ID A0A0M4ECX7_DROBS Unreviewed; 1576 AA.
AC A0A0M4ECX7;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Sos {ECO:0000313|EMBL:ALC39547.1};
GN ORFNames=Dbus_chr2Lg1632 {ECO:0000313|EMBL:ALC39547.1};
OS Drosophila busckii (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC39547.1, ECO:0000313|Proteomes:UP000494163};
RN [1] {ECO:0000313|EMBL:ALC39547.1, ECO:0000313|Proteomes:UP000494163}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole larvae {ECO:0000313|EMBL:ALC39547.1};
RA Zhou Q., Bachtrog D.;
RT "Ancestral chromatin configuration constrains chromatin evolution on
RT differentiating sex chromosomes in Drosophila.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP012523; ALC39547.1; -; Genomic_DNA.
DR RefSeq; XP_017855031.1; XM_017999542.1.
DR SMR; A0A0M4ECX7; -.
DR STRING; 30019.A0A0M4ECX7; -.
DR OMA; KNTHRED; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000494163; Chromosome 2l sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF373; PROTEIN SON OF SEVENLESS; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000494163}.
FT DOMAIN 217..403
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 449..557
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 606..773
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 808..1045
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1057..1090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1224..1249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1306..1359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1394..1416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1430..1576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1069..1090
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1226..1249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1313..1327
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1342..1356
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1430..1505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1509..1525
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1554..1576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1576 AA; 178379 MW; 993D5458002A860E CRC64;
MFSSSGSGSH GISVASTVQD TDGYDFTKYE NAQRWKGLFI PSLRKVLEQV NPRVTANDEA
LAYVENLCVR LLALLCAKPL PHSVQDLEEK VKSFPSPIDQ WALKEANEVI NSKKRKTVLP
TERVHSLLQK DVLQYKIDSS VTAYLVAILE CISADTLKMA ADYVGRISHC EIAKEDIEVV
MIGDGVLLDM LNQSGDQHKS NVLPSPLSLP AQRASATYEE TVKELINDEK QYQRDLHMII
RVFREELVKI TRDPKELEPI FSNIMDIYEV TVTLLGSLED VIEMSQEQNA PCVASCFEEL
AEAEEFDVYK KYAHDVTSQA SRDALSNLLA KPNALSLMSA GHGFREAVKY YLPKLLLVPI
CHAFVYFDYI KHLMDLSTSQ DDFESFEQVQ GLLHPLHCDL EKVMANLSKD RLVPVSGRVR
RQMAIERTRE LQLKVEHWDD KDVGLNCNEF IREDSLTKLG SGKRIWSERK VFLFDGLMVL
CKPNTKKQTP SAGANAYDYR QKEKFFMRRV KINDRADTEE VKHSFELATP NYPATVLSAK
TAQHKNDWMA DLIMVNTKSM LDRILDSILQ DIERKHPLRM PSPEIYKFSV PDSPENIVLE
ERDSGVVPMI KGATLCKLIE RLTYHIYADP TFVRTFLTTY RYFCSPQQLL TLLIERFEIP
EPSLVYQEQQ QQTNSHAGIG TDSDKDAVTA TVDSDKMLKN SQREDWKRYR KEFVQPVQFR
VLNVLRHWVD HHFYDFEKDP TLLDRLLHFL DIVNSKSMRK WVESVRKIVD RKNKQSNKKI
VYAYGHDPPP VEYHLSVPEE EITLLTLHPL EVARQLTLLE FEMYKTVKPS ELVGSSWTKK
DKELKSPNLL KIIRHTTNVT RWIEKSIIEA ENYDERLAMV QRAIEVMMVM LELNNFNGTL
SIVAAMDTAS VHRLRATFNG LPERHRKFLD ECRELSEDHL KKYQERLRSI NPPCVPFFGH
YLTNILHLEE GNLDLLPNTE LINFSKRRKM SEIIGEIQQY QNQPYCLSEE PKYRHFFEQL
DPYNSLSDKE MSDYLFNESL RIEPRACKTV PKFPRKWPNI PLKSPGIKPR RQNQIQNSSN
KLSSNAPNSI EPVSANTAAV VSHAELGDHS PQHNPQAFSV FAHVLIPERN GSNSWSGAPM
QRAIDNGEVA PHLPRKPGAH VWTQSGNAPA ATAVTDAFSP ALSEQQVQLG NWAVSLSESY
LGTDMSDVLP PSPLPKLLVS PRHEASHFAP QQTGNRSPFH ERHTQTQYSP THSIASTVTL
IGAGFGDVSP TLGGFYYNHE HGHGHGQSGA VPISPHVNVP TASHLEYRAV PPPLPPRRKE
RTESCADMAQ KRQAPDAPTL PPRDGELSPP PIPPRLNHSI VSGYARHSHQ PKEFVSRSSS
LLLPNTSSIM IRRNSAKQPS LDSSSATHTA AGAGTPSTTV INVEQSAMLG DESQLQQQQQ
LHQPPQSISP ALSSSTTTSP MTPITPMSPS PYISSAIESS TSNTYPHQLQ HQTRLRPQPA
QQMVYSQHHH AHGHAHHHHH PSQHPNRRSS PKEFFPLTAS HSDGTPKLPP KPSLSANFYN
NPDKGTMFPY PSTNQE
//
