ID A0A0M4EW43_DROBS Unreviewed; 1019 AA.
AC A0A0M4EW43;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=CG10362 {ECO:0000313|EMBL:ALC49610.1};
GN ORFNames=Dbus_chrXg1466 {ECO:0000313|EMBL:ALC49610.1};
OS Drosophila busckii (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC49610.1, ECO:0000313|Proteomes:UP000494163};
RN [1] {ECO:0000313|EMBL:ALC49610.1, ECO:0000313|Proteomes:UP000494163}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole larvae {ECO:0000313|EMBL:ALC49610.1};
RA Zhou Q., Bachtrog D.;
RT "Ancestral chromatin configuration constrains chromatin evolution on
RT differentiating sex chromosomes in Drosophila.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP012528; ALC49610.1; -; Genomic_DNA.
DR RefSeq; XP_017852924.1; XM_017997435.1.
DR AlphaFoldDB; A0A0M4EW43; -.
DR STRING; 30019.A0A0M4EW43; -.
DR GeneID; 108606902; -.
DR OMA; RRTPYTH; -.
DR OrthoDB; 3681901at2759; -.
DR Proteomes; UP000494163; Chromosome x sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0044233; C:mitochondria-associated endoplasmic reticulum membrane; IEA:InterPro.
DR GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0051560; P:mitochondrial calcium ion homeostasis; IEA:InterPro.
DR GO; GO:1990456; P:mitochondrion-endoplasmic reticulum membrane tethering; IEA:InterPro.
DR CDD; cd20825; C1_PDZD8; 1.
DR CDD; cd21674; SMP_PDZD8; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR039275; PDZD8.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR031468; SMP_LBD.
DR PANTHER; PTHR21519; PDZ DOMAIN-CONTAINING PROTEIN 8; 1.
DR PANTHER; PTHR21519:SF1; PDZ DOMAIN-CONTAINING PROTEIN 8; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS51847; SMP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000494163};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00023055};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 7..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 82..273
FT /note="SMP-LTD"
FT /evidence="ECO:0000259|PROSITE:PS51847"
FT DOMAIN 340..410
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 716..766
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 468..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 850..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..517
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1019 AA; 112765 MW; CBE92C74A6E8162D CRC64;
MEIPISNILL LCLIFLLIGG VIMILLQYLI FIKFSNLPDE SEEQKQMNAK YTLPQNIKHT
ARHLKTQIEG NNCEHKDNHA QDSSALASLN FVMQFLFHEF KNSNRVRKWF YRKLSIELDE
LITKTTTGKL LDKLTIKELE LGDQFPDIKS MSVHNVQLDE AEQRIENLDL LLDINYIGNF
STSIDADMVL GKKGSIMLKV KQLSGMARLQ FTRRPYTHWS LSFLGDPELN LVIESKYQGR
QMQSNITNLI SNQIRKAVRR KHTLPNYKLR YKPFFHWTAD EEANDCDIQP NGRLTVRVAE
LSRLMHWPGV AEVYCSITLA PVPFIEAQQR DNRHVLITLD VLVHKAKNQQ IGIVFKQSSG
QAVKIESVLP NTPACKSNLQ SGDALVAIQG KPVSSIQQIA KVVKNLQSTV CSLRIERLIP
GIIRNDAILE DLEKYDDLCD MRQQQQQQRL ESEEQLTAEL SAKHLAVKAR GSNDSSLSGT
PTNSPKKSNI IAKAIKKTMS RESPDTQKDR ELREKPKVEE ASVALEEVNY FYQHSTIDCA
FKELIHMDDV CHFQLDANSR YLNVCVFGKC AGERVLLGYN NIQISQVLGE CSETSLNQCL
KQLALNPAAL INSKTHVLSN QSGFNPNLCF GDITFGFSWL GNPNATASDS SAAAKSSSSS
SSGKSQSPAR NQASAVGAQD ELSAGGDSNS LKSGTLSADS AISSGTRSSD ASVSKAHNFI
RTHFHRATQC DFCGKKIWLK DAMQCKDCAF CCHKKCIAKC QIATVCGPVD CISVGAISTQ
PGGNSVVVNK PEFTITQADY EEDFEGGREE SPMEPALDVH RASLTGMLAQ GIKRQASNLD
IPGIVSTLTG TGSSSPQLNS KSLPPSPQHT PCSRKVSISE EATALSNRSS SVNPFELVTP
QLAALGAECT TLSYEQVSLL TEPILRHARH EDLMNLAKSY SKQLYAESPP TERVHKINEL
LTNLKLALDA ETEGYSDAEE ATSQQHRMES KSEERVQALS IIMLYLCTGL QHAQGSVNA
//
