ID A0A0M4EIH7_DROBS Unreviewed; 2414 AA.
AC A0A0M4EIH7;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Cher {ECO:0000313|EMBL:ALC46484.1};
GN ORFNames=Dbus_chr3Rg1234 {ECO:0000313|EMBL:ALC46484.1};
OS Drosophila busckii (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC46484.1, ECO:0000313|Proteomes:UP000494163};
RN [1] {ECO:0000313|EMBL:ALC46484.1, ECO:0000313|Proteomes:UP000494163}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole larvae {ECO:0000313|EMBL:ALC46484.1};
RA Zhou Q., Bachtrog D.;
RT "Ancestral chromatin configuration constrains chromatin evolution on
RT differentiating sex chromosomes in Drosophila.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR EMBL; CP012526; ALC46484.1; -; Genomic_DNA.
DR SMR; A0A0M4EIH7; -.
DR STRING; 30019.A0A0M4EIH7; -.
DR OMA; VPTHEGY; -.
DR Proteomes; UP000494163; Chromosome 3r sequence.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd21311; CH_dFLNA-like_rpt1; 1.
DR CDD; cd21315; CH_dFLNA-like_rpt2; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 22.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537:SF18; FILAMIN-A; 1.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 22.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 22.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 22.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 22.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000494163};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 31..136
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 155..258
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 265..363
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 365..463
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 464..560
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 560..651
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 654..750
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 751..839
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 847..939
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 940..1032
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1033..1133
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1134..1226
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1227..1325
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1326..1421
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1443..1516
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1526..1627
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1627..1719
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1717..1807
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1810..1902
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1900..2000
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2003..2095
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2097..2190
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2192..2283
