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Database: UniProt
Entry: A0A0M4ESM8_DROBS
LinkDB: A0A0M4ESM8_DROBS
Original site: A0A0M4ESM8_DROBS 
ID   A0A0M4ESM8_DROBS        Unreviewed;      2774 AA.
AC   A0A0M4ESM8;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   ORFNames=Dbus_chrXg220 {ECO:0000313|EMBL:ALC48364.1};
OS   Drosophila busckii (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC48364.1, ECO:0000313|Proteomes:UP000494163};
RN   [1] {ECO:0000313|EMBL:ALC48364.1, ECO:0000313|Proteomes:UP000494163}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Whole larvae {ECO:0000313|EMBL:ALC48364.1};
RA   Zhou Q., Bachtrog D.;
RT   "Ancestral chromatin configuration constrains chromatin evolution on
RT   differentiating sex chromosomes in Drosophila.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC       {ECO:0000256|ARBA:ARBA00010769}.
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DR   EMBL; CP012528; ALC48364.1; -; Genomic_DNA.
DR   STRING; 30019.A0A0M4ESM8; -.
DR   OMA; FPYFLCY; -.
DR   Proteomes; UP000494163; Chromosome x sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd05171; PIKKc_ATM; 1.
DR   Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR038980; ATM_plant.
DR   InterPro; IPR003152; FATC_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR014009; PIK_FAT.
DR   InterPro; IPR044107; PIKKc_ATM.
DR   PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR   PANTHER; PTHR37079:SF5; SERINE/THREONINE-PROTEIN KINASE ATM-LIKE ISOFORM X1; 1.
DR   Pfam; PF02260; FATC; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   SMART; SM01343; FATC; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51189; FAT; 1.
DR   PROSITE; PS51190; FATC; 1.
DR   PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000494163};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          1717..2324
FT                   /note="FAT"
FT                   /evidence="ECO:0000259|PROSITE:PS51189"
FT   DOMAIN          2428..2741
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50290"
FT   DOMAIN          2742..2774
FT                   /note="FATC"
FT                   /evidence="ECO:0000259|PROSITE:PS51190"
SQ   SEQUENCE   2774 AA;  316960 MW;  7B3E1DDA6227F399 CRC64;
     MSGLLNELQR ITNDLHSEKA PTRNKAIEQL DQKLNNSKEA INDVLARKKE LSWQNVFEAT
     KEAIFRHAAN MLDAREKAFK ALADKRYLYG NAITKIIDYN LEIGRTNGAY FLDKSTVFNA
     FEEGLKQRGV VQHFGDHFIN ILDRGIYLSP SYVRDLKVSE YSRILSYLFE LNVDKDEFLH
     SKLLKCITKT LQLAQDRVQL HADLDGYLPA LISFAQEPHT ADRKCEIVRI YQLFVSQLAV
     NYHHNLCKHM QEIMPKLCEF HNDDVFRDDT KTIFFDCIIQ SLHALYPKLH NGDFDTFHVA
     LNESWPQTMQ KLKSIIHMEI RRNSMVRCKT SQLLSDKFSE EFIKMSSLVM YILLWHLETN
     RNADAAEAPN KRQRVDKMET MFNLIDKQET SFNDIWFAIC AELLLLSDCI INAANYQQIL
     QTTLDVLLID GNARNMRSVR QCLSSLLQKE QQLVQSQGMQ PNYLAEAWTQ IATHLIAEVQ
