ID A0A0M4F5F0_DROBS Unreviewed; 422 AA.
AC A0A0M4F5F0;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Lipase {ECO:0000256|PIRNR:PIRNR000862};
GN ORFNames=Dbus_chr3Rg1507 {ECO:0000313|EMBL:ALC46757.1};
OS Drosophila busckii (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=30019 {ECO:0000313|EMBL:ALC46757.1, ECO:0000313|Proteomes:UP000494163};
RN [1] {ECO:0000313|EMBL:ALC46757.1, ECO:0000313|Proteomes:UP000494163}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole larvae {ECO:0000313|EMBL:ALC46757.1};
RA Zhou Q., Bachtrog D.;
RT "Ancestral chromatin configuration constrains chromatin evolution on
RT differentiating sex chromosomes in Drosophila.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|PIRNR:PIRNR000862}.
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DR EMBL; CP012526; ALC46757.1; -; Genomic_DNA.
DR RefSeq; XP_017844835.1; XM_017989346.1.
DR AlphaFoldDB; A0A0M4F5F0; -.
DR SMR; A0A0M4F5F0; -.
DR STRING; 30019.A0A0M4F5F0; -.
DR GeneID; 108601448; -.
DR OMA; GHRNTYS; -.
DR OrthoDB; 3259424at2759; -.
DR Proteomes; UP000494163; Chromosome 3r sequence.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR006693; AB_hydrolase_lipase.
DR InterPro; IPR025483; Lipase_euk.
DR PANTHER; PTHR11005:SF100; LIPASE-RELATED; 1.
DR PANTHER; PTHR11005; LYSOSOMAL ACID LIPASE-RELATED; 1.
DR Pfam; PF04083; Abhydro_lipase; 1.
DR PIRSF; PIRSF000862; Steryl_ester_lip; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PIRNR:PIRNR000862};
KW Lipid degradation {ECO:0000256|PIRNR:PIRNR000862};
KW Lipid metabolism {ECO:0000256|PIRNR:PIRNR000862};
KW Reference proteome {ECO:0000313|Proteomes:UP000494163};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..422
FT /note="Lipase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005794040"
FT DOMAIN 54..113
FT /note="Partial AB-hydrolase lipase"
FT /evidence="ECO:0000259|Pfam:PF04083"
FT ACT_SITE 191
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT ACT_SITE 363
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT ACT_SITE 393
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
SQ SEQUENCE 422 AA; 48680 MW; FC5D135BEFFD0CAE CRC64;
MQYKLILALI FLFGYVWSVQ TAAVDVAPVD IDFYKLYNDP DAHLAFRERR TTRDRMAAHG
YPAEHHHVVT EDGYILGIFR IPYSHKLKNQ DKKRPVVLIQ HGLFSCSDAW ILSGPNDALP
YLLADAGFDV WIGNARGTTY SRNHTTLSTQ HPYFWRFDWH EIGVYDMSAM IDYALKTNGQ
GQKSLHYVGH SQGTTVYFAL MSTVPEYNKK IKTANLFAPI AIMKNMRNKL VRKAAPYLGH
HNTYSLLFSS QEFIPHNSFI SIMFFNLCEP DLNFRIVCNN VVGRLYDANR VNMTAMPEGM
ATHPAGCSTN QILHYLQEQQ SGHFRQYDHG PAKNLLVYKS EQPPDYPVEK ITSELHMWYS
DNDIMAAVED VLALAKRLPN HKLYHMEDPD WDHGDFALNK DVRKYLNEPV IEIMLKYEEA
HN
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