ID A0A0M4ET91_DROBS Unreviewed; 795 AA.
AC A0A0M4ET91;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 08-NOV-2023, entry version 31.
DE SubName: Full=Pms2 {ECO:0000313|EMBL:ALC40432.1};
GN ORFNames=Dbus_chr2Rg11 {ECO:0000313|EMBL:ALC40432.1};
OS Drosophila busckii (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC40432.1, ECO:0000313|Proteomes:UP000494163};
RN [1] {ECO:0000313|EMBL:ALC40432.1, ECO:0000313|Proteomes:UP000494163}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole larvae {ECO:0000313|EMBL:ALC40432.1};
RA Zhou Q., Bachtrog D.;
RT "Ancestral chromatin configuration constrains chromatin evolution on
RT differentiating sex chromosomes in Drosophila.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; CP012524; ALC40432.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M4ET91; -.
DR SMR; A0A0M4ET91; -.
DR STRING; 30019.A0A0M4ET91; -.
DR OMA; RCSKIRS; -.
DR Proteomes; UP000494163; Chromosome 2r sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Reference proteome {ECO:0000313|Proteomes:UP000494163}.
FT DOMAIN 229..386
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 699..795
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT COILED 634..698
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 795 AA; 88662 MW; CC3B3179A9DFFA4A CRC64;
MSDIKEEEAA IPKATDAASG NIKAIAKDTV HKICSGQAMA IKELVENSID AGATLVEINL
RDQGLQGLEV SDNGSGVEEA NLDGMTAKYH TSKIRDFVDL LGVETFGFRG EALSSLCALT
DMCIQTRHAS TDVALKVELD HDGKIKKRSP CARGVGTTVT LNNLFVTLPV RRRDFTRNIK
KEFNKMCQIL QAYCLVTKGV RIICSNQTPK GAKTVVMQTH GAQDVLANIT SVFGTRQAAD
LVPLKSPFEQ GALNEIGLRA ELESASDVAE ITCTQFNAED IEQLNQADFQ LEGYISSCRH
GAGRSSKDRQ YFFINARPCE PKNIAKVMND LYHRYNVQQQ PFIYLNVVTA RADVDVNLTP
DKRQLLLNNE KILLLALKKS LLNTFGALPS TFQMQNVSIV SMLEPKPKIK EETVNESAKE
DEIDVPISSS QGFMDVLSQW RRTGDTKGVA PPAPAKRPCE ETAEITARAM KMQKIQDFLT
QEAPKPRQLL SDEEDEELQD ALKLDKVKTS LDTSIVSLKQ LQQESAAYDE LMKPAKDTAQ
LERQESSLNT TYDELLKPAK ATRIDCKTQT PIKTLKISKV APAALEQQAQ TKQEFELSSS
QTTTEFSDDE IEMPTHIELD GDSDNEAAPA SVASGELRTS LAEIRQQLQA VEQQQQQRKQ
RAKLQRLRFK SEINPQQNQN AEAELEKEIG KADFARMQIV GQFNLGFIIV KLDDDLFIVD
QHAADEKFNF ETLQRTTQLE HQRLTRPQPL ELTAVNEMIL LDNLQVFEKN GFKFEIDETG
VNIIYIESPN IAHVL
//
