ID A0A0M4ESM8_DROBS Unreviewed; 2774 AA.
AC A0A0M4ESM8;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=Dbus_chrXg220 {ECO:0000313|EMBL:ALC48364.1};
OS Drosophila busckii (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC48364.1, ECO:0000313|Proteomes:UP000494163};
RN [1] {ECO:0000313|EMBL:ALC48364.1, ECO:0000313|Proteomes:UP000494163}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole larvae {ECO:0000313|EMBL:ALC48364.1};
RA Zhou Q., Bachtrog D.;
RT "Ancestral chromatin configuration constrains chromatin evolution on
RT differentiating sex chromosomes in Drosophila.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
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DR EMBL; CP012528; ALC48364.1; -; Genomic_DNA.
DR STRING; 30019.A0A0M4ESM8; -.
DR OMA; FPYFLCY; -.
DR Proteomes; UP000494163; Chromosome x sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05171; PIKKc_ATM; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038980; ATM_plant.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR044107; PIKKc_ATM.
DR PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR PANTHER; PTHR37079:SF5; SERINE/THREONINE-PROTEIN KINASE ATM-LIKE ISOFORM X1; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000494163};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1717..2324
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2428..2741
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2742..2774
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 2774 AA; 316960 MW; 7B3E1DDA6227F399 CRC64;
MSGLLNELQR ITNDLHSEKA PTRNKAIEQL DQKLNNSKEA INDVLARKKE LSWQNVFEAT
KEAIFRHAAN MLDAREKAFK ALADKRYLYG NAITKIIDYN LEIGRTNGAY FLDKSTVFNA
FEEGLKQRGV VQHFGDHFIN ILDRGIYLSP SYVRDLKVSE YSRILSYLFE LNVDKDEFLH
SKLLKCITKT LQLAQDRVQL HADLDGYLPA LISFAQEPHT ADRKCEIVRI YQLFVSQLAV
NYHHNLCKHM QEIMPKLCEF HNDDVFRDDT KTIFFDCIIQ SLHALYPKLH NGDFDTFHVA
LNESWPQTMQ KLKSIIHMEI RRNSMVRCKT SQLLSDKFSE EFIKMSSLVM YILLWHLETN
RNADAAEAPN KRQRVDKMET MFNLIDKQET SFNDIWFAIC AELLLLSDCI INAANYQQIL
QTTLDVLLID GNARNMRSVR QCLSSLLQKE QQLVQSQGMQ PNYLAEAWTQ IATHLIAEVQ
PAATVIQEKQ LILQLMIRHQ KLSATLCSTL LQSITTTQML RRNECIATIR EIFKHAEHCG
LDKTAAEMES IINWAFASDK SSATQMIHNI AALDAKLLAD TFAIGIINFL DEQQLKQLTS
NATATPIAAS NLQLLQFKYN EQLVCLQQSF QLQLQVADSQ QSAVVIGNKN CLFQNNFELL
