ID A0A0M4MTR8_9SPHN Unreviewed; 791 AA.
AC A0A0M4MTR8;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=AMC99_01452 {ECO:0000313|EMBL:ALE16745.1};
OS Altererythrobacter epoxidivorans.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Erythrobacteraceae; Altererythrobacter.
OX NCBI_TaxID=361183 {ECO:0000313|EMBL:ALE16745.1, ECO:0000313|Proteomes:UP000057938};
RN [1] {ECO:0000313|EMBL:ALE16745.1, ECO:0000313|Proteomes:UP000057938}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.7731 {ECO:0000313|EMBL:ALE16745.1,
RC ECO:0000313|Proteomes:UP000057938};
RA Li Z., Cheng H., Huo Y., Xu X.;
RT "Complete genome sequence of a benzo[a]pyrene-degrading bacterium
RT Altererythrobacter epoxidivorans CGMCC 1.7731T.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP012669; ALE16745.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M4MTR8; -.
DR STRING; 361183.AMC99_01452; -.
DR KEGG; aep:AMC99_01452; -.
DR PATRIC; fig|361183.4.peg.1423; -.
DR Proteomes; UP000057938; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000057938}.
FT DOMAIN 43..324
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 325..592
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 64..71
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 791 AA; 89668 MW; C139FAA40F86344B CRC64;
MGKRAHSALA AQPCVPYLFT RFPMSSDNPP QQRQNAQVPA YAARLNPPQR EAVLTTEGPV
LMLAGAGTGK TAALTARLAH LVATGRAYPS QILCVTFTNK AAREMRHRVA GHLGEAVEGM
PWLGTFHSIC AKMLRRHAEL VGLESNYTII DTDDQIRLLK QLINDNDLDE KRWPARQLAG
LIDGWKNRGL NPEDLDAVDN EAYANGRGQQ FYKLYQDRLK ALNACDFGDL LLHMLNIFRR
EHDVLERYQR QFRYILVDEY QDTNAVQYLW LRLLAQASKN ICVVGDDDQS IYSWRGAEVA
NILRFEKDFP GAKVVKLEQN YRSTPHILGA ASGLIRANSE RHEKTLWTEH DHGDKVRVIG
VWDAPEEARR VGEEIERLER EGASLDEVAI LVRAQYQTRE FEDRFIQIGI NYRIIGGFRF
YERAEIRDAL AYLRVIAQPQ DDLAFERIYN QPKRGLGAKT LEKMHQHARR TGLPLAAASL
QIADSDELPA RAANTIGGLM RQFLHWREQS EQVTPADLLR MVMTESGYDE MLQKERTAES
AGRLENLSEL ARAMEEYETL GDFLEHVSLV MDNDAADDEE TVTIMTMHAA KGLEFDHVFL
PGWEEGVFPS QRAIDEGGLA SLEEERRLAY VGITRARRRC TIFHAANRRI YGQWTSSIPS
RFIEELPPEH IDQETTMTGG ASLWRANWTE QEDPFAHVSQ SRPDRSGARG PGWQRALATG
YETKPVRVQE NRRSAASFAA KPRTDVAIGA RVFHEKFGYG TVTDQEGNKL EIDFEHSGTK
RVIDSFVKLA D
//
