ID A0A0M4ERB9_DROBS Unreviewed; 690 AA.
AC A0A0M4ERB9;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=CG33120 {ECO:0000313|EMBL:ALC39407.1};
GN ORFNames=Dbus_chr2Lg1492 {ECO:0000313|EMBL:ALC39407.1};
OS Drosophila busckii (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC39407.1, ECO:0000313|Proteomes:UP000494163};
RN [1] {ECO:0000313|EMBL:ALC39407.1, ECO:0000313|Proteomes:UP000494163}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole larvae {ECO:0000313|EMBL:ALC39407.1};
RA Zhou Q., Bachtrog D.;
RT "Ancestral chromatin configuration constrains chromatin evolution on
RT differentiating sex chromosomes in Drosophila.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol
CC + CoA; Xref=Rhea:RHEA:10868, ChEBI:CHEBI:17815, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:58342, ChEBI:CHEBI:64615; EC=2.3.1.20;
CC Evidence={ECO:0000256|ARBA:ARBA00001039};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a fatty acyl-CoA + a long chain fatty alcohol = a wax ester +
CC CoA; Xref=Rhea:RHEA:38443, ChEBI:CHEBI:10036, ChEBI:CHEBI:17135,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:77636; EC=2.3.1.75;
CC Evidence={ECO:0000256|ARBA:ARBA00029340};
CC -!- PATHWAY: Glycerolipid metabolism; triacylglycerol biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004771}.
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the long-chain O-
CC acyltransferase family. {ECO:0000256|ARBA:ARBA00024360}.
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DR EMBL; CP012523; ALC39407.1; -; Genomic_DNA.
DR RefSeq; XP_017835216.1; XM_017979727.1.
DR AlphaFoldDB; A0A0M4ERB9; -.
DR STRING; 30019.A0A0M4ERB9; -.
DR GeneID; 108594523; -.
DR OMA; APDHTII; -.
DR OrthoDB; 3680232at2759; -.
DR Proteomes; UP000494163; Chromosome 2l sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004144; F:diacylglycerol O-acyltransferase activity; IEA:InterPro.
DR GO; GO:0045017; P:glycerolipid biosynthetic process; IEA:InterPro.
DR InterPro; IPR045034; O-acyltransferase_WSD1-like.
DR InterPro; IPR009721; O-acyltransferase_WSD1_C.
DR InterPro; IPR004255; O-acyltransferase_WSD1_N.
DR PANTHER; PTHR31650:SF23; GH11223P; 1.
DR PANTHER; PTHR31650; O-ACYLTRANSFERASE (WSD1-LIKE) FAMILY PROTEIN; 1.
DR Pfam; PF06974; WS_DGAT_C; 1.
DR Pfam; PF03007; WS_DGAT_cat; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000494163};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 110..253
FT /note="O-acyltransferase WSD1-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03007"
FT DOMAIN 545..686
FT /note="O-acyltransferase WSD1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06974"
SQ SEQUENCE 690 AA; 79796 MW; AD70310065455515 CRC64;
MESVWLECVS FLKTLLCFIV ALMLMPLLLL SFLCAHFGNE LANYLLSIKY PNLTISKSKK
IRTLIDTPKN AGIFHFLLQV EGPCEFEHIN RAYSTQLIEL KDKTGVLRYP MLRQQLVTCW
GHYAWVNDSS GFNINNHVLL STPKYRGRAV SESNIQEYVS ELAAKYIPSD LPQWQVTVIP
NSDDTQPYYI LIKVHHLIIA EEQDLHVSEM LLLQDPEKKS FVDALTATTP AVSKQLSHFV
RQPEHISKLL QHVQHLISCR WQQFIYEFES LDTPDGVKSQ PDARNLSQLL SLSLIVLVNV
SLSYWRQRAL RRKLKHRSGH SYRHDVGMLQ TIYILLVREL EQRNLNWTVA RAALTHSLQP
LNMVKCWTRF IWHLLLHNFI LLPYYVYYEL LALRDVLLRG QTSYSDTHCA RLYLYVPLLF
YAQLELVKIC YELFMAPRNI YDVLFVQPTK ELNILHQKSY AGRKIVSFSR SIDGSQLRER
HEHMFGQQLR ESDFSLACLA GAVHDYFNTY TDKAAVPALL NTTCRTIAQG YFTDRSGDKS
SHIGGVIFLQ LPLGPPDALK ALQLHEIVER IRKQQIMIYL ASIGQTKYSL LTSLLPHVLT
KIFINFFSYN FPVTITEVYG PADPQFQAAW GQRVQDVLLF RPPQSKTCLS LNLHRYGDRY
RLAVMADTHL APDHTLLTRS FERYMETVAL
//
