ID A0A0M4EPU4_DROBS Unreviewed; 3868 AA.
AC A0A0M4EPU4;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Dhc36C {ECO:0000313|EMBL:ALC38670.1};
GN ORFNames=Dbus_chr2Lg755 {ECO:0000313|EMBL:ALC38670.1};
OS Drosophila busckii (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC38670.1, ECO:0000313|Proteomes:UP000494163};
RN [1] {ECO:0000313|EMBL:ALC38670.1, ECO:0000313|Proteomes:UP000494163}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole larvae {ECO:0000313|EMBL:ALC38670.1};
RA Zhou Q., Bachtrog D.;
RT "Ancestral chromatin configuration constrains chromatin evolution on
RT differentiating sex chromosomes in Drosophila.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; CP012523; ALC38670.1; -; Genomic_DNA.
DR SMR; A0A0M4EPU4; -.
DR STRING; 30019.A0A0M4EPU4; -.
DR OMA; GRDIPCS; -.
DR Proteomes; UP000494163; Chromosome 2l sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46961:SF9; DYNEIN HEAVY CHAIN, CYTOPLASMIC-LIKE PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR PROSITE; PS00978; FAD_G3PDH_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000494163}.
FT DOMAIN 747..1151
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1281..1607
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1773..1922
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2142..2218
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2299..2561
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2577..2919
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 2949..3168
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3413..3527
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3562..3702
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3778..3856
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 671..731
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2811..2845
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3868 AA; 443699 MW; 7CDD2DDC0D6DCA4D CRC64;
MKKNNPNKEI PSFTSVCGAR RLCEKSKMLY TRPKPDVLES ILQSKANSDY KSRRLWYELN
MPECASRLFD GQMLSDLPED LICAKTRERR KRARKLEEKE AKGSSNYMAM RQERENFRRK
LVELILHMDD DQDHGPSGNA ETPFPDQGER ETLRYYYYIK HGIDTIHVST INKKTLKRIT
NLVPELLKKW EVALVENIAE VRADYVFAMK KAVVDFVLRH SALDRLTKEG VPAKFDTAER
REIKHMMNHW RYRYDENRNR LKKTLFCIHR SVASILEVWS MKYTNKMLVN IDELSKVEQP
FTLFSFVYLC GSHIDLGKQM LEDVWYGEIH TTLLRASKRG QLPDIRRMTL VKRFFNCVAA
LMTQQLEDIC IRSLKGFANY VCDFGHSNPG LEISIVLADE DTITFTPGFS KIQSELLRVI
DSIVVAIHNM PRIEGKLYTD LKISKKYYLT PAIPDSVIAE AKNKICAMLE EQRIGPELRL
QDFDQFIDLI NGSDAERVSR FMESDATFEQ YCDMVYEYKE KEDRIAKEVW GVIRMGLYEF
HREKFIEHME QLARRLQLDL LARMVTDQQA RISRLGKEYD AIAKKALTVP KDTAELMSLK
AYVVQAEENM APDMEARLKV NMGEILWLMD HTLYSPLEIK NNSNSFQWYL RLPSVFEQHR
VIIAEKVIEY QELLKKRIEM FRRELQNYYD QVQTYDTWGD FKQLSKYKKR ATLLDQRLVN
AMETIDQINE EETAYGWDLS QYPVRKKAHD QLKPYKNLFD AGQDFIDKWE LWMHSQVGSF
DPDQIDTDVA NFYRIIQKLE KQMGDHPHTM QLILDVKEQI EQFREHMPII NTLGNPGMKA
RHWEQVSEII GFPIKVSPEL TLEKIIEYQL DEYVPKFEAI SESATKENNL EKAMIKMANE
WEGVEFTISP YRDSGTYKLS SVDDIQILLD DQIIKTQTMK SSPYIKPFEA DILKWEAKLM
LLQEILDEWL RVQATWMYLE PIFSSPDIQQ QMPEEGRRFS AVDKIWKELM KQVASDPRVM
TVVQIDKMND KLKKAYSLLE IIQKGLNAYL EKKRLYFPRF FFLSNDELLE ILSETKDPTR
