ID A0A0M4EIC4_DROBS Unreviewed; 431 AA.
AC A0A0M4EIC4;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=CG31065 {ECO:0000313|EMBL:ALC46396.1};
GN ORFNames=Dbus_chr3Rg1146 {ECO:0000313|EMBL:ALC46396.1};
OS Drosophila busckii (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC46396.1, ECO:0000313|Proteomes:UP000494163};
RN [1] {ECO:0000313|EMBL:ALC46396.1, ECO:0000313|Proteomes:UP000494163}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole larvae {ECO:0000313|EMBL:ALC46396.1};
RA Zhou Q., Bachtrog D.;
RT "Ancestral chromatin configuration constrains chromatin evolution on
RT differentiating sex chromosomes in Drosophila.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC ECO:0000256|RuleBase:RU000679}.
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DR EMBL; CP012526; ALC46396.1; -; Genomic_DNA.
DR RefSeq; XP_017844798.1; XM_017989309.1.
DR AlphaFoldDB; A0A0M4EIC4; -.
DR GeneID; 108601411; -.
DR OMA; QRIGIYE; -.
DR OrthoDB; 3684169at2759; -.
DR Proteomes; UP000494163; Chromosome 3r sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR InterPro; IPR001873; ENaC.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR PANTHER; PTHR11690:SF184; PICKPOCKET 29, ISOFORM D-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000494163};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 6..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 431 AA; 49361 MW; 600FF77F4DB6D0BE CRC64;
MNWIRYLPLA LKGLFYVVTL GISIPFIASV SRSLLKSFVS SSVSFNLDTI YLNWNTTFPA
ITVCELYNSE KIWDLSDSHF GIEHELHIDD FISDIAFFRG ICISCENCHR LPCPDNFTML
LEVFRSKCHE LIIECSYLNH IFDCCDQFLP LHTEYGVCYS FNSNQAHKSY LAQYKNNRQT
GAGHLKFHAA ADIQLHVHAP IDIPFPFAEG MVRDTVLLGS YKEIILNVIE VYNHESVNEL
SPEQRRCRYS NEHLPEGLGL YEFYSYSGCI IDCTVAKHLL YCNCTSHFMA MSSSNLLPVC
DYRGLICLTN NHDRVLAERK SCECMSSCEE PEYNIIHNTA DDNQEAEREA SDIHVALIEL
PTQRYVRRVA KSNLDLLIAV GGLVSLFFNT SLLRILEGIY LCFKYRKVIT QFAVGFLVGT
FKYLQILTKL K
//
