ID   A0A0M4EVX8_DROBS        Unreviewed;       968 AA.
AC   A0A0M4EVX8;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Botv {ECO:0000313|EMBL:ALC42125.1};
GN   ORFNames=Dbus_chr2Rg1704 {ECO:0000313|EMBL:ALC42125.1};
OS   Drosophila busckii (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC42125.1, ECO:0000313|Proteomes:UP000494163};
RN   [1] {ECO:0000313|EMBL:ALC42125.1, ECO:0000313|Proteomes:UP000494163}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Whole larvae {ECO:0000313|EMBL:ALC42125.1};
RA   Zhou Q., Bachtrog D.;
RT   "Ancestral chromatin configuration constrains chromatin evolution on
RT   differentiating sex chromosomes in Drosophila.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004648}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 47 family.
CC       {ECO:0000256|ARBA:ARBA00010271}.
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DR   EMBL; CP012524; ALC42125.1; -; Genomic_DNA.
DR   RefSeq; XP_017835795.1; XM_017980306.1.
DR   AlphaFoldDB; A0A0M4EVX8; -.
DR   STRING; 30019.A0A0M4EVX8; -.
DR   GeneID; 108595141; -.
DR   OMA; KFMGSHT; -.
DR   OrthoDB; 1220028at2759; -.
DR   Proteomes; UP000494163; Chromosome 2r sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:InterPro.
DR   GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:UniProt.
DR   InterPro; IPR040911; Exostosin_GT47.
DR   InterPro; IPR015338; GT64.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR39082:SF1; C4-TYPE ZINC RIBBON DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR39082; PHOSPHOLIPASE C-BETA-2-RELATED; 1.
DR   Pfam; PF03016; Exostosin; 1.
DR   Pfam; PF09258; Glyco_transf_64; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000494163};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        44..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          217..548
FT                   /note="Exostosin GT47"
FT                   /evidence="ECO:0000259|Pfam:PF03016"
FT   DOMAIN          711..953
FT                   /note="Glycosyl transferase 64"
FT                   /evidence="ECO:0000259|Pfam:PF09258"
FT   COILED          109..171
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   968 AA;  110900 MW;  B3DF7C9A7911698A CRC64;
     MSVAFDLDKP LDMDSGKEKQ VLITAGPNAR HNISISWMRR CRHYKLAIII LLLLVLLPLL
     AHRRLLSAEQ DAQPTDVHRS RPLLDAYEDF SAMRASDLKM RIEEMLRIKS TVSVELRELE
     SRRQKLQSDI SQYNQKIEEL KQELLREQTE LERLKISVEQ AQVAQQEAVQ RNTPELALPR
     TLLPSVLPRK MLAVGSDVSD ACEMHNCFDH SRCSLTSGFP VYLYDPDVHS VQRAGYDIDG
     FLKTTLKQTL GYNAHIVREP KQACIYLVLV GEALLEQDLL RNNRYAAQEA EHQQRATAAN
     DKQHKESPID MQKLYALPYW GGDGRNHVLL NLARRDLSST RNNPLLGQNT MRAIVVQSSF
     ERNQFRPGYD LIVPPILGPP GGDVWQECAS MLPARRKYLL SFQGELRPTG IVQTAAQPLD
     DFILEHLKDM SHGATQDQFQ LQFECVPAIE QHQELALVDW TLCGTESSRK QLLKDSTFAL
     ILPPLGARVS STLMLARLFE ALRSGAVPVI LGADELRLPY AETIDWRRVA VLLPKARITE
     LHFLLRAVQD ADLLLLRRQG RLIWERYLSS VQATVDTLIA SLRDRLGIPP RPVVNIIAQS
     VFNSSFIPLK SEPPVGMDTE PEESLGPIEP PYPSPAFRRN YTILRLQSKE AWNDWFDPFY
     LYPQLPFDPA LPSEAKFMGS HTGFRPIGKG IGGAGKEFSE ALGGNYPREQ FTIVMLTYER
     EQVLMDSLGR LYGLPYLHKV VVVWNSPKPP LDDLRWPDIG VPVSVVRAPR NSLNNRFLPF
     DVIETEAVLS VDDDAHLRHD EILFGFRVWR EHRDRVVGFP GRYHAWDLSS NNMWHYNSNY
     SCELSMVLTG AAFIHKYYMY LYTYHIPQAI RDKVDEYMNC EDIAMNFLVS HMTRKPPVKV
     TSRWTFRCPG CPVSLSEDDT HFQERHKCIN FFSQVFGYTP LLNTQYRADS ILFKTRIPHD
     KQKCFKYI
//