEQTE AQLLTRASSV PALLQEIMDV EHLWQYTDAE
LARINQPLSS FGANGASNSS SSSEPQMTNP LLASAGLSSN GENANPDLIA HLCNVADHRL
YKIVKWCKSL PLFKNISIDD QICLLINSWC ELLLFSCCFR SIDTPGEIKM SQGRKITLAQ
AKTNGLQACI ERMLNLTDHL RRLRVDRYEY VAMKVIVLLQ SDTTELHEAV KVRECQEKAL
QSLQAYTLAH YPDTPSKFGE LLLRIPDLQR TCQLGKEMLT IKTRDGADFN LLMELLRGEH
//
