ID A0A0M4EP83_DROBS Unreviewed; 616 AA.
AC A0A0M4EP83;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=CG31033 {ECO:0000313|EMBL:ALC46614.1};
GN ORFNames=Dbus_chr3Rg1364 {ECO:0000313|EMBL:ALC46614.1};
OS Drosophila busckii (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC46614.1, ECO:0000313|Proteomes:UP000494163};
RN [1] {ECO:0000313|EMBL:ALC46614.1, ECO:0000313|Proteomes:UP000494163}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole larvae {ECO:0000313|EMBL:ALC46614.1};
RA Zhou Q., Bachtrog D.;
RT "Ancestral chromatin configuration constrains chromatin evolution on
RT differentiating sex chromosomes in Drosophila.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the WD repeat ATG16 family.
CC {ECO:0000256|ARBA:ARBA00009271}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP012526; ALC46614.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M4EP83; -.
DR SMR; A0A0M4EP83; -.
DR STRING; 30019.A0A0M4EP83; -.
DR OMA; IPSTCRI; -.
DR Proteomes; UP000494163; Chromosome 3r sequence.
DR GO; GO:0000045; P:autophagosome assembly; IEA:InterPro.
DR CDD; cd22887; Atg16_CCD; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR045160; ATG16.
DR InterPro; IPR013923; Autophagy-rel_prot_16_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19878; AUTOPHAGY PROTEIN 16-LIKE; 1.
DR PANTHER; PTHR19878:SF8; AUTOPHAGY-RELATED 16, ISOFORM F; 1.
DR Pfam; PF08614; ATG16; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000494163};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 11..196
FT /note="Autophagy-related protein 16"
FT /evidence="ECO:0000259|Pfam:PF08614"
FT REPEAT 316..349
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 360..401
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 402..443
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 460..485
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 218..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 40..92
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 128..190
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 220..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 616 AA; 68965 MW; 877D4496C6F09EC3 CRC64;
MSAEEYVWRE HIVRRLREKR KGCEGFKEII IQNNRLIDHV AQLKSDNLKL SVENEQLRNA
VSTGGTGPNV AMVTLEKKLL AQQEELTELH KRKGENSQMI VDLNVKVEQQ KKLLVEKEHS
LYEQQTVNNR LRAEVQLLHC SLEELKKLNT TLLDEHTALQ LAFSSLEDKM RSVQDENRCL
LERIMRYKSK DADKLNEENE SIIRKRSAKL KRDLEDAVRE PNSLNNQTVP ASSGTPLHRN
STSPAQFVGS LVSDDDFDEA SINGAMEALG LDEDEYINAR FSAGEAMHEA TRASIDTLKA
SGYLGQPNPT KILMKFEAHE NESHAVRWSP VERMVATGGA DRKVKLWDVG KGLTEPRAVL
SGSSAGINSV DFDSTGAYIL GTSNDYGARV WTVMDNRLRH TLTGHSGKVM AAKYVQEPIK
VVTGSHDRTL KIWDLRSIAC IETKFAGSSC NDLCTTDSLG STIISGHYDK KIRFWDIRTE
KQADDVLMPA KITSLDLSKD CNYLICSVRD DTIKLLDLRK NQVISTFANE HFKISCDFAR
ATFNSSAVKI ACGSADGTIF IWNVNGFLET TLKGHRNDYD LNIFRSTAVN AVSWSPNSNS
LASVGKSKRC IIYSDS
//