MRLLNFGTSN EHCIGAILKD LKSLYKLVCF IERLLYYKVL DAQNFMQCVL IKRIGLFLSH
IEFQYKANEL SSMDDCDLQD ILQQQLLVLD VFSSHPILLQ YLETQPIDML LEFIGAVLKQ
NSTRRDPLES KDRSSLTLKC LHILGRVCAY SSWSHEAFKH ISQHIRAQSP PEHVLLVIKM
LCSSSKLSDE CIGWLVDELK TLIQHHYLNA QIVSQLVDYM PVIFYFVYNL EQLLDDMLIA
LMSMLKISMR KSYPTHISVK IISCVAEIAQ RCSNIYELDN FAVICKSVGK FLTMPTLEVR
LKTLSTLTLL LNTNYCNEQL NAVGSSEQHL EFCEQLYETI DWNKLTFTSE DLKQNCISVI
IQTLLAFFAY STYHQELALQ HLLEHCAEHK LTETDFSALK SNVPDRGQPL RELIKPYADV
LLHNWISKQY SHSKFPYYLC FNTKEEYLNA HAGHILAYTL IYAKPEDVKR IDKSLSKESA
LPVLLAYVLS DLADCDESES VLFRQHHDNL TKNLAQLKLN PLDLPLNATT LYNAIKLVLD
KEQLAKLFGQ AVSCARMPMW YNLSVSSLFK CLKANIQGRS WSQDARIQWM SALMFEQPHV
LIDLLIILKS DCYNAVISSH VLRCFFLYAI LAVATLDAVS ALEASAKAEP DSLLLTVHAA
YFVRDAWYFS CRLLLATKCA QVQHAVLQLL QQLLSKGNFE AACLNAHMDD IAKILVQCVQ
QLHQPHLKQQ AIGLLETIVD NYAEQLHLDS LLAEASETAE WLALRQKLAT NSPNSFELDV
ASSIRVFLKS SRLQSLHTLR KYLAEHKHHL QDQEQLLLEL YNRLIRMVRE QEHSLEALKC
LAELGPLKIK HISYYFQTDF DAPTEQPMEQ FLGSIMQTLE QHLFQFNIHT QQSLINVAID
VVNSPSGRKL IAEHTNLRIF STKGSKASFL HASGSVRCID WLNLLRSCEH LDYESWLCTF
MSRIFIACGW QGFDAFAGKC FSFAKACLQP FIKLLLADKD VHLESLCAML DYFFAKSCDS
QASTGIYQEK RAIKRFLYMC ECVRFCNNWQ IPIKLSNVVR ASNHCQAYFL SIMYLELWAC
SASATELTNS SILADEEFQN CAKTAYESIG CLDAIPGFLN PLRSRLDYLS LNNNICGILV
ESDGLDMPNS QLCLDIMKSN GMLTFAKLQQ QQSQSKQLDY EILWRLGQWD EQVDGHQKVN
TANNMELEFK KHHYMALKSI SNREEENTLS AINNAYICVQ HILRDISVEC LQSVYKYMTW
LCTLQQATDF CQLQFGNHLS SDEINGTLDK WRTELELTYG NFNCKEHILT HQITLFKLAG
TRANRRLQQY YKQTPVDTYL LKCIAECKAA GKLNLASKYI AMLRTMPEVK APTKISVLLE
DAAVNARTGN YQTAKAILQH VVNHNEFQFC LQRVPALRLQ GEFLLDCNGE SMAHTLEHKF
MGSLKLLEQF RKHKTLLMEK HPDIFAWQSF DAFENEQRMA AHEAIAKYAD REYQQLHDYR
HSQEYEMLAH ITMHNLRLAG TVTDRQKAPE DRDRQVGAMH LKRFANLDEK ELQRIDDNLT
EHLCTALEHY MHYCQLDGGH SNAKIYRIIA LWFTNAENAQ MLLQLKSSLH TVPSYKFICA
VNQLAGRLGS KQDDFHKLLV ELLVRCAQEH PQQTFYKLYP LVYANMDGGH GNSQRADVAT
KLIAKACQGN AALAVISKQF EAMFPALINF ANSYLEMPPK GGRPNIKGIP DKLKKLNLLK
LTSVQCPTLE LAIQPSQQYN VNSIVRWKTS EFLVCGGLNA PIKLMCVCSD GLIRAQLIKG
KDDLRQDAVM QQVFGFVNEL LSSEPEFIER KLQLRTYKVT PLSMRSGILE WCTNTLPVAA
YLVGDGAGGA HLKYNPKDWT NRKCREMSLA VLRKPVAARQ EVYKEICKRV HPVFHYFLLE
KFAIPGVWFE RRLAYTNSVA TTSMVGYVLG IGDRHTQNIL IDEKTAEVVH IDFGHAFEQG
KVQATPETVP FRLTRDFVSA MGVCGTNGVF TKSCEATMHI LRRYKSVFAT ILEVLLYDPL
FIWGVLSSNQ ATTSNESKNL LAQRALLLVQ HKLEGRESGL LGNASVETQV QRLINEATLP
SNLALLYPGW DPYL
//