     PAATVIQEKQ LILQLMIRHQ KLSATLCSTL LQSITTTQML RRNECIATIR EIFKHAEHCG
     LDKTAAEMES IINWAFASDK SSATQMIHNI AALDAKLLAD TFAIGIINFL DEQQLKQLTS
     NATATPIAAS NLQLLQFKYN EQLVCLQQSF QLQLQVADSQ QSAVVIGNKN CLFQNNFELL
     MRLLNFGTSN EHCIGAILKD LKSLYKLVCF IERLLYYKVL DAQNFMQCVL IKRIGLFLSH
     IEFQYKANEL SSMDDCDLQD ILQQQLLVLD VFSSHPILLQ YLETQPIDML LEFIGAVLKQ
     NSTRRDPLES KDRSSLTLKC LHILGRVCAY SSWSHEAFKH ISQHIRAQSP PEHVLLVIKM
     LCSSSKLSDE CIGWLVDELK TLIQHHYLNA QIVSQLVDYM PVIFYFVYNL EQLLDDMLIA
     LMSMLKISMR KSYPTHISVK IISCVAEIAQ RCSNIYELDN FAVICKSVGK FLTMPTLEVR
     LKTLSTLTLL LNTNYCNEQL NAVGSSEQHL EFCEQLYETI DWNKLTFTSE DLKQNCISVI
     IQTLLAFFAY STYHQELALQ HLLEHCAEHK LTETDFSALK SNVPDRGQPL RELIKPYADV
     LLHNWISKQY SHSKFPYYLC FNTKEEYLNA HAGHILAYTL IYAKPEDVKR IDKSLSKESA
     LPVLLAYVLS DLADCDESES VLFRQHHDNL TKNLAQLKLN PLDLPLNATT LYNAIKLVLD
     KEQLAKLFGQ AVSCARMPMW YNLSVSSLFK CLKANIQGRS WSQDARIQWM SALMFEQPHV
     LIDLLIILKS DCYNAVISSH VLRCFFLYAI LAVATLDAVS ALEASAKAEP DSLLLTVHAA
     YFVRDAWYFS CRLLLATKCA QVQHAVLQLL QQLLSKGNFE AACLNAHMDD IAKILVQCVQ
     QLHQPHLKQQ AIGLLETIVD NYAEQLHLDS LLAEASETAE WLALRQKLAT NSPNSFELDV
     ASSIRVFLKS SRLQSLHTLR KYLAEHKHHL QDQEQLLLEL YNRLIRMVRE QEHSLEALKC
     LAELGPLKIK HISYYFQTDF DAPTEQPMEQ FLGSIMQTLE QHLFQFNIHT QQSLINVAID
     VVNSPSGRKL IAEHTNLRIF STKGSKASFL HASGSVRCID WLNLLRSCEH LDYESWLCTF
     MSRIFIACGW QGFDAFAGKC FSFAKACLQP FIKLLLADKD VHLESLCAML DYFFAKSCDS
     QASTGIYQEK RAIKRFLYMC ECVRFCNNWQ IPIKLSNVVR ASNHCQAYFL SIMYLELWAC
     SASATELTNS SILADEEFQN CAKTAYESIG CLDAIPGFLN PLRSRLDYLS LNNNICGILV
     ESDGLDMPNS QLCLDIMKSN GMLTFAKLQQ QQSQSKQLDY EILWRLGQWD EQVDGHQKVN
     TANNMELEFK KHHYMALKSI SNREEENTLS AINNAYICVQ HILRDISVEC LQSVYKYMTW
     LCTLQQATDF CQLQFGNHLS SDEINGTLDK WRTELELTYG NFNCKEHILT HQITLFKLAG
     TRANRRLQQY YKQTPVDTYL LKCIAECKAA GKLNLASKYI AMLRTMPEVK APTKISVLLE
     DAAVNARTGN YQTAKAILQH VVNHNEFQFC LQRVPALRLQ GEFLLDCNGE SMAHTLEHKF
     MGSLKLLEQF RKHKTLLMEK HPDIFAWQSF DAFENEQRMA AHEAIAKYAD REYQQLHDYR
     HSQEYEMLAH ITMHNLRLAG TVTDRQKAPE DRDRQVGAMH LKRFANLDEK ELQRIDDNLT
     EHLCTALEHY MHYCQLDGGH SNAKIYRIIA LWFTNAENAQ MLLQLKSSLH TVPSYKFICA
     VNQLAGRLGS KQDDFHKLLV ELLVRCAQEH PQQTFYKLYP LVYANMDGGH GNSQRADVAT
     KLIAKACQGN AALAVISKQF EAMFPALINF ANSYLEMPPK GGRPNIKGIP DKLKKLNLLK
     LTSVQCPTLE LAIQPSQQYN VNSIVRWKTS EFLVCGGLNA PIKLMCVCSD GLIRAQLIKG
     KDDLRQDAVM QQVFGFVNEL LSSEPEFIER KLQLRTYKVT PLSMRSGILE WCTNTLPVAA
     YLVGDGAGGA HLKYNPKDWT NRKCREMSLA VLRKPVAARQ EVYKEICKRV HPVFHYFLLE
     KFAIPGVWFE RRLAYTNSVA TTSMVGYVLG IGDRHTQNIL IDEKTAEVVH IDFGHAFEQG
     KVQATPETVP FRLTRDFVSA MGVCGTNGVF TKSCEATMHI LRRYKSVFAT ILEVLLYDPL
     FIWGVLSSNQ ATTSNESKNL LAQRALLLVQ HKLEGRESGL LGNASVETQV QRLINEATLP
     SNLALLYPGW DPYL
//
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