ID A0A0M4EKB3_DROBS Unreviewed; 1971 AA.
AC A0A0M4EKB3;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Mbc {ECO:0000313|EMBL:ALC47596.1};
GN ORFNames=Dbus_chr3Rg2346 {ECO:0000313|EMBL:ALC47596.1};
OS Drosophila busckii (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC47596.1, ECO:0000313|Proteomes:UP000494163};
RN [1] {ECO:0000313|EMBL:ALC47596.1, ECO:0000313|Proteomes:UP000494163}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole larvae {ECO:0000313|EMBL:ALC47596.1};
RA Zhou Q., Bachtrog D.;
RT "Ancestral chromatin configuration constrains chromatin evolution on
RT differentiating sex chromosomes in Drosophila.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; CP012526; ALC47596.1; -; Genomic_DNA.
DR RefSeq; XP_017848455.1; XM_017992966.1.
DR SMR; A0A0M4EKB3; -.
DR STRING; 30019.A0A0M4EKB3; -.
DR GeneID; 108603829; -.
DR OMA; LWDNQAF; -.
DR OrthoDB; 8258at2759; -.
DR Proteomes; UP000494163; Chromosome 3r sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd11697; DHR2_DOCK_A; 1.
DR CDD; cd11872; SH3_DOCK_AB; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF10; MYOBLAST CITY, ISOFORM B; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000494163};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 9..71
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 442..621
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1250..1661
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1689..1755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1771..1890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1938..1971
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1689..1733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1771..1801
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1807..1829
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1832..1860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1971 AA; 226406 MW; C5EF58D78F2EB534 CRC64;
MTVWSDCNAK QTFGIAKCNF DQDAKPHRLN LDVGDAVIIL KETTHWYYGY KQKAKETRGI
FPKSYVHLCE YSIVNGEYCI QRTDIVEEIT KVLLEWGGIA KEYFLTTNPS FQKIRRKMNN
LNNNRAALIS GNLPLDEMRK VKLQATALID TGNRLLGLDM VVRDESGDIL DTNAICTTEL
YENHVNAMQR IDKANRLSGE RETPRIQNKY SHNILLHVNA FVCKFREDSD LLFTLFDGES
HKPISENYVV KWSRSGIDRD IDQFNNNRVL FTDLSRSDLN ISKLYLVCYA IRIGAMEIKD
TTDSKRISMN MGIGNSSNIK QSQLSINSNA STSSNGSDYM LRRPFGVACK DLTPYLSKPD
DFRGNLDLPF IMCEKDTLDG TLRKMIANKD LGKLDSKMAV TVEVLRGDIK QIKEDFPRLV
HTNVPVARKM GFPEVILPGD VRNDLYLTIC SGEFARIAKT SEKNVEVTVC VANEQGQLVP
GVLSIGAGHP PIDEYKSVVY YHDDKPKWQE TFKIHVPIEE FKLCHLRFML KHRSSNEQKD
RNEKPFGLAY VRLMQANGTT IPQGQHVLAV YKIDHKKHDK SMANSYMELP ATTAELLGTK
PSISGLTLLP KDQLTIGVNL CSTKLTQSVS LLGLLHWSAH KETLEQSLNA LSTVPGEEVV
KFLQDILDAL FNILVENDQP EKYDQLVFMS IIHLIETVSD LKYQHFLTVL DVYIKDSFSA
TLAYTKLIDV LQRNISEAIT PSEKSVDGIE LQETLPVRRL YKTTRYLHYV MKFIIRSRIL
YSAMNCNTDY VEFATRLQEL LKMFIDMIGC PSNLLKSEGA LLKNLHIIAT DLMQVFDQVH
LSTSIVEILE KFPSRRLTQS KMGCIKDFVE TKLFSMPKCR AILLPVFCKH IKDHLESKEE
IAECINIMNN ILKLLYRPDV GPTHNDVRDI MIILLRPVMK MAHALDRDRD VVGQFFAIML
GIMQRMDAQH YKYFVNDLHQ HGELKDFVIE ILLVFEELVS PHQKAVFPRD WMDMIMHQNT
VILGALQQLS LVINDYFLCP VFDKQIWSNF FQCSIAFLVQ SPLQLNDFND NKRQIVFARY
RDIRKDTAKE IRKMWFQLGK HKPKFVPQLV EPILEMSMIP EMELRRETIP IFFDMMQCEY
YSSRLEMESY GDTKHNSSHY KGNFCEFKTA MIEKLDILIG MGKGDAEYKE LFEQIMLEYC
AKHNTLNMEG TSFVAMVTKL MDKLLEYRCI IQDESKENRM ACTFSLLQFY SQVDLKEMYI
RYVYKLCALH MEFENFTEAA FTLKLHTDLL RWSDEELSPQ LRSHRHGHCR THRELKEALY
FEIMEYFDKG KQWECAIDMC KVLSRQYEEE IYDYIKLAEL LKRMALFFEK ILKELRHTSE
YFRVCFYGLG FPRLLQNKVY IFRGKEYERH SDFCSRILVQ HPQAELMQTL EAPGEDITAS
DGQYIQVNKV EPIMDAAFAK FNEKIISNEI VKYFTSNNVQ KFQFSRPFRD STGGGDDVRN
LWLERTELIT QFPLPGILRW FPVVDAHTFK ISPLERAVEI MKKTNTDIRQ LVILHQSDES
LHINPLSMKL NGVVDPAVMG GFAKYEEAFL TDEYLEQHAE DKELVEELKE LIASQIPLLS
IAIRLHRQKA PESLKALQDH LERCFADMQQ HVESRYGRKS CDLKIERDSV IMRRTNSFLP
AIFDSSNNRL SETSMGSSDS GLSKSTFLPR PPTSSLKSTF ASLRPNLGHS PSTKSNKLKD
KTPAKRRSMK KDRDTLSLPV ASCQWYTPPL MTITSTPEKE NTTSISSLAS TSNTSLSGPK
TPDPRVLTEE LTPKRPLRSE KEKERRLSRP ASIATPTASI KNFTDNRSLS ESSNRNSVET
TDSTSEEDIR PPPLPAKTRD STDFSSLSWN PNTYSMLNVL GSNTTNSSSS ISTTTTMTMT
SITNNTYEYL EATNYSLMTG FQDASKPRPP TPPPKPSRHS KHIPTEQVAA P
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