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Database: UniProt
Entry: A0A0M4GQ34_9ACTO
LinkDB: A0A0M4GQ34_9ACTO
Original site: A0A0M4GQ34_9ACTO 
ID   A0A0M4GQ34_9ACTO        Unreviewed;       371 AA.
AC   A0A0M4GQ34;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   18-JUL-2018, entry version 17.
DE   RecName: Full=Alanine dehydrogenase {ECO:0000256|PIRNR:PIRNR000183};
DE            EC=1.4.1.1 {ECO:0000256|PIRNR:PIRNR000183};
GN   ORFNames=AM609_10440 {ECO:0000313|EMBL:ALC99784.1};
OS   Actinomyces sp. oral taxon 414.
OC   Bacteria; Actinobacteria; Actinomycetales; Actinomycetaceae;
OC   Actinomyces.
OX   NCBI_TaxID=712122 {ECO:0000313|EMBL:ALC99784.1};
RN   [1] {ECO:0000313|EMBL:ALC99784.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0588 {ECO:0000313|EMBL:ALC99784.1};
RA   Babu N.S., Beckwith C.J., Beseler K.G., Brison A., Carone J.V.,
RA   Caskin T.P., Diamond M., Durham M.E., Foxe J.M., Go M.,
RA   Henderson B.A., Jones I.B., McGettigan J.A., Micheletti S.J.,
RA   Nasrallah M.E., Ortiz D., Piller C.R., Privatt S.R., Schneider S.L.,
RA   Sharp S., Smith T.C., Stanton J.D., Ullery H.E., Wilson R.J.,
RA   Serrano M.G., Buck G., Lee V., Wang Y., Carvalho R., Voegtly L.,
RA   Shi R., Duckworth R., Johnson A., Loviza R., Walstead R., Shah Z.,
RA   Kiflezghi M., Wade K., Ball S.L., Bradley K.W., Asai D.J.,
RA   Bowman C.A., Russell D.A., Pope W.H., Jacobs-Sera D., Hendrix R.W.,
RA   Hatfull G.F.;
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: L-alanine + H(2)O + NAD(+) = pyruvate + NH(3)
CC       + NADH. {ECO:0000256|PIRNR:PIRNR000183}.
CC   -!- PATHWAY: Amino-acid degradation; L-alanine degradation via
CC       dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step
CC       1/1. {ECO:0000256|PIRNR:PIRNR000183}.
CC   -!- SIMILARITY: Belongs to the AlaDH/PNT family.
CC       {ECO:0000256|PIRNR:PIRNR000183}.
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DR   EMBL; CP012590; ALC99784.1; -; Genomic_DNA.
DR   RefSeq; WP_053587217.1; NZ_CP012590.1.
DR   EnsemblBacteria; ALC99784; ALC99784; AM609_10440.
DR   KEGG; acq:AM609_10440; -.
DR   PATRIC; fig|712122.3.peg.2362; -.
DR   KO; K00259; -.
DR   UniPathway; UPA00527; UER00585.
DR   GO; GO:0000286; F:alanine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0042853; P:L-alanine catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd05305; L-AlaDH; 1.
DR   InterPro; IPR008141; Ala_DH.
DR   InterPro; IPR008142; AlaDH/PNT_CS1.
DR   InterPro; IPR007886; AlaDH/PNT_N.
DR   InterPro; IPR007698; AlaDH/PNT_NAD(H)-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR42795; PTHR42795; 1.
DR   Pfam; PF01262; AlaDh_PNT_C; 1.
DR   Pfam; PF05222; AlaDh_PNT_N; 1.
DR   PIRSF; PIRSF000183; Alanine_dh; 1.
DR   SMART; SM01002; AlaDh_PNT_C; 1.
DR   SMART; SM01003; AlaDh_PNT_N; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR00518; alaDH; 1.
DR   PROSITE; PS00836; ALADH_PNT_1; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|PIRNR:PIRNR000183, ECO:0000256|PIRSR:PIRSR000183-3};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000183-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000183}.
FT   DOMAIN        4    137       AlaDh_PNT_N. {ECO:0000259|SMART:SM01003}.
FT   DOMAIN      149    297       AlaDh_PNT_C. {ECO:0000259|SMART:SM01002}.
FT   NP_BIND     178    179       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   NP_BIND     239    240       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   NP_BIND     267    270       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   NP_BIND     298    301       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   ACT_SITE     96     96       Proton donor/acceptor.
FT                                {ECO:0000256|PIRSR:PIRSR000183-1}.
FT   ACT_SITE    270    270       Proton donor/acceptor.
FT                                {ECO:0000256|PIRSR:PIRSR000183-1}.
FT   BINDING      15     15       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000183-2}.
FT   BINDING      75     75       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000183-2}.
FT   BINDING     134    134       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   BINDING     198    198       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   BINDING     203    203       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   BINDING     220    220       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   BINDING     279    279       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
SQ   SEQUENCE   371 AA;  38492 MW;  F24D6B950831B2BC CRC64;
     MRIGVPAEIK NNEFRVAITP SGVHALTRRG HEVTVQAGAG AGSGIDDGEY AAAGAAIGDD
     VEALWADSEM ILKVKEPVES EYRFLRPGLV LFTYLHLAAD RPLTEELLAR RVTSIAYETV
     ATDSGALPLL APMSEIAGRL AAQVGADCLL RPRGGDGVLL GGAAGVRRGD VVVLGGGTAG
     LAAARVSAGL GADVTVFDVD PARMRHIEEV TGGAIRTRLS TELDVARACA GADLVIGAVL
     VPGARTPRLV TREMVRAMRP GSVLVDIAID QGGCFEDSRP TTHSEPTFEV EGSIFYCVAN
     MPGAVPHTST YALTNATLTY VLALADDGWR GACRARAELG RGLSTHDGVL YTEGVGRALG
     LETADAAALL A
//
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