VQPHLKKCFE GIATLNFTEE MEVTAMRSSE REEVVLADVI STAKARGQVE RWLLELEIDM
KKSLHRKISE AFYSYVKMKR DIWVLTWPGQ CVQSISLTYW TLEITECFMT ETPVESLAKY
LQKCVSQIAK IVDLVRGDLN TQNRITLGAL VVLDVHARDV LAEIVEKEVS DLQDFQWLCQ
LRYYWEENNL DTRMINCSLP YGYEYLGNTT RLVVTPLTDR CYRTLFAALN LHLGGAPEGP
AGTGKTETTK DLAKAVAKQC VVFNCSDGLD YLALGKFFKG LASCGAWSCF DEFNRIDLEV
LSVVAQQILT IQRGINSGSP TLVFEGTTLT LDPTCAVFIT MNPGYAGRSE LPDNLKALFR
SVAMMVPDYA LISEIELYSY GFLTAKPLSI KIVATYRLCS EQLSTQCHYD YGMRAVKSVL
KAAGALKLRY RDENEDILVL RSIKDVNLPK FLNQDIPLFQ GITSDLFPGV TLPEADYVVF
NECAMKACEK QNKQCTPFVL EKVQQLYEMI VVRHGLMLVG YPFGGKSTTY RILADALECM
ELKDGSENRA IYTIINPKAI TMGQLYGQFD AVSHEWSDGI LAVNYRIFAV SDTPDRKWLI
FDGPVDAIWI ENMNTVLDDN KKLCLMSGEI IQLSNTTNLI FEPMDLEVAS PATVSRCGMI
YLEPSSLGWE PLVTSWKNTL PPSFHNVSKN LISTLINRFC PILLFIVRKS LREIAPTSDT
NLMVSLMNFF ECFIDDFKDE KIVATISDLD FRAQIEGIFM FSAIWSLGGS LAAESREKFN
LIFRALMEKT FPQSMYETYG VTEDLYVEPL AKPFIFPIPK QGSVFDYRYI KEGKGKWKPW
QDDVNAAPPL PRDIPVNQII IQTNESVRIA AVLDLLVRHN KPLMLCGPTG TGKSVYIIDY
MLKRMDLNTF KPLLISFSAQ TSANQTQDII MSKLDKRRKG VFGPPLNSKF VIFVDDVSMP
LKENYGAQPP IELLRMMLDH MMWYDRKAIV PMKLIDLQMI TAMGPPSTGN TVTPRFQRFF
NVVSIDDFND DIMKTIFSKI VLWHLDARGF SKEFDPCIDE IVNATLSVYN DAKLNLLPTP
TKSHYLFNLR DFSRVIQGVL LSVPEATEDM NSMRRLWVHE VLRVYGDRLV EDSDRTWLFQ
KLCKTCEAAF EVDASRLFAR LVSKGKSLEE SDFRQLIYCD FTNPKADTKN YVEVQDLEEL
RSVVEAYLVE YNNMSKKPMN LVLFRFAIEH LSRICRIIKQ PRSHALLIGV GGSGRQSLTR
LASHICDYEL FQVEITRLYG PYEYHEDIKA ILRKIGAGEM HGVFLFTDVQ IKDESFLEDI
NNLLNSGEVP NLFSNEEKIE VVEKMAQIDK QRDKAVQTDG SPVALFNFFV TTCKDQLHIV
LAMSPIGDAL RNRIRKFPSI VNCCTIDWFQ SWPEDALLAV STRFLATEDL TALERRTAID
MCMEFHTSTQ ILSAKFFSRL RRYNYVTPTS YLELIQTFKS LLSQKRTNIT NNRNRYLTGI
SQLDIAAQQV SVMQEQLQAL EPKLKEASEI VAEQVAKVTA DSKIAAEQRE MVKEDEQAAK
QQAAVAQEIK DECDAKLGEA LPILEAALSA LNTLTTADIA VVKTMKSPPI GVRIVMEAVC
ILKDVKPEKV PNPSGVGTVE DYWGPSKRVL SDMKFLDSLL NFDKDNISPE IMKKLQQRIL
NNEAFDPDKI KMASTACEGL CRWVIALSKY DVVAKIVAPK KIALAAAEAT YNAAMKLLNE
KLAQLARVEA NLAAIQKILD EQLRQYGILL AEHEACTKKL QRAQELISGL GGERTRWSET
AKMLQGSFKS VTGDVLISSG VVAYLGPFTI DFRVKQIRKW VTKCIDFGVH CTPDFQLAVV
LGEPVEIRFW NICGLPTDAF SVESAIMMKN ARRWPLMIDP QGQANKWIKN YEKSNKLCVI
RLNQPDYTRV LENAIQFGLP VLLENIGEEL DPVLEAVLLK QLFKQGGALC IKLGDSVIEY
NFSFRFYMTT KLRNPHYLPE VAVKVTLLNF MITTQGLQDQ LLGITVARER PDLEAEKNNL
IVQGAENKRM LKETEDQILE VLSSAENILE DETAVQILSS AKALANDISE KQIITEATEK
QIDIARLSYV PIAEHSTILF FTIVELANID PMYQYSLVWF VNLYMASIDN TEKVDDIDAR
LKDLRNHFTY SLYVNICRSL FERDKLLFSL ILNINLMKHE NLIDNGEWMF LLTGGIGLEN
PHKNPASWLG VQNWDEVCRL SSLPNFKGLR EDVTANPDRW KLMFDAKSPQ DLAAIPADWK
KRITMFQQLL ILRVFRPDKL VPAVLNFVAT ELGPKFVDPP QFDLSASFGD SHCCVPMIFI
LTPGSDPTAT LLKFAEDQGF GTNRLFSLSL GQGQGPIAIK MIDEGVKLGN WVVLQNCHLA
ASFMPSLEKV CENLLPDSTH PDFRLWLTSY PAEHFPVVVL QNGIKMTNEP PKGLRSNILR
SMISDPISDP EWYESCTQPR VFKQLIYSLC FFHAVIQERR YFGPIGWNIP YEFNETDLRI
SLMQLRMFLN QYETVNYDAL RYLTGECNYG GRVTDDWDRR TLKTLLDLFY CPAILDLEKP
HFLDDTGLYY VPVFKELDMY LNYTRDLPQI SAPAIFGFHA NADIMKDQQE TDMLLSHTLL
TQDLYDKRKL EKTQRVYVDV LSRRYPENLC LPNYPTCPPF LSLYNMPLKD TSAAGDDSEG
SKALTPEEVV TNVATDILDK LPKLFDREAA LLRYPTIYHQ SMNTVLVQEM VRFNVLLNTI
RTSLITLRKG IKGKFISIAK VAYLFVTS
//
