ID A0A0M4R707_9PSEU Unreviewed; 330 AA.
AC A0A0M4R707;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:ALE83413.1};
DE EC=1.1.1.157 {ECO:0000313|EMBL:ALE83413.1};
GN ORFNames=XF36_09860 {ECO:0000313|EMBL:ALE83413.1};
OS Pseudonocardia sp. HH130629-09.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Pseudonocardia.
OX NCBI_TaxID=1641402 {ECO:0000313|EMBL:ALE83413.1, ECO:0000313|Proteomes:UP000062082};
RN [1] {ECO:0000313|EMBL:ALE83413.1, ECO:0000313|Proteomes:UP000062082}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HH130629-09 {ECO:0000313|EMBL:ALE83413.1,
RC ECO:0000313|Proteomes:UP000062082};
RX PubMed=26438860; DOI=10.1073/pnas.1515348112;
RA Sit C.S., Van Arnam E.B., Ramadhar T.R.;
RT "Variable genetic architectures produce virtually identical molecules in
RT bacterial symbionts of fungus-growing ants.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:13150-13154(2015).
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DR EMBL; CP011868; ALE83413.1; -; Genomic_DNA.
DR RefSeq; WP_060714556.1; NZ_CP011868.1.
DR AlphaFoldDB; A0A0M4R707; -.
DR KEGG; pseh:XF36_09860; -.
DR PATRIC; fig|1641402.3.peg.2105; -.
DR OrthoDB; 9771883at2; -.
DR Proteomes; UP000062082; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008691; F:3-hydroxybutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF1; LAMBDA-CRYSTALLIN HOMOLOG; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000313|EMBL:ALE83413.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000062082};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..188
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 194..265
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 330 AA; 35131 MW; F1180F8CC30539C2 CRC64;
MPDLRPVSAI RTVACIGAGV IGAGWAAYFL ARGLRVRAWD PAPDAEETLR RVVDAAWPAL
TELGLAEGAD RDALTMFPTA AEAVAGADFV QESAPEDLTL KRSLLAELAD AAVAAGPDVV
VASSTSGFPM TDMATTAAHP DRVVVGHPFN PPYLIPLVEV VGGERTAAWT ASRAADFYRH
IGKSVIEMER ELPGFIANRL QEAIWREALH MVAAGEATPE EIDRSITDGP GLRWPVHGPC
LTFHLAGGRG GMAHMLDHFG PSLKAPWTRL EAPELTRELR DDMVAGAEVS AGGRPMAELV
AERDRAVIAV RRAVAVARQT TVQTTGETAR
//
