ID A0A0M4F1F3_DROBS Unreviewed; 642 AA.
AC A0A0M4F1F3;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Hr78 {ECO:0000313|EMBL:ALC45100.1};
GN ORFNames=Dbus_chr3Lg2266 {ECO:0000313|EMBL:ALC45100.1};
OS Drosophila busckii (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC45100.1, ECO:0000313|Proteomes:UP000494163};
RN [1] {ECO:0000313|EMBL:ALC45100.1, ECO:0000313|Proteomes:UP000494163}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole larvae {ECO:0000313|EMBL:ALC45100.1};
RA Zhou Q., Bachtrog D.;
RT "Ancestral chromatin configuration constrains chromatin evolution on
RT differentiating sex chromosomes in Drosophila.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000256|RuleBase:RU004334}.
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DR EMBL; CP012525; ALC45100.1; -; Genomic_DNA.
DR RefSeq; XP_017844113.1; XM_017988624.1.
DR AlphaFoldDB; A0A0M4F1F3; -.
DR SMR; A0A0M4F1F3; -.
DR STRING; 30019.A0A0M4F1F3; -.
DR GeneID; 108600831; -.
DR OMA; RNKEYHH; -.
DR OrthoDB; 5400963at2759; -.
DR Proteomes; UP000494163; Chromosome 3l sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24083; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24083:SF54; NUCLEAR HORMONE RECEPTOR HR78; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000494163};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 52..127
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 412..637
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 123..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 642 AA; 70173 MW; 4BAAED9F13A06FFC CRC64;
MMGTSSGFKT EGTSGSFKTE ESLSMSLNSN AAAVAAGNAA SSAAAAASLS SVELCLVCGD
RASGRHYGAI SCEGCKGFFK RSIRKQLGYQ CRGAMNCEVT KHHRNRCQFC RLQKCLASGM
RSDSVQHERK PIVDRQERKP IADRREASTS NCIAGSSSVG SNAAAASSSN SSSKSCYQQS
RVKQEQQQQQ QQQQQRQQHA TAAALFQHAA TPPMGSAAST PFGLSENIFP MSLNFAELTQ
TLMLASQQQQ QASNSSAPLC YSPELSKPEV EDDDDDSMDN SSSLCLQLLA NSASNNNSQH
LNFNAAAAAA AAAGSDPGSA LPTPATVGLI QSSLNKRIID RALQMLQPIQ QQLERNQSVS
SNATSLNIKP ECESDADDSG TEDVDADLVE HMELDFDYCN RSDFVANEAI FAQDLFVNEA
QCAFHVQPPT LVHSYLNMHY VCETGARIIF LTVHMLRKVP AFELLDTYTQ MKLLRGSWPA
LLAVALAQCR QLAVGTIIGQ LVQSVRQLAE LEKMEPQKIT KLAQITHTLH HFVQEMQSLE
LTDLEFGLLR LIVLFNPMQL QQQRRERSLR AYVKRVQLYA MATLRRQAGG EERANVLFAT
LLPLSGLESE LTEELFFANL VGQMQIDAMI PFILMMCNSN GL
//
