ID A0A0M4R6D1_9PSEU Unreviewed; 565 AA.
AC A0A0M4R6D1;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=AMP-dependent synthetase {ECO:0000313|EMBL:ALE83076.1};
GN ORFNames=XF36_07840 {ECO:0000313|EMBL:ALE83076.1};
OS Pseudonocardia sp. HH130629-09.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Pseudonocardia.
OX NCBI_TaxID=1641402 {ECO:0000313|EMBL:ALE83076.1, ECO:0000313|Proteomes:UP000062082};
RN [1] {ECO:0000313|EMBL:ALE83076.1, ECO:0000313|Proteomes:UP000062082}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HH130629-09 {ECO:0000313|EMBL:ALE83076.1,
RC ECO:0000313|Proteomes:UP000062082};
RX PubMed=26438860; DOI=10.1073/pnas.1515348112;
RA Sit C.S., Van Arnam E.B., Ramadhar T.R.;
RT "Variable genetic architectures produce virtually identical molecules in
RT bacterial symbionts of fungus-growing ants.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:13150-13154(2015).
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; CP011868; ALE83076.1; -; Genomic_DNA.
DR RefSeq; WP_060711471.1; NZ_CP011868.1.
DR AlphaFoldDB; A0A0M4R6D1; -.
DR KEGG; pseh:XF36_07840; -.
DR PATRIC; fig|1641402.3.peg.1675; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000062082; Chromosome.
DR GO; GO:0016878; F:acid-thiol ligase activity; IEA:UniProt.
DR GO; GO:0016405; F:CoA-ligase activity; IEA:UniProt.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43605:SF10; ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3; 1.
DR PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Reference proteome {ECO:0000313|Proteomes:UP000062082}.
FT DOMAIN 66..398
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 461..538
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 565 AA; 61761 MW; 40A6E4389FFE1130 CRC64;
MATASPATET FLAARDFLLT HREDYDTAYR DFRWPELDEF NFALDHFDVV AADPERGARK
ALWIVEQDGS QAHWTWAELS ERSNRVANWL REQGVVRGDR VVLMLGNQLE LWETLLAAMK
LGAVVIPATT LLTPADLQDR VDRGRAAHVV VGADDAGKFD DVDGDYTRIA VRGAVAGWRD
YSGEAYSAAA EFTPDGVTKA SDTLLLYFTS GTTAKPKLVE HTHTSYPVGH LSTMYWIGLE
PGDVHLNISS PGWAKHAWSN VFAPWIAEAT VLVMNYARFD AESVLSVLDS CGVTSFCAPP
TVWRMLIQAD LSGLTTPPSK VVGAGEPLNP EVIEQVEKAW GLRIRDGFGQ TESSVQIGNP
PGQPVKPGSM GRPIPGFVVA LVDPATGKAA DEGEICLDLA HRPTGLMVGY ADDPERNAEA
MAGGYYHTGD VGSRDESGYI TYVGRADDVF KASDYRISPF ELESVLIEHP AVAEAAVVPS
PDPVRLAVPK AYVVLANGHE PTEETAKAIL RFAYDNLAPY KRIRRLEFFE LPKTISGKIR
RVELRGREGE IHADPAATPP TEYTL
//
