ID A0A0M4QH74_9MICC Unreviewed; 293 AA.
AC A0A0M4QH74;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:ALE93130.1};
DE EC=1.1.1.157 {ECO:0000313|EMBL:ALE93130.1};
GN ORFNames=AOC05_13705 {ECO:0000313|EMBL:ALE93130.1};
OS Arthrobacter alpinus.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Arthrobacter.
OX NCBI_TaxID=656366 {ECO:0000313|EMBL:ALE93130.1, ECO:0000313|Proteomes:UP000062833};
RN [1] {ECO:0000313|Proteomes:UP000062833}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R3.8 {ECO:0000313|Proteomes:UP000062833};
RA See-Too W.S., Chan K.G.;
RT "Complete genome of Arthrobacter alpinus strain R3.8.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
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DR EMBL; CP012677; ALE93130.1; -; Genomic_DNA.
DR RefSeq; WP_062007716.1; NZ_CP012677.1.
DR AlphaFoldDB; A0A0M4QH74; -.
DR KEGG; aaq:AOC05_13705; -.
DR PATRIC; fig|656366.3.peg.2956; -.
DR OrthoDB; 9771883at2; -.
DR Proteomes; UP000062833; Chromosome.
DR GO; GO:0008691; F:3-hydroxybutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR PIRSF; PIRSF000105; HCDH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ALE93130.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000062833}.
FT DOMAIN 11..194
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 197..292
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT SITE 151
FT /note="Important for catalytic activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR000105-1"
SQ SEQUENCE 293 AA; 30738 MW; 987906F32C2A3D04 CRC64;
MSKVTNLPAR VGVLGGGRMG AGIAHAFLMA GCEVLVVERD DDAAAGARER VGSSVAKSVE
RGLADGTAEG RTVSRGIIMQ RLSVSTDYAA FVPCELVVEA VPEIWDLKVS SLQGVEKHLS
EAAVLASNTS SLSMSGLAAE LARPSNFIGL HFFNPVPAST LIEVVIAKQT RPELVATAKG
WVEALGKTAV VVNDAPGFAS SRLGVAIALE AMRMVEEGVA SAEDIDAAMV LGYKHPTGPL
RTTDIVGLDV RLGIAEYLAE TLGERFAPPA ILREKVARGE LGRKSGKGFF DWQ
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