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2320..2414
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
SQ SEQUENCE 2414 AA; 261061 MW; 80558BA14AC994F2 CRC64;
MAARKSEQYE ENFDEDMEAE RDLAEDAQWK KIQQNTFTRW ANEHLKTIDR SINNLETDLS
DGLRLIALIE VLSQKRLPKH NKRPTFRSQK LENVSVALKF LQDEGIKIVN IDSSDIVDCK
LKLILGLIWT LILHYSISMP MWDGEDEKQL NGSGPTPKQR LLNWIHARIP DMPINNFTND
WTTGKAVGAL VDACAPGLCP DWELWDPKDA VQNASEAMGL ADDWLNVRQL IKPEELVNPN
VDEQSMMTYL SQYPNSKLKS GAPLRPKTNP NRVRAYGPGI EPIGPVVGAP ANFTVETFSA
GKGVVDVQIE GPNGVVEKAD VRFNNDKNLT YTISYIPKAE GLHKVTVLYS GRDIPKSPFP
VKVEGHAGDA SKVKVTGPGI QPSGVTIKKG TFFDILTKDA GRGVPEVIII DPANHKTSVA
AKVRQLEEDT WRCEYMTAMQ GLHSVNVFYA GTPIPNSPFP VKVAPLSDAR KVRVSGRGLQ
ATGVRVGDDA DFKIHTEGAG EGVPDVRVIG PGGMNQNVMQ SKIDGNTYEC HYYPTKEGRY
VVMVTYSGQE VPKSPIEVKV GPKKESSIVA YGPGLSSGVI GYPAAFVVET NGETGALGFT
VAGPSQAEIE CHDNGDGSAL VKYHPTAVGE YAVHILCDNE DIPKSPFIAQ ILPRTDFHPE
LVKASGPGLE KNGVTINQMT SFDVDTSKAG NAPLDVVVQD VYGNKLPVQL KSNPDGTKKI
SYTPTSGVPH TVEVNYGGVS TPNSPHRIYV GVPVDASKVQ AFGPWLQPGV RPNAPTHFNV
DAREAGDAEL KVKVVHEETK LDVPCRIIDN EDSTYSVEVI PPMKGAYTTT MTYGGQRVPL
GQKVVVEQTV DVSKIKVDGL EPTAPLNSLQ QFRIITHGLP KADLAVTITS PSGNRVKAHI
IPTAEGFLVN FTPTQLGEYL LSICFGGTPI TPRPFRLQCL TGSDSNKVHA YGPGLERGIV
GQPAEFMIDT RGAGQGGLGV TVEGPCEAAI NCRDNGDGTC NVAYLPTEAG DYSVNITFNE
RHIQGSPFQP LIVPLPNLKN TRVSGIGIQP HGVIMNAATD FTVDMSKVGS NIDSGKLSCA
IFDPMGHVLP NKMMGPTDDI FRIMYTPFEA GRHTIELMYD NIPVPGSPFV VNVKSGCDPT
RCKAYGPGLE KGLTNQKNKF TVETKGAGNG GLSLAIEGPS EAKMTCTDNR DGSCDVDYLA
TDPGEYDITI RFADKHIPGS PFRVLVEETV DPSKVKVYGP GIEHGQVREG VPTLFNVDVG
EAGPGRIAVK LTNSEGIPVD NLSVEDKGNC IYAVHYVPPK AGSVLTCQVK FADVEVPCSP
FVMTVFPKSE ATKVRVKGVN EKKKTPASLP AEFEIDTKQA GQADINVAIK NPKGKPMQPR
LEEVASGTYV VSFVPDECGT YQCSIKYGDK EIDGSPFKLE AFPTGEAKKC KLVEQVPKIL
PSGSQSHLKV DAREAGDGAV TCKITNKEGS EIVDIDVIEK DGVFDILYAL NDPGDYDINV
KFGGKDIPNG SFSIKAVESI EQYSHSEYVE EHTTKVIQQT TKSELVNGKS EVSYRSVAFE
KLPLPTTGGN VTAEVKMPSG KIDKPIIQDN RDGTVSVKYD PREEGSHELT VKYNGEPVQG
SPFRFHVDSI TSGYVTAYGP GLTHGVTGEP ANFTISTKGA SAGGLTMAVE GPSKADIKYH
DNKDGTVSVQ YLPTAPGEYQ VSVRFGDKHI KGSPYFAKIT GEGRKRNQIS VGSCSEVTMP
GDITDDDLRA LNASIQAPSG LEEPCFLKRM PTGNIGISFT PREIGEHMVS VKRMGKHINN
SPFKVTVCER EVGDAKKVKV SGAGLKEGQT HSDNIFSVDT RNAGFGGLSV SIEGPSKAEI
QCTDKDDGTL NISYKPTEPG YYIVNLKFAD HHVEGSPFTV KVAGEGSNRK REKIQRERDA
VPITEIGSQC KLTFKMPGIT SFDLAACVTS PSNVTEDAEI QEVEDGLYSV HFVPKELGVH
TVSVRYSEMH IPGSPFQFTV GPLRDSGSHL VKAGGSGLER GVVGEAAEFN VWTREAGGGS
LAISVEGPSK ADIEFKDRKD GSCDVSYKVS EPGEYRVGLK FNDRHIPDSP FKVYISPDAG
DAHKLEVQQF PQGNIQADAP YQFMVRKNGA KGELDAKIVA PSGTDDDCFI QVIDGEMYSV
RFYPRENGIH AIHVKFNGVH IPDSPFRIKV GKDVADPAAV HATGAGLDDI KTGHKTDFII
NTCNAGVGTL AVSIDGPSKV AMDCTEVEEG YKVRYTPLLP GEHYITVKYN NMHIVGSPFK
VHATGDKLAD EGAQETSTVV VETVQKVAKG GKNTGVHLPT FKSDASKVVS KGMGLKKAYI
GKQNQFSICA TDAGNNILYV GMYGPKGPCE EFHVKHAGHN NYNCQYVVRD RGQYVLLIKW
GEDHIPGSPF QIDV
//
