ID A0A0M4N0K9_9ACTN Unreviewed; 266 AA.
AC A0A0M4N0K9;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=23S rRNA (Uridine(2479)-2'-O)-methyltransferase {ECO:0000313|EMBL:VHO01703.1};
DE SubName: Full=RNA methyltransferase {ECO:0000313|EMBL:ALE19486.1};
GN Name=aviRb {ECO:0000313|EMBL:VHO01703.1};
GN ORFNames=AL705_08090 {ECO:0000313|EMBL:ALE19486.1}, LC603019_01629
GN {ECO:0000313|EMBL:VHO01703.1};
OS Lawsonella clevelandensis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Lawsonellaceae;
OC Lawsonella.
OX NCBI_TaxID=1528099 {ECO:0000313|EMBL:ALE19486.1, ECO:0000313|Proteomes:UP000068137};
RN [1] {ECO:0000313|EMBL:ALE19486.1, ECO:0000313|Proteomes:UP000068137}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=X1698 {ECO:0000313|EMBL:ALE19486.1,
RC ECO:0000313|Proteomes:UP000068137};
RX PubMed=26659691;
RA Nicholson A.C., Bell M., Humrighouse B.W., McQuiston J.R.;
RT "Complete Genome Sequences for Two Strains of a Novel Fastidious, Partially
RT Acid-Fast, Gram-Positive Corynebacterineae Bacterium, Derived from Human
RT Clinical Samples.";
RL Genome Announc. 3:e01462-15(2015).
RN [2] {ECO:0000313|EMBL:ALE19486.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=X1698 {ECO:0000313|EMBL:ALE19486.1};
RX PubMed=27130323; DOI=10.1099/ijsem.0.001122;
RA Bell M.E., Bernard K.A., Harrington S.M., Patel N.B., Tucker T.A.,
RA Metcalfe M.G., McQuiston J.R.;
RT "Lawsonella clevelandensis gen. nov., sp. nov., a new member of the
RT suborder Corynebacterineae isolated from human abscesses.";
RL Int. J. Syst. Evol. Microbiol. 66:2929-2935(2016).
RN [3] {ECO:0000313|EMBL:VHO01703.1, ECO:0000313|Proteomes:UP000324288}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USB-603019 {ECO:0000313|EMBL:VHO01703.1};
RA Seth-Smith MB H., Seth-Smith H.;
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP012390; ALE19486.1; -; Genomic_DNA.
DR EMBL; LR584267; VHO01703.1; -; Genomic_DNA.
DR RefSeq; WP_053962574.1; NZ_LR584267.1.
DR AlphaFoldDB; A0A0M4N0K9; -.
DR STRING; 1528099.AL705_08090; -.
DR GeneID; 84895501; -.
DR KEGG; cbq:AL705_08090; -.
DR OrthoDB; 9794400at2; -.
DR Proteomes; UP000068137; Chromosome.
DR Proteomes; UP000324288; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd18095; SpoU-like_rRNA-MTase; 1.
DR Gene3D; 3.30.1330.30; -; 1.
DR Gene3D; 3.40.1280.10; -; 1.
DR InterPro; IPR029028; Alpha/beta_knot_MTases.
DR InterPro; IPR029064; Ribosomal_eL30-like_sf.
DR InterPro; IPR001537; SpoU_MeTrfase.
DR InterPro; IPR013123; SpoU_subst-bd.
DR InterPro; IPR029026; tRNA_m1G_MTases_N.
DR PANTHER; PTHR43191:SF16; RNA METHYLASE-RELATED; 1.
DR PANTHER; PTHR43191; RRNA METHYLTRANSFERASE 3; 1.
DR Pfam; PF00588; SpoU_methylase; 1.
DR Pfam; PF08032; SpoU_sub_bind; 1.
DR SMART; SM00967; SpoU_sub_bind; 1.
DR SUPFAM; SSF75217; alpha/beta knot; 1.
DR SUPFAM; SSF55315; L30e-like; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:ALE19486.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000068137};
KW Transferase {ECO:0000313|EMBL:ALE19486.1}.
FT DOMAIN 30..103
FT /note="RNA 2-O ribose methyltransferase substrate binding"
FT /evidence="ECO:0000259|SMART:SM00967"
SQ SEQUENCE 266 AA; 28420 MW; A97B2DED40D1466F CRC64;
MEIFTERTPR VVSAAKLHRP AQRRKTGQFL AEGWNAVSEA IRYGDVIDVY VTEDAAARFA
STVVSARDRR LHVHYISPKA DKLLTDTVTP PGIYAVCQST VTDLATALDQ QPHPQLVLVG
VDTNDPGNAG TMVRLADAFG ADLVVFAGHS VDPENTKCVR SSAGSIYHLP VCRESDTEAA
LTALQSCGIQ LLATTMDGEV RLDQAEQLLS RPTAWLMGSE AHGLDPAVAA QADHTVTIPI
RGRAESLNLA TAASICLYTS ATAQQA
//
